Reprogrammed functional brown adipocytes ameliorate insulin resistance and dyslipidemia in diet-induced obesity and type 2 diabetes

Stem Cell Reports

Volumn 5, Issue 4, 2015, Pages 569-581

  Kishida, Tsunao ^a   Ejima, Akika ^a   Yamamoto, Kenta ^a   Tanaka, Seiji ^a   Yamamoto, Toshiro ^a   Mazda, Osam ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; KRUPPEL LIKE FACTOR 4; LEPTIN RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHOLIPID; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 1; DNA BINDING PROTEIN; PRDM16 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL METABOLIC RATE; BROWN ADIPOCYTE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET INDUCED OBESITY; DYSLIPIDEMIA; FIBROBLAST; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE URINE LEVEL; HUMAN; HUMAN CELL; IN VIVO STUDY; INSULIN RESISTANCE; LIPID DIET; LIPID STORAGE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NUCLEAR REPROGRAMMING; ONCOGENE C MYC; ONCOGENE MYC; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; THERMOGENESIS; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; ADVERSE EFFECTS; ANIMAL; C57BL MOUSE; CELL LINE; CYTOLOGY; DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; GENETIC TRANSDUCTION; GENETICS; INDUCED PLURIPOTENT STEM CELL; MALE; METABOLISM; OBESITY; TRANSPLANTATION;

ADIPOCYTES, BROWN; ANIMALS; CELL LINE; CELLULAR REPROGRAMMING; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; DNA-BINDING PROTEINS; DYSLIPIDEMIAS; FIBROBLASTS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; OBESITY; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC;

EID: 84944441201     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2015.08.007     Document Type: Article

References (44)

1. T. Ahfeldt, R.T. Schinzel, Y.K. Lee, D. Hendrickson, A. Kaplan, D.H. Lum, R. Camahort, F. Xia, J. Shay, E.P. Rhee, and et al. Programming human pluripotent stem cells into white and brown adipocytes Nat. Cell Biol. 14 2012 209 219
2. M. Caiazzo, M.T. Dell'Anno, E. Dvoretskova, D. Lazarevic, S. Taverna, D. Leo, T.D. Sotnikova, A. Menegon, P. Roncaglia, G. Colciago, and et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts Nature 476 2011 224 227
3. K. Chechi, A.C. Carpentier, and D. Richard Understanding the brown adipocyte as a contributor to energy homeostasis Trends Endocrinol. Metab. 24 2013 408 420
4. A.M. Cypess, S. Lehman, G. Williams, I. Tal, D. Rodman, A.B. Goldfine, F.C. Kuo, E.L. Palmer, Y.H. Tseng, A. Doria, and et al. Identification and importance of brown adipose tissue in adult humans N. Engl. J. Med. 360 2009 1509 1517
5. S. Gesta, Y.H. Tseng, and C.R. Kahn Developmental origin of fat: tracking obesity to its source Cell 131 2007 242 256
6. M. Giralt, and F. Villarroya White, brown, beige/brite: different adipose cells for different functions? Endocrinology 154 2013 2992 3000
7. S.C. Gunawardana, and D.W. Piston Reversal of type 1 diabetes in mice by brown adipose tissue transplant Diabetes 61 2012 674 682
8. D.W. Han, N. Tapia, A. Hermann, K. Hemmer, S. Höing, M.J. Araúzo-Bravo, H. Zaehres, G. Wu, S. Frank, S. Moritz, and et al. Direct reprogramming of fibroblasts into neural stem cells by defined factors Cell Stem Cell 10 2012 465 472
9. K. Hiramatsu, S. Sasagawa, H. Outani, K. Nakagawa, H. Yoshikawa, and N. Tsumaki Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors J. Clin. Invest. 121 2011 640 657
10. P. Huang, Z. He, S. Ji, H. Sun, D. Xiang, C. Liu, Y. Hu, X. Wang, and L. Hui Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors Nature 475 2011 386 389
11. M. Ieda, J.D. Fu, P. Delgado-Olguin, V. Vedantham, Y. Hayashi, B.G. Bruneau, and D. Srivastava Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors Cell 142 2010 375 386
12. K. Inagawa, and M. Ieda Direct reprogramming of mouse fibroblasts into cardiac myocytes J. Cardiovasc. Transl. Res. 6 2013 37 45
13. K. Inagawa, K. Miyamoto, H. Yamakawa, N. Muraoka, T. Sadahiro, T. Umei, R. Wada, Y. Katsumata, R. Kaneda, K. Nakade, and et al. Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5 Circ. Res. 111 2012 1147 1156
14. S. Kajimura, P. Seale, T. Tomaru, H. Erdjument-Bromage, M.P. Cooper, J.L. Ruas, S. Chin, P. Tempst, M.A. Lazar, and B.M. Spiegelman Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex Genes Dev. 22 2008 1397 1409
15. S. Kajimura, P. Seale, K. Kubota, E. Lunsford, J.V. Frangioni, S.P. Gygi, and B.M. Spiegelman Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex Nature 460 2009 1154 1158
16. M. Katakura, M. Hashimoto, Y. Tanabe, and O. Shido Hydrogen-rich water inhibits glucose and α,β -dicarbonyl compound-induced reactive oxygen species production in the SHR.Cg-Leprcp/NDmcr rat kidney Med. Gas Res. 2 2012 18
17. A.J. Kennedy, K.L. Ellacott, V.L. King, and A.H. Hasty Mouse models of the metabolic syndrome Dis. Model. Mech. 3 2010 156 166
18. J. Kim, J.A. Efe, S. Zhu, M. Talantova, X. Yuan, S. Wang, S.A. Lipton, K. Zhang, and S. Ding Direct reprogramming of mouse fibroblasts to neural progenitors Proc. Natl. Acad. Sci. USA 108 2011 7838 7843
19. J. Kim, R. Ambasudhan, and S. Ding Direct lineage reprogramming to neural cells Curr. Opin. Neurobiol. 22 2012 778 784
20. Y. Kontani, Y. Wang, K. Kimura, K.I. Inokuma, M. Saito, T. Suzuki-Miura, Z. Wang, Y. Sato, N. Mori, and H. Yamashita UCP1 deficiency increases susceptibility to diet-induced obesity with age Aging Cell 4 2005 147 155
21. K.A. Lo, and L. Sun Turning WAT into BAT: a review on regulators controlling the browning of white adipocytes Biosci. Rep. 33 2013 pii: e00065
22. A. Meissner Epigenetic modifications in pluripotent and differentiated cells Nat. Biotechnol. 28 2010 1079 1088
23. M. Nakagawa, M. Koyanagi, K. Tanabe, K. Takahashi, T. Ichisaka, T. Aoi, K. Okita, Y. Mochiduki, N. Takizawa, and S. Yamanaka Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts Nat. Biotechnol. 26 2008 101 106
24. Y.J. Nam, K. Song, X. Luo, E. Daniel, K. Lambeth, K. West, J.A. Hill, J.M. DiMaio, L.A. Baker, R. Bassel-Duby, and E.N. Olson Reprogramming of human fibroblasts toward a cardiac fate Proc. Natl. Acad. Sci. USA 110 2013 5588 5593
25. M. Nishio, T. Yoneshiro, M. Nakahara, S. Suzuki, K. Saeki, M. Hasegawa, Y. Kawai, H. Akutsu, A. Umezawa, K. Yasuda, and et al. Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer Cell Metab. 16 2012 394 406
26. S.P. O'Brien, M. Smith, H. Ling, L. Phillips, W. Weber, J. Lydon, C. Maloney, S. Ledbetter, C. Arbeeny, and S. Wawersik Glomerulopathy in the KK.Cg-A(y) /J mouse reflects the pathology of diabetic nephropathy J. Diabetes Res. 2013 2013 498925
27. V. Ouellet, A. Routhier-Labadie, W. Bellemare, L. Lakhal-Chaieb, E. Turcotte, A.C. Carpentier, and D. Richard Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans J. Clin. Endocrinol. Metab. 96 2011 192 199
28. V. Ouellet, S.M. Labbé, D.P. Blondin, S. Phoenix, B. Guérin, F. Haman, E.E. Turcotte, D. Richard, and A.C. Carpentier Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans J. Clin. Invest. 122 2012 545 552
29. Z.P. Pang, N. Yang, T. Vierbuchen, A. Ostermeier, D.R. Fuentes, T.Q. Yang, A. Citri, V. Sebastiano, S. Marro, T.C. Südhof, and M. Wernig Induction of human neuronal cells by defined transcription factors Nature 476 2011 220 223
30. B. Papp, and K. Plath Reprogramming to pluripotency: stepwise resetting of the epigenetic landscape Cell Res. 21 2011 486 501
31. M. Saito, Y. Okamatsu-Ogura, M. Matsushita, K. Watanabe, T. Yoneshiro, J. Nio-Kobayashi, T. Iwanaga, M. Miyagawa, T. Kameya, K. Nakada, and et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity Diabetes 58 2009 1526 1531
32. P. Seale, S. Kajimura, W. Yang, S. Chin, L.M. Rohas, M. Uldry, G. Tavernier, D. Langin, and B.M. Spiegelman Transcriptional control of brown fat determination by PRDM16 Cell Metab. 6 2007 38 54
33. P. Seale, B. Bjork, W. Yang, S. Kajimura, S. Chin, S. Kuang, A. Scimè, S. Devarakonda, H.M. Conroe, H. Erdjument-Bromage, and et al. PRDM16 controls a brown fat/skeletal muscle switch Nature 454 2008 961 967
34. S. Sekiya, and A. Suzuki Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors Nature 475 2011 390 393
35. K.I. Stanford, R.J. Middelbeek, K.L. Townsend, D. An, E.B. Nygaard, K.M. Hitchcox, K.R. Markan, K. Nakano, M.F. Hirshman, Y.H. Tseng, and L.J. Goodyear Brown adipose tissue regulates glucose homeostasis and insulin sensitivity J. Clin. Invest. 123 2013 215 223
36. E. Szabo, S. Rampalli, R.M. Risueño, A. Schnerch, R. Mitchell, A. Fiebig-Comyn, M. Levadoux-Martin, and M. Bhatia Direct conversion of human fibroblasts to multilineage blood progenitors Nature 468 2010 521 526
37. K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
38. K. Takahashi, K. Tanabe, M. Ohnuki, M. Narita, T. Ichisaka, K. Tomoda, and S. Yamanaka Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861 872
39. M. Thier, P. Wörsdörfer, Y.B. Lakes, R. Gorris, S. Herms, T. Opitz, D. Seiferling, T. Quandel, P. Hoffmann, M.M. Nöthen, and et al. Direct conversion of fibroblasts into stably expandable neural stem cells Cell Stem Cell 10 2012 473 479
40. Y. Tomino Lessons from the KK-Ay mouse, a spontaneous animal model for the treatment of human type 2 diabetic nephropathy Nephrourol. Mon. 4 2012 524 529
41. K.V. Tran, O. Gealekman, A. Frontini, M.C. Zingaretti, M. Morroni, A. Giordano, A. Smorlesi, J. Perugini, R. De Matteis, A. Sbarbati, and et al. The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells Cell Metab. 15 2012 222 229
42. W.D. van Marken Lichtenbelt, J.W. Vanhommerig, N.M. Smulders, J.M. Drossaerts, G.J. Kemerink, N.D. Bouvy, P. Schrauwen, and G.J. Teule Cold-activated brown adipose tissue in healthy men N. Engl. J. Med. 360 2009 1500 1508
43. R. Wada, N. Muraoka, K. Inagawa, H. Yamakawa, K. Miyamoto, T. Sadahiro, T. Umei, R. Kaneda, T. Suzuki, K. Kamiya, and et al. Induction of human cardiomyocyte-like cells from fibroblasts by defined factors Proc. Natl. Acad. Sci. USA 110 2013 12667 12672
44. K. Yamamoto, T. Kishida, Y. Sato, K. Nishioka, A. Ejima, H. Fujiwara, T. Kubo, T. Yamamoto, N. Kanamura, and O. Mazda Direct conversion of human fibroblasts into functional osteoblasts by defined factors Proc. Natl. Acad. Sci. USA 112 2015 6152 6157