Quercetin enhances chemosensitivity to gemcitabine in lung cancer cells by inhibiting heat shock protein 70 expression

Clinical Lung Cancer

Volumn 16, Issue 6, 2015, Pages e235-e243

  Lee, Seung Hyeun ^a   Lee, Eun Joo ^b   Min, Kyung Hoon ^b   Hur, Gyu Young ^b   Lee, Seung Heon ^b   Lee, Sung Yong ^b   Kim, Je Hyeong ^b   Shin, Chol ^b   Shim, Jae Jeong ^b   In, Kwang Ho ^b   Kang, Kyung Ho ^b   Lee, Sang Yeub ^b  

^a Korea Electric Power Research Institute (KEPRI)   (South Korea)

^b College of Medicine   (South Korea)

Author keywords

Apoptosis; Gemcitabine; Heat shock protein; Lung cancer; Quercetin

Indexed keywords

CASPASE 3; CASPASE 9; GEMCITABINE; HEAT SHOCK PROTEIN 70; QUERCETIN; CASPASE; DEOXYCYTIDINE; PHARMACOLOGICAL BIOMARKER;

A549 CELL LINE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IC50; LUNG CANCER; PROTEIN EXPRESSION; ADENOCARCINOMA; ANALOGS AND DERIVATIVES; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; APOPTOSIS; BIOMARKERS, PHARMACOLOGICAL; CASPASES; CELL LINE, TUMOR; DEOXYCYTIDINE; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; LUNG NEOPLASMS; QUERCETIN;

EID: 84944351631     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.1016/j.cllc.2015.05.006     Document Type: Article

References (41)

1. A. Jemal, R. Siegel, J. Xu, and et al. Cancer statistics, 2010 CA Cancer J Clin 60 2010 277 300
2. X.L. Fu, X.Z. Zhu, D.R. Shi, and et al. Study of prognostic predictors for non-small-cell lung cancer Lung Cancer 23 1999 143 152
3. F. Ritossa Discovery of the heat shock response Cell Stress Chaperones 1 1996 97 98
4. L.M. Vargas-Roig, F.E. Gago, O. Tello, and et al. Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy Int J Cancer 79 1998 468 475
5. J. Nylandsted, M. Rohde, K. Brand, and et al. Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2 Proc Natl Acad Sci U S A 97 2000 7871 7876
6. A. Aghdassi, P. Phillips, V. Dudeja, and et al. Heat shock protein 70 increases tumorigenicity and inhibits apoptosis in pancreatic adenocarcinoma Cancer Res 67 2007 616 625
7. J. Kaur, and R. Ralhan Induction of apoptosis by abrogation of HSP70 expression in human oral cancer cells Int J Cancer 85 2000 1 5
8. S. Yang, J. Chen, Z. Guo, and et al. Triptolide inhibits the growth and metastasis of solid tumors Mol Cancer Ther 2 2003 65 72
9. Q. Huang, Y. Zu, X. Fu, and et al. Expression of heat shock protein 70 and 27 in non-small-cell lung cancer and its clinical significance J Huazhong Univ Sci Technolog Med Sci 25 2005 693 695
10. K. Suzuki, Y. Ito, K. Wakai, and et al. Serum heat shock protein 70 levels and lung cancer risk: a case-control study nested in a large cohort study Cancer Epidemiol Biomarkers Prev 15 2006 1733 1737
11. M.G. Hertog, P.C. Hollman, M.B. Katan, and et al. Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands Nutr Cancer 20 1993 21 29
12. J.A. Choi, J.Y. Kim, J.Y. Lee, and et al. Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin Int J Oncol 19 2001 837 844
13. S. Chirumbolo The role of quercetin, flavonols and flavones in modulating inflammatory cell function Inflamm Allergy Drug Targets 9 2010 263 285
14. K. Ishizawa, M. Yoshizumi, Y. Kawai, and et al. Pharmacology in health food: metabolism of quercetin in vivo and its protective effect against arteriosclerosis J Pharmacol Sci 115 2011 466 470
15. M. Russo, C. Spagnuolo, I. Tedesco, and et al. The flavonoid quercetin in disease prevention and therapy: facts and fancies Biochem Pharmacol 83 2012 6 15
16. L.M. Larocca, F.O. Ranelletti, N. Maggiano, and et al. Differential sensitivity of leukemic and normal hematopoietic progenitors to the killing effect of hyperthermia and quercetin used in combination: role of heat-shock protein-70 Int J Cancer 73 1997 75 83
17. Y.Q. Wei, X. Zhao, Y. Kariya, and et al. Induction of apoptosis by quercetin: involvement of heat shock protein Cancer Res 54 1994 4952 4957
18. J.S. Choi, B.W. Jo, and Y.C. Kim Enhanced paclitaxel bioavailability after oral administration of paclitaxel or prodrug to rats pretreated with quercetin Eur J Pharm Biopharm 57 2004 313 318
19. J. Jakubowicz-Gil, R. Paduch, T. Piersiak, and et al. The effect of quercetin on pro-apoptotic activity of cisplatin in HeLa cells Biochem Pharmacol 69 2005 1343 1350
20. V.C. de Boer, A.A. Dihal, H. van der Woude, and et al. Tissue distribution of quercetin in rats and pigs J Nutr 135 2005 1718 1725
21. M.A. Avila, J.A. Velasco, J. Cansado, and et al. Quercetin mediates the down-regulation of mutant p53 in the human breast cancer cell line MDA-MB468 Cancer Res 54 1994 2424 2428
22. C.S. Ong, E. Tran, T.T. Nguyen, and et al. Quercetin-induced growth inhibition and cell death in nasopharyngeal carcinoma cells are associated with increase in Bad and hypophosphorylated retinoblastoma expressions Oncol Rep 11 2004 727 733
23. J.H. Yang, T.C. Hsia, H.M. Kuo, and et al. Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis Drug Metab Dispos 34 2006 296 304
24. F.O. Ranelletti, R. Ricci, L.M. Larocca, and et al. Growth-inhibitory effect of quercetin and presence of type-II estrogen-binding sites in human colon-cancer cell lines and primary colorectal tumors Int J Cancer 50 1992 486 492
25. T.T. Nguyen, E. Tran, T.H. Nguyen, and et al. The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells Carcinogenesis 25 2004 647 659
26. N. Hosokawa, K. Hirayoshi, H. Kudo, and et al. Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids Mol Cell Biol 12 1992 3490 3498
27. S.M. Kuo Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells Cancer Lett 110 1996 41 48
28. J. Jakubowicz-Gil, J. Rzymowska, and A. Gawron Quercetin, apoptosis, heat shock Biochem Pharmacol 64 2002 1591 1595
29. C. Chen, J. Zhou, and C. Ji Quercetin: a potential drug to reverse multidrug resistance Life Sci 87 2010 333 338
30. G. Kroemer, and J.C. Reed Mitochondrial control of cell death Nat Med 6 2000 513 519
31. P. Li, D. Nijhawan, I. Budihardjo, and et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade Cell 91 1997 479 489
32. H. Youn, J.C. Jeong, Y.S. Jeong, and et al. Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells Biol Pharm Bull 36 2013 944 951
33. B.J. Braakhuis, G.A. van Dongen, J.B. Vermorken, and et al. Preclinical in vivo activity of 2′,2′-difluorodeoxycytidine (gemcitabine) against human head and neck cancer Cancer Res 51 1991 211 214
34. L. León, J.F. Cueva-Banuelos, G. Huidobro, and et al. Gemcitabine, cisplatin and vinorelbine as induction chemotherapy followed by radical therapy in stage III non-small-cell lung cancer: a multicentre study of Galician-Lung-Cancer-Group Lung Cancer 40 2003 215 220
35. P. Sève, and C. Dumontet Chemoresistance in non-small-cell lung cancer Curr Med Chem Anticancer Agents 5 2005 73 88
36. G. Sliutz, J. Karlseder, C. Tempfer, and et al. Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy Br J Cancer 74 1996 172 177
37. J.J. Hyun, H.S. Lee, B. Keum, and et al. Expression of heat shock protein 70 modulates the chemoresponsiveness of pancreatic cancer Gut Liver 7 2013 739 746
38. P.A. Phillips, V. Dudeja, J.A. McCarroll, and et al. Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70 Cancer Res 67 2007 9407 9416
39. W. Wen, W. Liu, Y. Shao, and et al. VER-155008, a small molecule inhibitor of HSP70 with potent anti-cancer activity on lung cancer cell lines Exp Biol Med (Maywood) 239 2014 638 645
40. H. Endo, M. Yano, Y. Okumura, and et al. Ibuprofen enhances the anticancer activity of cisplatin in lung cancer cells by inhibiting the heat shock protein 70 Cell Death Dis 5 2014 e1027
41. R. Chugh, V. Sangwan, S.P. Patil, and et al. A preclinical evaluation of Minnelide as a therapeutic agent against pancreatic cancer Sci Transl Med 4 2012 156ra39