Brazilian red propolis: Phytochemical screening, antioxidant activity and effect against cancer cells

BMC Complementary and Alternative Medicine

Volumn 15, Issue 1, 2015, Pages

  de Mendonça, Izabel Cristina Gomes ^a   Porto, Isabel Cristina Celerino de Moraes ^a   do Nascimento, Ticiano Gomes ^b   de Souza, Naiana Soares ^b   Oliveira, José Marcos dos Santos ^b   Arruda, Rodolfo Elleson dos Santos ^b   Mousinho, Kristiana Cerqueira ^a   dos Santos, Aldenir Feitosa ^a   Basílio Júnior, Irinaldo Diniz ^b   Parolia, Abhishek ^c   Barreto, Francisco Stefânio ^d  

^a Direito Público pela UFAL Especialista em Direito Penal e Processual Penal pela UCDB Direito Penal no Centro Universitário CESMAC Maceió AL   (Brazil)

^b FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

^c INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^d FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

Author keywords

Antioxidant activity; Cytotoxic activity; Phenolic compounds; Red propolis

Indexed keywords

ACETIC ACID ETHYL ESTER; CATECHIN; CHALCONE DERIVATIVE; CHLOROFORM; FLAVONOID; FLAVONOL DERIVATIVE; HEXANE; PENTACYCLIC TRITERPENE; PLANT EXTRACT; RED PROPOLIS EXTRACT; TANNIN DERIVATIVE; UNCLASSIFIED DRUG; XANTHONE DERIVATIVE; ANTINEOPLASTIC AGENT; ANTIOXIDANT; PLANT MEDICINAL PRODUCT; PROPOLIS;

ANTIOXIDANT ACTIVITY; ARTICLE; BRAZILIAN RED PROPOLIS; CANCER CELL; CANCER RESISTANCE; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC50; MEDICINAL PLANT; MOLECULAR WEIGHT; PHYTOCHEMISTRY; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; PHYTOCHEMICALS; PLANT EXTRACTS; PROPOLIS;

EID: 84944414317     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/s12906-015-0888-9     Document Type: Article

References (51)

1. Carvalho AC, Perfeito JPS, Silva LV C e, Ramalho LS, Marques RFO, Silveira D. Regulation of herbal medicines in Brazil: advances and perspectives. Braz J Pharm Sci. 2011;47:467-73.
2. Franchi Jr. GC, Moraes CS, Toreti VC, Daugsch A, Nowill AE, Park YK. Comparison of effects of the ethanolic extracts of Brazilian propolis on human leukemic cells as assessed with the MTT assay. Evid Based Complement Alternat Med. 2012; doi: 10.1155/2012/918956.
3. Li F, Awale S, Tezuka Y, Kadota S. Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship. Bioorg Med Chem. 2008;15:5434-40.
4. Sawadogo WR, Schumacher M, Teiten MH, Dicato M, Diederich M. Traditional pharmacopoeia, plants and derived compounds for cancer therapy. Biochem Pharmacol. 2012;84:1225-40.
5. Tang XL. Protective effects of the ethanolic extract of Meliatoosendan fruit against colon cancer. Indian J Biochem Biophys. 2012;49:173-218.
6. Kuropatnicki AK, Szliszka E, Krol W. Historical aspects of propolis research in modern times. Evid Based Complement Alternat Med. 2013. doi: 10.1155/2013/964149.
7. Toreti VC, Sato HH, Pastore GM, Park YK. Recent progress of propolis for its biological and chemical compositions and its botanical origin Evid Based Complement Alternat Med. 2013. doi: 10.1155/2013/697390.
8. Sforcin JM, Bankova V. Propolis: is there a potential for the development of new drugs? J Ethnopharmacol. 2011;133:253-60.
9. Sawaya ACHF, Cunha IBS, Marcucci MC. Analytical methods applied to diverse types of Brazilian propolis. Chem Cent J. 2011; doi: 10.1186/1752-153X-5-27.
10. Pereira EMR. Clinical evidence of the efficacy of a mouthwash containing propolis for the control of plaque and gingivitis: A phase II study. Evid Based Complement Alternat Med. 2011. doi: 10.1155/2011/750249.
11. Cavalcante DRR. Effect of green propolis on oral epithelial dysplasia in rats. Braz J Otorhinolaryngol. 2010;77:278-84.
12. Frozza CO, Ribeiro TS, Gambato G, Menti C, Moura S, Pinto PM, et al. Proteomic analysis identifies differentially expressed proteins after red propolis treatment in Hep-2 cells. Food Chem Toxicol. 2014;63:195-204.
13. Bankova VS, Castro SL, Marcucci MC. Propolis: recent advances in chemistry and plant origin. Apidologie. 2000;31:3-15.
14. Bankova V. Chemical diversity of propolis and the problem of standardisation. J Ethnopharmacol. 2005;100:114-7.
15. Brazilian Health Surveillance Agency - ANVISA. Technical Chamber of Phytotherapy Medicines - CATEF, Brazil, 2005. http://www.anvisa.gov.br/medicamentos/catef/propolis.htm. Accessed 10 Aug 2015.
16. Bankova V. Recent trends and important developments in propolis research. Evid Based Complement Alternat Med. 2005;2:29-32.
17. Daugsch A, Fort P, Park YK. Brazilian red propolis-chemical composition and botanical origin. Evid Based Complement Alternat Med. 2008;5:435-41.
18. Grenho L, Barros J, Ferreira C, Santos VR, Monteiro FJ, Ferraz MP et al. In vitro antimicrobial activity and biocompatibility of propolis containing nanohydroxyapatite. Biomed Mater. 2015; doi: 10.1088/1748-6041/10/2/025004.
19. Ozan F, Sümer Z, Polat ZA, Er K, Ozan U, Deger O. Effect of mouthrinse containing propolis on oral microorganisms and human gingival fibroblasts. Eur J Dent. 2007;1:195-201.
20. Dota KF, Consolaro ME, Svidzinski TI, Bruschi ML. Antifungal activity of brazilian propolis microparticles against yeasts isolated from vulvovaginal candidiasis. Evid Based Complement Alternat Med. 2011. doi: 10.1093/ecam/neq029.
21. Pippi B, Lana AJ, Moraes RC, Güez CM, Machado M, de Oliveira LF, et al. In vitro evaluation of the acquisition of resistance, antifungal activity and synergism of Brazilian red propolis with antifungal drugs on candida spp. J Appl Microbiol. 2015;118:839-50.
22. Begnini KR, de Leon PMM, Thurow H, Schultze E, Campos VF, Rodrigues FM, et al. Brazilian red propolis induces apoptosis-like cell death and decreases migration potential in bladder cancer cells. Evid Based Complement Alternat Med. 2014. doi: 10.1155/2014/639856.
23. Isla MI, Dantur Y, Salas A, Danert C, Zampini C, Arias M, et al. Effect of seasonality on chemical composition and antibacterial and anti candida activities of Argentine propolis. Design of a topical formulation. Nat Prod Commun. 2012;7:131518.
24. Jorge R, Furtado NAJC, Sousa JPB, da Silva Filho AA, Gregório-Jr LE, Martins CHG, et al. Brazilian propolis: seasonal variation of the prenylated p-coumaric acids and antimicrobial activity. Pharmaceutical Biol. 2008;46:889-93.
25. Salatino A, Teixeira EW, Negri G, Message D. Origin and chemical variation of brazilian propolis. Evid Based Complement Alternat Med. 2005;2:33-8.
26. Park YK, Alencar SM, Aguiar CL. Botanical origin and chemical composition of Brazilian propolis. J Agric Food Chem. 2002;50:2502-06.
27. Silva BB, Rosalen PL, Cury JA, Ikegaki M, Souza VC, Esteves A, et al. Chemical composition and botanical origin of red propolis, a new type of brazilian propolis. Evid Based Complement Alternat Med. 2008;5:313-6.
28. Trusheva B, Popova M, Bankova V, Simova S, Marcucci MC, Miorin PL, et al. Bioactive constituents of Brazilian red propolis. Evid Based Complement Alternat Med. 2006;3:249-54.
29. Costa Silva MS. Study of the effect of some fractions of Brazilian red propolis on tumor cells proliferation. 153f. Master's dissertation, Medicine School. São Paulo, Brazil: São Paulo University; 2007.
30. Frozza COS, Garcia CSC, Gambato G, Souza MDO, Salvador M, Moura S, et al. Chemical characterization, antioxidant and cytotoxic activities of Brazilian red propolis. Food Chem Toxicol. 2013;52:137-42.
31. Li Y, Tong Y, Cao R, Tian Z, Yang B, Yang P. In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles. Int J Nanomedicine. 2014;21:1065-82.
32. Matos FJA. Introduction to Experimental Phytochemistry. 2nd ed. Fortaleza: Ed UFC; 1997.
33. Brand-Williams W, Cuvelier ME, Berset C. Use of a free radical method to evaluate antioxidant activity. Lebensm-Wiss Technol. 1995;28:25-30.
34. Firuzi O, Miri R, Asadollahi M, Eslami S, Jassbi AR. Cytotoxic, antioxidant and antimicrobial activities and phenolic contents of eleven salvia species from Iran. Iran J Pharm Res. 2013;12:801-10.
35. Righi AA, Negri G, Salatino A. Comparative chemistry of propolis from eight Brazilian localities. Evid Based Complement Alternat Med. 2013. doi: 10.1155/2013/267878.
36. Wenyingn R, Zhenhua Q, Hongwei W, Lei Z, Li Z. Flavonoids: promising anticancer agents. Med Res Rev. 2003;23:519-34.
37. Wang T, Chen L, Wu W, Long Y, Wang R. Potential cytoprotection: antioxidant defence by caffeic acid phenethyl ester against free radical-induced damage of lipids, DNA, and proteins. Can J Physiol Pharmacol. 2008;86:279-87.
38. Kuntz S, Wenzel U, Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. Eur J Nutr. 1999;38:133-42.
39. Kamei H, Koide T, Kojimam T, Hasegawa M, Terabe K, Umeda T, et al. Flavonoid-mediated tumor growth suppression demonstrated by in vivo study. Cancer Biother Radiopharm. 1996;11:193-96.
40. Mulholland PJ, Ferry DR, Anderson D, Hussain SA, Young AM, Cook JE, et al. Pre-clinical and clinical study of QC12, a water-soluble, pro-drug of quercetin. Ann Oncol. 2001;12:245-8.
41. Szliszka E, Sokół-Łȩtowska A, Kucharska AZ, Jaworska D, Czuba ZP, Król W. Ethanolic extract of polish propolis: chemical composition and trail-r2 death receptor targeting apoptotic activity against prostate cancer cells. Evid Based Complement Alternat Med. 2013. doi: 10.1155/2013/757628.
42. Kamiya T, Nishihara H, Hara H, Adachi T. Ethanol extract of Brazilian red propolis induces apoptosis in human breast cancer MCF-7 cells through endoplasmic reticulum stress. J Agric Food Chem. 2012;60:11065-70.
43. Ramos AFN, Miranda JL. Propolis: a review of its anti-inflammatory and healing actions. J Venom Anim Toxins Incl Trop Dis. 2007;13:697-710.
44. Okoh SO, Asekun OT, Familoni OB, Afolayan AJ. Antioxidant and free radical scavenging capacity of seed and shell essential oils extracted from abrus precatorius (L). Antioxidants. 2014;3:278-87.
45. Cabral ISR, Oldoni TLC, Prado A. Phenolic composition and antibacterial and antioxidant activity of Brazilian red propolis. Quim Nova. 2009;32:1523-7.
46. Zhang X, Yeung ED, Wang J, Panzhinskiy EE, Tong C, Li W, et al. Isoliquiritigenin, a natural anti-oxidant, selectively inhibits the proliferation of prostate cancer cells. Clin Exp Pharmacol Physiol. 2010;37:841-7.
47. Ondrias K, Stasko A, Hromadová M, Suchy V, Nagy M. Pinobanksin inhibits peroxidation of low density lipoprotein and it has electron donor properties reducing alpha-tocopherol radicals. DiePharmazie. 1997;52:566-7.
48. Blanco-Ayala T, Lugo-Huitrón R, Serrano-López EM, Reyes-Chilpa R, Rangel-López E, Pineda B, et al. Antioxidant properties of xanthones from Calophyllum brasiliense: prevention of oxidative damage induced by FeSO. BMC Complement Altern Med. 2013;11:213. 62.
49. Kiełbus M, Skalicka-Woźniak K, Grabarska A, Jeleniewicz W, Dmoszyńska-Graniczka M, Marston A, et al. 7-Substituted Coumarins Inhibit Proliferation and Migration of Laryngeal Cancer Cells In Vitro. Anticancer Res. 2013;33:4347-56.
50. Rashed KN, Butnariu M. Isolation and antimicrobial and antioxidant evaluation of bioactive compounds from eriobotrya japonica stems. Adv Pharm Bull. 2014;4:75-81.
51. Zhang T, Omar R, Siheri W, Al-Mutairi S, Clements C, Fearnley J, et al. Chromatographic analysis with different detectors in the chemical characterisation and dereplication of African propolis. Talanta. 2014;120:181-90.