Renal endothelin ETA/ETB receptor imbalance differentiates salt-sensitive from salt-resistant spontaneous hypertension

Hypertension

Volumn 37, Issue 2 I, 2001, Pages 275-280

  Rothermund, Lars ^a,b   Luckert, Susanne ^a   Komehl, Peter ^a   Paul, Martin ^a   Kreutz, Reinhold ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Endothelin; Hypertension, sodium dependent; Rats, spontaneously hypertensive; Rats, stroke prone SHR; Receptors, endothelin; Sodium

Indexed keywords

ALBUMIN; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; MESSENGER RNA; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ESSENTIAL HYPERTENSION; GENE EXPRESSION; GLOMERULOSCLEROSIS; INTERSTITIAL NEPHRITIS; KIDNEY; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SALT LOADING; SYSTOLIC BLOOD PRESSURE; TARGET ORGAN; URINARY EXCRETION;

EID: 0035098045     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.37.2.275     Document Type: Article

References (19)

1. Endothelin: Role in hypertension
2. Endothelin antagonists in renal disease
3. Increased expression bi endothelin-I gene in blood vessels of deoxycorticosterone acetate-salt hypertensive rats
4. ET(A) receptor blockade prevents increased tissue endothelin-I, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension
5. A -receptor antagonism attenuates the hypertensive response to salt and target organ damage in the Sabra experimental model of salt-sensitive genetic hypertension
6. Nephroprotection of an ET(A)-receptor blocker (LU 135252) in salt-loaded uninephrectomized stroke-prone spontaneously hypertensive rats
7. Endothelin system-dependent cardiac remodeling in renovascular hypertension
8. The cardiac endothelin system in established pressure overload left ventricular hypertrophy
9. Mesangial immune injury, hypertension, and progressive glomerular damage in Dahl rats
10. Calcium blockade versus ACE inhibition in clipped and unclipped kidneys of 2K-IC rats
11. Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension: Mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and glomerulosclerosis
12. Increased renal endothelin production in rats with reduced renal mass
13. Renal endothelin gene expression is increased in remnant kidney and correlates with disease progression
14. Upregulation of endothelin B receptors in kidneys of DOCA-salt hypertensive rats
15. Enhanced blood pressure sensitivity to DOCA-salt treatment in endothelin ET(B) receptor-deficient rats
16. Salt-sensitive hypertension in endorhelin-B receptor-deficient rats
17. Salt-sensitive hypertension in endothelin-B-receptor-deficient mice due to impaired renal salt excretion
18. + channels by endothelin-1 in distal nephron cells
19. Endothelins in the normal and diseased kidney