Expression of HuR is associated with increased cyclooxygenase-2 expression in uterine cervical carcinoma

International Journal of Gynecological Pathology

Volumn 26, Issue 3, 2007, Pages 229-234

  Lim, Sung Jig ^a   Kim, Hyun Jung ^a   Kim, Jung Yeon ^a   Park, Kyeougmee ^a   Lee, Chul Min ^a  

^a Inje University College of Medicine   (South Korea)

Author keywords

Cyclooxygenase 2; HuR; Uterine cervix

Indexed keywords

CYCLOOXYGENASE 2; HU ANTIGEN; HU ANTIGEN R; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER INVASION; CANCER SURVIVAL; CARCINOMA IN SITU; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; CYTOPLASM; DISEASE SEVERITY; ENZYME RELEASE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVASIVE CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; TUMOR VOLUME; UPREGULATION; UTERINE CERVIX CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, SURFACE; CARCINOMA, SQUAMOUS CELL; CELL NUCLEUS; CYCLOOXYGENASE 2; CYTOPLASM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM STAGING; NEOVASCULARIZATION, PATHOLOGIC; RNA-BINDING PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 34250889456     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pgp.0000236946.82334.07     Document Type: Article

References (29)

1. Chen CY, Shyu AB. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci 1995;20:465-70.
2. Sachs AB. Messenger RNA degradation in eukaryotes. Cell 1993;74:413-21.
3. Ma WJ, Cheng S, Campbell C, et al. Cloning and characterization of HuR, a ubiquitously expressed ELAV-like protein. J Biol Chem 1996;271:8144-51.
4. Atasoy U, Watson J, Patel D, et al. ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. J Cell Sci 1998;111:3145-56.
5. Fan XC, Steitz JA. Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increased in the in vivo stability of ARE-containing mRNAs. EMBO J 1998;17:3448-60.
6. Peng SS, Chen CY, Xu N, et al. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J 1998;17:3461-70.
7. Gallouzi IE, Steitz JA. Delineation of mRNA export pathways by the use of cell-permeable peptides. Science 2001;294:1895-901.
8. Sheng H, Shao J, Dixon DA, et al. Transforming growth factor β1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem 2000;275:6628-35.
9. Dixon DA, Kaplan CD, McIntyre TM, et al. Post-transcriptional control of cyclooxygenase-2 gene expression. The role of the 3-untranslated region. J Biol Chem 2000;275:11750-7.
10. Lasa M, Mahtani KR, Finch A, et al. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol 2000;20:4265-74.
11. Ristimaki A, Garfinkel S, Wessendorf J, et al. Induction of cyclooxygenase-2 by interleukin-1α. J Biol Chem 1994;269:11769-75.
12. Narko K, Hla T. Down-regulation of cytokine-induced cyclooxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation. Biochem J 1996;318:325-31.
13. Dixon DA, Tolley ND, King PH, et al. Altered expression of the mRNA stability factor HuR promotes cyclooxygease-2 expression in colon cancer cells. J Clin Invest 2001;108:1657-65.
14. Sengupta S, Jang BC, Wu MT, et al. The RNA-binding protein HuR regulates the expression of cyclooxygease-2. J Biol Chem 2003;278:25227-33.
15. Denkert C, Weichert W, Winzer KJ, et al. Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Clin Cancer Res 2004;10:5580-6.
16. Mrena M, Wiksten JP, Thiel A, et al. Cyclooxygenase-2 is an independent prognostic factor in gastric cancer and its expression is regulated by the messenger RNA stability factor HuR. Clin Cancer Res 2005;11:7362-8.
17. Denkert C, Weichert W, Pest S, et al. Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. Cancer Res 2004;64:189-95.
18. Nabors LB, Gillespie GY, Harkins L, et al. HuR, a RNA stability factor, is expressed in malignant brain tumors and binds to adenine- and uridine-rich elements within 3 untranslated regions of cytokine and angiogenic factor mRNAs. Cancer Res 2001;61:2154-61.
19. Cho NH, Kang S, Hong S, et al. Elevation of cyclin B1, active cdc2, and Hur in cervical neoplasia with human papillomavirus type 18 infection. Cancer Lett 2006;232:170-8.
20. Cannistra SA, Niloff JM. Cancer of the uterine cervix. N Engl J Med 1996;34:1030-8.
21. Devesa SS, Young JL, Brinton LA, et al. Recent trends in cervix uteri cancer. Cancer 1989;64:2184-90.
22. Kim JY, Lim SJ, Park K, et al. Cyclooxygenase-2 and c-erbB-2 expression in uterine cervical neoplasm assessed using tissue microarrays. Gynecol Oncol 2005;97:337-41.
23. Ford LP, Watson J, Keene JD, et al. ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes Dev 1999;13:188-201.
24. Wang W, Caldwell MC, Lin S, et al. HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation. EMBO J 2000;19:2340-50.
25. Wein G, Rössler M, Klug R, et al. The 3-UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU-rich element interacting with the mRNA stabilizing factors HuD and HuR. Eur J Biochem 2003;270:350-65.
26. Tran H, Maurer F, Nagamine Y. Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. Mol Cell Biol 2003;23:7177-88.
27. Wang W, Yang X, Kawai T, et al. AMPK-regulated phosphorylation and acetylation of importin α1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem 2004;279:48376-88.
28. Yang X, Wang W, Fan J, et al. Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR. J Biol Chem 2004;279:49298-306.
29. Subbbaramaiah K, Marmo TP, Dixon DA, et al. Regulation of cyclooxygenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuR. J Biol Chem 2003;278:37637-47.