Endothelin contributes to blunted renal autoregulation observed with a high-salt diet

American Journal of Physiology - Renal Physiology

Volumn 309, Issue 8, 2015, Pages F687-F696

  Fellner, Robert C ^a   Guan, Zhengrong ^a,b   Cook, Anthony K ^a,b   Pollock, David M ^a,b   Inscho, Edward W ^a,b  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

Afferent arterioles; BQ 123; BQ 788; ETA receptors; ETB receptors

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; CYCLO(TRP-ASP-PRO-VAL-LEU); CYCLOPEPTIDE; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST; OLIGOPEPTIDE; PIPERIDINE DERIVATIVE; SODIUM INTAKE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTERIOLE; ARTICLE; BODY WEIGHT; CARDIOVASCULAR AUTOREGULATION; CAROTID ARTERY; CONTROLLED STUDY; FOOD INTAKE; GLOMERULUS CAPILLARY; HIGH SODIUM INTAKE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY BLOOD FLOW; KIDNEY CIRCULATION; KIDNEY FUNCTION; KIDNEY PERFUSION; MALE; MICROCIRCULATION; NONHUMAN; OXIDATIVE STRESS; PERFUSION PRESSURE; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; ADVERSE EFFECTS; ANIMAL; DIET; DRUG EFFECTS; HOMEOSTASIS; METABOLISM; NEPHRON; SODIUM INTAKE; SPRAGUE DAWLEY RAT;

ANIMALS; ARTERIOLES; DIET; ENDOTHELIN A RECEPTOR ANTAGONISTS; ENDOTHELIN B RECEPTOR ANTAGONISTS; ENDOTHELINS; HOMEOSTASIS; MALE; MICROCIRCULATION; NEPHRONS; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RENAL CIRCULATION; SODIUM, DIETARY;

EID: 84944446031     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00641.2014     Document Type: Article

References (62)

1. Abu-Amarah I, Bidani AK, Hacioglu R, Williamson GA, Griffin KA. Differential effects of salt on renal hemodynamics and potential pressure transmission in stroke-prone and stroke-resistant spontaneously hypertensive rats. Am J Physiol Renal Physiol 289: F305–F313, 2005.
2. Appel LJ, Frohlich ED, Hall JE, Pearson TA, Sacco RL, Seals DR, Sacks FM, Smith SC, Vafiadis DK, Van Horn LV. The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association. Circulation 123: 1138–1143, 2011.
3. Arendshorst WJ. Autoregulation of renal blood flow in spontaneously hypertensive rats. Circ Res 44: 344–349, 1979.
4. Bidani AK, Griffin KA, Williamson G, Wang X, Loutzenhiser R. Protective importance of the myogenic response in the renal circulation. Hypertension 54: 393–398, 2009.
5. Bigazzi R, Bianchi S, Baldari D, Sgherri G, Baldari G, Campese VM. Microalbuminuria in salt-sensitive patients. A marker for renal and cardiovascular risk factors. Hypertension 23: 195–199, 1994.
6. Boesen EI, Pollock DM. Acute increases of renal medullary osmolality stimulate endothelin release from the kidney. Am J Physiol Renal Physiol 292: F185–F191, 2007.
7. Casellas D, Carmines PK, Navar LG. Microvascular reactivity of in vitro blood perfused juxtamedullary nephrons from rats. Kidney Int 28: 752–759, 1985.
8. Casellas D, Navar LG. In vitro perfusion of juxtamedullary nephrons in rats. Am J Physiol Renal Fluid Electrolyte Physiol 246: F349–F358, 1984.
9. Chevalier RL, Kaiser DL. Autoregulation of renal blood flow in the rat: effects of growth and uninephrectomy. Am J Physiol Renal Fluid Electrolyte Physiol 244: F483–F487, 1983.
10. Cohen HJ, Marsh DJ, Kayser B. Autoregulation in vasa recta of the rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 245: F32–F40, 1983.
11. Conger JD, Burke TJ. Effects of anesthetic agents on autoregulation of renal hemodynamics in the rat and dog. Am J Physiol 230: 652–657, 1976.
12. Cordaillat M, Reboul C, Gaillard V, Lartaud I, Jover B, Rugale C. Plasma volume and arterial stiffness in the cardiac alterations associated with long-term high sodium feeding in rats. Am J Hypertens 24: 451–457, 2011.
13. Cupples WA, Braam B. Assessment of renal autoregulation. Am J Physiol Renal Physiol 292: F1105–F1123, 2007.
14. Endlich K, Hoffend J, Steinhausen M. Localization of endothelin ETA and ETB receptor-mediated constriction in the renal microcirculation of rats. J Physiol 497: 211–218, 1996.
15. Fellner RC, Cook AK, O’Connor PM, Zhang S, Pollock DM, Inscho EW. High salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism. Am J Physiol Renal Physiol 307: F33–F40, 2014.
16. Fellner SK, Arendshorst W. Endothelin-A and -B receptors, superoxide, and Ca2+ signaling in afferent arterioles. Am J Physiol Renal Physiol 292: F175–F184, 2007.
17. Gariepy CE, Williams SC, Richardson JA, Hammer RE, Yanagisawa M. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. J Clin Invest 102: 1092–1101, 1998.
18. Gregan B, Schaefer M, Rosenthal W, Oksche A. Fluorescence resonance energy transfer analysis reveals the existence of endothelin-A and endothelin-B receptor homodimers. J Cardiovasc Pharmacol 44, Suppl 1: S30–S33, 2004.
19. Guan Z, Giddens MI, Osmond DA, Cook AK, Hobbs JL, Zhang S, Yamamoto T, Pollock JS, Pollock DM, Inscho EW. Immunosuppression preserves renal autoregulatory function and microvascular P2X1 receptor reactivity in Ang II hypertensive rats. Am J Physiol Renal Physiol 304: F801–F807, 2013.
20. Guan Z, Inscho EW. Endothelin and the renal vasculature. Contrib Nephrol 172: 35–49, 2011.
21. Harada N, Himeno A, Shigematsu K, Sumikawa K, Niwa M. Endothelin- 1 binding to endothelin receptors in the rat pituitary gland: possible formation of an ETA-ETB receptor heterodimer. Cell Mol Neurobiol 2: 207–226, 2002.
22. Harrison-Bernard LM, De Garavilla L, Bivona BJ. Enhanced vascular chymase-dependent conversion of endothelin in the diabetic kidney. Ochsner J 13: 49–55, 2013.
23. Hasselblatt M, Kamrowski-Kruck H, Jensen N, Schilling L, Kratzin H, Sirén AL, Ehrenreich H. ETA and ETB receptor antagonists synergistically increase extracellular endothelin-1 levels in primary rat astrocyte cultures. Brain Res 785: 253–261, 1998.
24. He FJ, Markandu ND, MacGregor GA. Modest salt reduction lowers blood pressure in isolated systolic hypertension and combined hypertension. Hypertension 46: 66–70, 2005.
25. Hickey KA, Rubanyi G, Paul RJ, Highsmith RF. Characterization of a coronary vasoconstrictor produced by cultured endothelial cells. Am J Physiol Cell Physiol 248: C550–C556, 1985.
26. Ibarrola AM, Inscho EW, Vari RC, Navar LG. Influence of adenosine receptor blockade on renal function and autoregulation. J Am Soc Nephrol 2: 991–999, 1991.
27. Imig JD, Pham BT, LeBlanc EA, Reddy KM, Falck JR, Inscho EW. Cytochrome P450 and cyclooxygenase metabolites contribute to the endothelin-1 afferent arteriolar vasoconstrictor and calcium responses. Hypertension 35: 307–312, 2000.
28. Inscho EW. Mysteries of renal autoregulation. Hypertension 53: 299–306, 2009.
29. Inscho EW, Imig JD, Cook AK, Pollock DM. ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelin. Br J Pharmacol 146: 1019–1026, 2005.
30. Iversen BM, Heyeraas KJ, Sekse I, Andersen KJ, Ofstad J. Autoregulation of renal blood flow in two-kidney, one-clip hypertensive rats. Am J Physiol Renal Fluid Electrolyte Physiol 251: F245–F250, 1986.
31. Just A. Mechanisms of renal blood flow autoregulation: dynamics and contributions. Am J Physiol Regul Integr Comp Physiol 292: R1–R17, 2007.
32. Just A, Olson AJM, Arendshorst WJ. Dual constrictor and dilator actions of ETB receptors in the rat renal microcirculation: interactions with ETA receptors. Am J Physiol Renal Physiol 286: F660–F668, 2004.
33. Kallskog O, Lindbom LO, Ulfendahl HR, Wolgast M. The pressureflow relationship of different nephron populations in the rat. Acta Physiol Scand 94: 309–312, 1975.
34. Kittikulsuth W, Pollock JS, Pollock DM. Sex differences in renal medullary endothelin receptor function in angiotensin II hypertensive rats. Hypertension 58: 212–218, 2011.
35. Kohan DE, Inscho EW, Wesson D, Pollock DM. Physiology of endothelin and the kidney. Comp Physiol 1: 883–919, 2011.
36. Kohan DE, Rossi NF, Inscho EW, Pollock DM. Regulation of blood pressure and salt homeostasis by endothelin. Physiol Rev 91: 1–77, 2011.
37. Kon V, Badr KF. Biological actions and pathophysiological significance of endothelin in the kidney. Kidney Int 40: 1–12, 1991.
38. Lanese DM, Yuan BH, McMurtry IF, Conger JD. Comparative sensitivities of isolated rat renal arterioles to endothelin. Am J Physiol Renal Fluid Electrolyte Physiol 263: F894–F899, 1992.
39. Liu Z, Peng J, Lu F, Zhao Y, Wang S, Sun S, Zhang H, Diao Y. Salt loading and potassium supplementation: effects on ambulatory arterial stiffness index and endothelin-1 levels in normotensive and mild hypertensive patients. J Clin Hypertens 15: 485–496, 2013.
40. Loutzenhiser R, Griffin K, Williamson G, Bidani A. Renal autoregulation: new perspectives regarding the protective and regulatory roles of the underlying mechanisms. Am J Physiol Regul Integr Comp Physiol 290: R1153–R1167, 2006.
41. Masaki T, Miwa S, Sawamura T, Ninomiya H, Okamoto Y. Subcellular mechanisms of endothelin action in vascular system. Eur J Pharmacol 375: 133–138, 1999.
42. Masaki T, Ninomiya H, Sakamoto A, Okamoto Y. Structural basis of the function of endothelin receptor. Mol Cell Biochem 190: 153–156, 1999.
43. Moore LC. Interaction of tubuloglomerular feedback and proximal nephron reabsorption in autoregulation. Kidney Int 22, Suppl 12: S173–S178, 1982.
44. Nakano D, Pollock DM. New concepts in endothelin control of sodium balance. Clin Exp Pharmacol Physiol 39: 104–110, 2012.
45. Navar LG, Inscho EW, Majid DSA, Imig JD, Harrison-Bernard LM, Mitchell KD. Paracrine regulation of the renal microcirculation. Physiol Rev 76: 425–536, 1996.
46. Nurkiewicz TR, Boegehold MA. High dietary salt alters arteriolar myogenic responsiveness in normotensive and hypertensive rats. Am J Physiol Heart Circ Physiol 275: H2095–H2104, 1998.
47. Nurkiewicz TR, Boegehold MA. Limitation of arteriolar myogenic activity by local nitric oxide: segment-specific effect of dietary salt. Am J Physiol Heart Circ Physiol 277: H1946–H1955, 1999.
48. Nurkiewicz TR, Boegehold MA. High salt intake reduces endotheliumdependent dilation of mouse arterioles via superoxide anion generated from nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 292: R1550–R1556, 2007.
49. Osmond DA, Inscho EW. P2X1 receptor blockade inhibits whole kidney autoregulation of renal blood flow in vivo. Am J Physiol Renal Physiol 298: F1360–F1368, 2010.
50. Osmond DA, Zhang S, Pollock JS, Yamamoto T, De Miguel C, Inscho EW. Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension. Am J Physiol Renal Physiol 306: F619–F628, 2014.
51. Pimenta E, Gafddam KK, Oparil S, Aban I, Husain S, Dell’Italia LJ, Calhoun DA. Effects of dietary sodium reduction on blood pressure in subjects with resistant hypertension. Results from a randomized trial. Hypertension 54: 475–481, 2009.
52. Ploth DW, Roy RN, Huang WC, Navar LG. Impaired renal blood flow and cortical pressure autoregulation in the contralateral kidney of Goldblatt hypertensive rats. Hypertension 3: 67–74, 1981.
53. Rothermund L, Luckert S, Kossmehl P, Paul M, Kreutz R. Renal endothelin ETA/ETB receptor imbalance differentiates salt-sensitive from salt-resistant spontaneous hypertension. Hypertension 37: 275–280, 2001.
54. Saeed A, DiBona GF, Guron G. Effects of endothelin receptor antagonists on renal hemodynamics in angiotensin II-infused rats on high NaCl intake. Kidney Blood Press Res 36: 258–267, 2012.
55. Saeed A, DiBona GF, Marcussen N, Guron G. High-NaCl intake impairs dynamic autoregulation of renal blood flow in ANG II-infused rats. Am J Physiol Regul Integr Comp Physiol 299: R1142–R1149, 2010.
56. Schneider MP, Inscho EW, Pollock DM. Attenuated vasoconstrictor responses to endothelin in afferent arterioles during a high-salt diet. Am J Physiol Renal Physiol 292: F1208–F1214, 2007.
57. Schnermann J, Briggs J, Wright FS. Feedback-mediated reduction of glomerular filtration rate during infusion of hypertonic saline. Kidney Int 20: 462–468, 1981.
58. Shi Y, Lau C, Cupples WA. Interactive modulation of renal myogenic autoregulation by nitric oxide and endothelin acting through ET-B receptors. Am J Physiol Regul Integr Comp Physiol 292: R354–R361, 2007.
59. Speed JS, Pollock DM. Endothelin, kidney disease, and hypertension. Hypertension 61: 1142–1145, 2013.
60. Tsai YH, Ohkita M, Gariepy CE. Chronic high-sodium diet increases aortic wall endothelin-1 expression in a blood pressure-independent fashion in rats. Exp Biol Med 231: 813–817, 2006.
61. Walker M III, Harrison-Bernard LM, Cook AK, Navar LG. Dynamic interaction between myogenic and TGF mechanisms in afferent arteriolar blood flow autoregulation. Am J Physiol Renal Physiol 279: F858–F865, 2000.
62. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel and potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411–415, 1988.