PERK pathway is involved in oxygen-glucose-serum deprivation-induced NF-kB activation via ROS generation in spinal cord astrocytes

Biochemical and Biophysical Research Communications

Volumn 467, Issue 2, 2015, Pages 197-203

  Liu, Jinbo ^a   Du, Lijian ^b  

^a SOOCHOW UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Astrocytes; NF kB; PERK; Rat; Spinal cord injury

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHOTRANSFERASE; PROTEIN KINASE RNA LIKE ER KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; GLUCOSE; OXYGEN; PERK KINASE; PROTEIN KINASE R; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL VIABILITY; CONTROLLED STUDY; GENE SILENCING; HYPOXIA; IN VITRO STUDY; ISCHEMIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SPINAL CORD INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL HYPOXIA; CELL NUCLEUS; CELL SURVIVAL; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE VECTOR; GENETICS; LENTIVIRINAE; METABOLISM; NEWBORN; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELL HYPOXIA; CELL NUCLEUS; CELL SURVIVAL; EIF-2 KINASE; GENE EXPRESSION REGULATION; GENETIC VECTORS; GLUCOSE; LENTIVIRUS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-KAPPA B; OXYGEN; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 84944404366     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2015.10.007     Document Type: Article

References (34)

1. A. Emirandetti, G.F. Simões, R.G. Zanon, and A.L. Oliveira Spinal motoneuron synaptic plasticity after axotomy in the absence of inducible nitric oxide synthase J. Neuroinflamm. 7 2010 31
2. T.G. Bush, N. Puvanachandra, C.H. Horner, A. Polito, T. Ostenfeld, C.N. Svendsen, L. Mucke, M.H. Johnson, and M.V. Sofroniew Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice Neuron 23 1999 297 308
3. A. Zhang, J. Zhang, P. Sun, C. Yao, C. Su, T. Sui, H. Huang, X. Cao, and Y. Ge EIF2alpha and caspase-12 activation are involved in oxygen-glucose-serum deprivation/restoration-induced apoptosis of spinal cord astrocytes Neurosci. Lett. 478 2010 32 36
4. 2+ handling and function of mitochondria in astrocytes after ischemia-like stress Mitochondrion 11 2011 279 286
5. S. Swarnkar, S. Singh, P. Goswami, R. Mathur, I.K. Patro, and C. Nath Astrocyte activation: a key step in rotenone induced cytotoxicity and DNA damage Neurochem. Res. 37 2012 2178 2189
6. R. Cabezas, R.S. El-Bachá, J. González, and G.E. Barreto Mitochondrial functions in astrocytes: neuroprotective implications from oxidative damage by rotenone Neurosci. Res. 13 2012 3510 3524
7. G. Liu, J. Zhao, Z. Chang, and G. Guo CaMKII activates ASK1 to induce apoptosis of spinal astrocytes under oxygen-glucose deprivation Cell. Mol. Neurobiol. 33 2013 543 549
8. K. Park, Y. Lee, S. Park, S. Lee, Y. Hong, S. Kil Lee, and Y. Hong Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model J. Pineal Res. 48 2010 270 281
9. Y. Hamada, T. Ikata, S. Katoh, K. Nakauchi, M. Niwa, Y. Kawai, and K. Fukuzawa Involvement of an intercellular adhesion molecule 1-dependent pathway in the pathogenesis of secondary changes after spinal cord injury in rats J. Neurochem. 66 1996 1525 1531
10. E.K. Kwak, J.W. Kim, K.S. Kang, Y.H. Lee, Q.H. Hua, T.I. Park, J.Y. Park, and Y.K. Sohn The role of inducible nitric oxide synthase following spinal cord injury in rat J. Korean Med. Sci. 20 2005 663 669
11. J. Guo, S.P. Duckles, J.H. Weiss, X. Li, and D.N. Krause 17 β-Estradiol prevents cell death and mitochondrial dysfunction by an estrogen receptor-dependent mechanism in astrocytes after oxygen-glucose deprivation/reperfusion Free Radic. Biol. Med. 52 2012 2151 2160
12. A. Gorlach, P. Klappa, and T. Kietzmann The endoplasmic reticulum: folding, calcium homeostasis, signaling, and redox control Antioxid. Redox Signal. 8 2006 1391 1418
13. J. Castellano, J. Farré, J. Fernandes, A. Bayes-Genis, J. Cinca, L. Badimon, L. Hove-Madsen, and V. Llorente-Cortés Hypoxia exacerbates Ca(2+)-handling disturbances induced by very low density lipoproteins (VLDL) in neonatal rat cardiomyocytes J. Mol. Cell. Cardiol. 50 2011 894 902
14. T. Hayashi, R. Rizzuto, G. Hajnoczky, and T.P. Su MAM: more than just a housekeeper Trends Cell Biol. 19 2009 81 88
15. T. Verfaillie, N. Rubio, A.D. Garg, G. Bultynck, R. Rizzuto, J.P. Decuypere, J. Piette, C. Linehan, S. Gupta, A. Samali, and P. Agostinis PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress Cell Death Differ. 19 2012 1880 1891
16. N. Haan, B. Zhu, J. Wang, X. Wei, and B. Song Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury J. Neuroinflamm. 12 2015 109
17. R. Brambilla, A. Hurtado, T. Persaud, K.K. Esham, D.D. Pearse, M. Oudega, and J.R. Bethea Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury J. Neurochem. 110 2009 765 778
18. L. Zhang, Z. Li, W. He, L. Xu, J. Wang, J. Shi, and M. Sheng Effects of astragaloside IV against the TGF-β1-induced epithelial-to-mesenchymal transition in peritoneal mesothelial cells by promoting Smad 7 expression Cell. Physiol. Biochem. 37 2015 43 54
19. S.J. Cooney, Y. Zhao, and K.R. Byrnes Characterization of the expression and inflammatory activity of NADPH oxidase after spinal cord injury Free Radic. Res. 48 2014 929 939
20. J.F. Wang, Y. Li, J.N. Song, and H.G. Pang Role of hydrogen sulfide in secondary neuronal injury Neurochem. Int. 64 2014 37 47
21. C.C. Wang, K.M. Fang, C.S. Yang, and S.F. Tzeng Reactive oxygen species-induced cell death of rat primary astrocytes through mitochondria-mediated mechanism J. Cell. Biochem. 107 2009 933 943
22. C.X. Santos, A.A. Nabeebaccus, A.M. Shah, L.L. Camargo, S.V. Filho, and L.R. Lopes Endoplasmic reticulum stress and Nox-mediated reactive oxygen species signaling in the peripheral vasculature: potential role in hypertension Antioxid. Redox Signal. 20 2014 121 134
23. Z. Nayernia, V. Jaquet, and K.H. Krause New insights on NOX enzymes in the central nervous system Antioxid. Redox Signal 20 2014 2815 2837
24. W.S. Sheng, S. Hu, A. Feng, and R.B. Rock Reactive oxygen species from human astrocytes induced functional impairment and oxidative damage Neurochem. Res. 38 2013 2148 2159
25. 2+ loads in cortical neurons PLoS One 8 2013 e83347
26. H.P. Harding, Y. Zhang, A. Bertolotti, H. Zeng, and D. Ron Perk is essential for translational regulation and cell survival during the unfolded protein response Mol. Cell 5 2000 897 904
27. S. Takayanagi, R. Fukuda, Y. Takeuchi, S. Tsukada, and K. Yoshida Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress Cell Stress Chaperones 18 2013 11 23
28. R. Sano, and J.C. Reed ER stress-induced cell death mechanisms Biochim. Biophys. Acta 1833 2013 3460 3470
29. 2+ regulation in secretory and muscle cells from PERK-knockout mice J. Cell Sci. 119 2006 153 161
30. K. Shi, D. Wang, X. Cao, and Y. Ge Endoplasmic reticulum stress signaling is involved in mitomycin C (MMC)-induced apoptosis in human fibroblasts via PERK pathway PLoS One 8 2013 e59330
31. K.M. Rouschop, L.J. Dubois, T.G. Keulers, T. van den Beucken, P. Lambin, J. Bussink, A.J. van der Kogel, M. Koritzinsky, and B.G. Wouters PERK/eIF2α signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS Proc. Natl. Acad. Sci. U. S. A. 110 2013 4622 4627
32. Y. Zhou, Y. Zhou, S. Yu, J. Wu, Y. Chen, and Y. Zhao Sulfiredoxin-1 exerts anti-apoptotic and neuroprotective effects against oxidative stress-induced injury in rat cortical astrocytes following exposure to oxygen-glucose deprivation and hydrogen peroxide Int. J. Mol. Med. 36 2015 43 52
33. Y.P. Yen, K.S. Tsai, Y.W. Chen, C.F. Huang, R.S. Yang, and S.H. Liu Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway Arch. Toxicol. 86 2012 923 933
34. X. Yin, H. Sun, D. Yu, Y. Liang, Z. Yuan, and Y. Ge Hydroxycamptothecin induces apoptosis of human tenon's capsule fibroblasts by activating the PERK signaling pathway Investig. Ophthalmol. Vis. Sci. 54 2013 4749 4758