Dynamics of the HPA axis and inflammatory cytokines: Insights from mathematical modeling

Computers in Biology and Medicine

Volumn 67, Issue , 2015, Pages 1-12

  Malek, Hamed ^a   Ebadzadeh, Mohammad Mehdi ^a   Safabakhsh, Reza ^a   Razavi, Alireza ^b   Zaringhalam, Jalal ^c  

^a AMIRKABIR UNIVERSITY OF TECHNOLOGY   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Hypothalamic pituitary adrenal (HPA) axis; Immune system; Inflammatory cytokines; Mathematical model; Nervous system

Indexed keywords

CORTISOL; DIFFERENTIAL EQUATIONS; ENDOCRINOLOGY; HORMONES; MARKOV PROCESSES; MATHEMATICAL MODELS; MONTE CARLO METHODS; NEUROLOGY; PATHOLOGY; UNCERTAINTY ANALYSIS;

BI-DIRECTIONAL COMMUNICATION; COMPLEX RELATIONSHIPS; DELAY DIFFERENTIAL EQUATIONS; HYPOTHALAMIC-PITUITARY-ADRENAL AXIS; INFLAMMATORY CYTOKINES; MARKOV CHAIN MONTE CARLO METHOD; PARAMETER UNCERTAINTY; PRO-INFLAMMATORY CYTOKINES;

IMMUNE SYSTEM;

BACTERIUM LIPOPOLYSACCHARIDE; CORTICOTROPIN; HYDROCORTISONE; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA; IMMUNOLOGIC FACTOR; LIPOPOLYSACCHARIDE;

ADRENAL CORTEX; ADULT; ANTIBODY PRODUCTION; ARTICLE; CIRCADIAN RHYTHM; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN RELEASE; CYTOKINE PRODUCTION; DOWN REGULATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; MALE; MATHEMATICAL MODEL; MONTE CARLO METHOD; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROBABILITY; STEADY STATE; ULTRADIAN RHYTHM; ANIMAL; BIOLOGICAL MODEL; CHEMICALLY INDUCED; COMPUTER SIMULATION; DRUG EFFECTS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; IMMUNOLOGY; RAT; STATISTICAL MODEL;

ANIMALS; COMPUTER SIMULATION; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; IMMUNOLOGIC FACTORS; INFLAMMATION; LIPOPOLYSACCHARIDES; MODELS, IMMUNOLOGICAL; MODELS, STATISTICAL; MONTE CARLO METHOD; PITUITARY-ADRENAL SYSTEM; RATS;

EID: 84944312454     PISSN: 00104825     EISSN: 18790534     Source Type: Journal    
DOI: 10.1016/j.compbiomed.2015.09.018     Document Type: Article

References (47)

1. M. Andersen, F. Vinther, J.T. Ottesen, Mathematical modeling of the hypothalamicpituitary-adrenal gland (HPA) axis, including hippocampal mechanisms, Math. Biosci. 246(1 (November)) (2013) 122-138. ISSN: 1879-3134. http://dx.doi.org/10.1016/j.mbs.2013.08.010.
2. J. Axelrod, T.D. Reisine, Stress hormones: their interaction and regulation, Science (New York, N.Y.) 224 (4648 (May)) (1984) 452-459. ISSN: 0036-8075.
3. N Bairagi, S. Chatterjee, J. Chattopadhyay, Variability in the secretion of corticotropin releasing hormone, adrenocorticotropic hormone and cortisol and understandability of the hypothalamic-pituitary-adrenal axis dynamics-a mathematical study based on clinical evidence, Math. Med. Biol.: J. IMA 25 (1 (March)) (2008) 37-63. ISSN: 1477-8602. http://dx.doi.org/10.1093/imammb/dqn003.
4. M. Baker et al., Mathematical modeling of cytokine-mediated inflammation in rheumatoid arthritis, Math. Med. Biol. 30 (4 (September)) (2012) 311-337. ISSN: 1477-8599 1477-8602. URL: 〈〉(visited on 02/05/2014). http://www.bionity.com/en/publications/624182/mathematical-modeling-of-cytokine-mediated-inflammation-in-rheumatoidarthritis.html.
5. M. Barney et al., Stimulation by interleukin-6 and inhibition by tumor necrosis factor of cortisol release from bovine adrenal zona fasciculata cells through their receptors, Endocrine 13 (3 (December)) (2000) 369-377. ISSN: 1355-008X. http://dx.doi.org/10.1385/ENDO:13:3:369.
6. B.J. Carroll et al., Pathophysiology of hypercortisolism in depression, Acta Psych. Scand. 433 (Supplementum) (2007), 90-103. ISSN: 0065-1591. http://dx.doi.org/10.1111/j.1600-0447.2007.00967.x.
7. G.P. Chrousos, The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation, New Engl. J. Med. 332 (20 (May)) (1995) 1351-1362. ISSN: 0028-4793.
8. M. Clodi et al., Oxytocin alleviates the neuroendocrine and cytokine response to bacterial endotoxin in healthy men, Am. J. Physiol. Endocrinol. Metab. 295 (3 (September)) (2008) E686-691. ISSN: 0193-1849. http://dx.doi.org/10.1152/ajpendo.90263.2008.
9. J. Day et al., A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration, J. Theor. Biol. 242 (1 (September)) (2006), 237-256. ISSN: 0022-5193. 〈〉. http://dx.doi.org/10.1016/j.jtbi.2006.02.015.
10. D. Engler et al., Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. I. Effect of an audiovisual stimulus and insulin-induced hypoglycemia, Neuroendocrinology 49(4 (April)) (1989), 367-381. ISSN: 0028-3835.
11. R.E. Faith et al., Cytokines: Stress and Immunity, Second edition. CRC Press, Boca Raton, October 10, 2006, p. 456. ISBN: 9781420003802.
12. P. Gregory, Bayesian Logical Data Analysis for the Physical Sciences: A Comparative Approach with Mathematica Support, Cambridge University Press, Cambridge, April 14, 2005, p. 496. ISBN: 9781139444286.
13. S. Gupta et al., Inclusion of the glucocorticoid receptor in a hypothalamic pituitary adrenal axis model reveals bistability, Theor. Biol. Med. Model. (4 (February)) (2007) 8. ISSN: 1742-4682. URL:〈, 〉(visited on 10/19/2014). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1804264/.
14. H. Imura, J. Fukata, T. Mori, Cytokines and endocrine function: an interaction between the immune and neuroendocrine systems, Clin. Endocrinol. 35 (2 (August)) (1991) 107-115. ISSN: 0300-0664.
15. D.M. Jablons et al., IL-6/IFN-beta-2 as a circulating hormone. Induction by cytokine administration in humans, J. Immunol. (Baltimore, Md.: 1950) 142 (5 (March)) (1989) 1542-1547. ISSN: 0022-1767.
16. S. Jelic, Z. Cupic, L. Kolar-Ani, Mathematical modeling of the hypothalamicpituitary-adrenal system activity, Math. Biosci. 197 (2 (October)) (2005) 173-187. ISSN: 0025-5564. http://dx.doi.org/10.1016/j.mbs.2005.06.006.
17. M. Jttel et al., Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells, Endocrinology 128 (1 (January)) (1991) 623-629. ISSN: 0013-7227. http://dx.doi.org/10.1210/endo-128-1-623.
18. A. Kalsbeek et al., Circadian rhythms in the hypothalamopituitaryadrenal (HPA) axis. The role of circadian clock in endocrinology, Mol. Cell. Endocrinol. 349 (1 (February)) (2012) 20-29. ISSN: 0303-7207. 〈〉, 〈〉(visited on 10/19/2014). http://www.sciencedirect.com/science/article/pii/S0303720711003753.
19. T. Kawli, F. He, M.-W. Tan, It takes nerves to fight infections: insights on neuroimmune interactions from C. elegans.Dis. Models Mech. 3(11) (2010) 721-731. ISSN: 1754-8403. URL: 〈〉(visited on 05/23/2014). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965399/.
20. R. Kumar et al., The dynamics of acute inflammation. J. Theor. Biol. 230 (2 (September)) (2004) 145-155. ISSN: 0022-5193. URL: 〈〉(visited on 11/08/2014). http://www.sciencedirect.com/science/article/pii/S0022519304001845.
21. Y. Lenbury, P. Pornsawad, A delay-differential equation model of the feedbackcontrolled hypothalamus-pituitary-adrenal axis in humans, Math. Med. Biol.: J. IMA 22(1 (March)) (2005) 15-33. ISSN: 1477-8599. http://dx.doi.org/10.1093/imammb/dqh020.
22. A. Marques-Deak, G. Cizza, E. Sternberg, Brain-immune interactions and disease susceptibility, Mol. Psych. 10 (3 (February)) (2005) 239-250. ISSN: 1359-4184. DOI: 10.1038/sj.mp.4001643. 〈〉(visited on 05/23/2014). http://www.nature.com/mp/journal/v10/n3/full/4001643a.html.
23. A.K. Abbas, A.H.H. Lichtman, S. Pillai, Cellular and Molecular Immunology, 8e, 8 edition, Saunders, Philadelphia, PA, August 28, 2014, p. 544. ISBN:9780323222754.
24. M.J. van der Meer et al., Acute stimulation of the hypothalamic-pituitary-adrenal axis by IL-1 beta, TNF alpha and IL-6: a dose response study, J. Endocrinol. Invest. 19 (3 (March) (1996) 175-182. ISSN: 0391-4097.
25. M.J. Van der Meer et al., Synergism between IL-1 beta and TNF-alpha on the activity of the pituitary-adrenal axis and on food intake of rats, Am. J. Physiol. 268 (4 (April)) (1995) E551-557. ISSN: 0002-9513.
26. H. Mhlenbein, G. Paa, From recombination of genes to the estimation of distributions I. Binary parameters, in: H.-M. Voigt et al. (Ed.) Parallel Problem Solving from Nature PPSN IV. Lecture Notes in Computer Science, vol. 1141, Springer, Berlin, Heidelberg, 1996, pp. 178-187. ISBN: 978-3-540-61723-5, 978-3-540-70668-7. URL: 〈〉(visited on 07/04/2015). http://link.springer.com/chapter/10.1007/3-540-61723-X_982.
27. N.A.M. Monk, Oscillatory Expression of Hes1, p53, and NF-B Driven by Transcriptional Time Delays, Curr. Biol. 13 (16 (August)) (2003) 1409-1413. ISSN: 0960-9822. URL: 〈〉(visited on 04/04/2015). http://www.cell.com/article/S0960982203004949/abstract.
28. K. Mori et al., Autoinduction of tumor necrosis factor-alpha in FRTL-5 rat thyroid cells, J. Endocrinol. 187 (1 (October)) (2005) 17-24. ISSN: 0022-0795. http://dx.doi.org/10.1677/joe.1.05887.
29. J.D. Murray, Mathematical Biology. Interdisciplinary Applied Mathematics. vol. 17, Springer New York, New York, NY, 2004. ISBN: 978-0-387-95223-9. 〈〉(visited on 07/02/2015). http://link.springer.com/10.1007/b98868.
30. G.L. Nicolson, M.Y. Nasralla, N.L. Nicolson, The pathogenesis and treatment of mycoplasmal infections, Antimicrob. Infect. Dis. Newslett. 17 (11 (November)) (1998) 81-87. ISSN: 1069-417X. URL: 〈〉(visited on 08/29/2015). http://www.sciencedirect.com/science/article/pii/S1069417X00888858.
31. G. Nieman et al., A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine, Crit, Care Med. 40 (4 (April)) (2012) 1052-1063. ISSN: 1530-0293. http://dx.doi.org/10.1097/CCM.0b013e31823e986a.
32. J.C. Oliver et al., Cytokine kinetics in an in vitro whole blood model following an endotoxin challenge, Lymphokine Cytokine Res. 12 (2 (April)) (1993) 115-120. ISSN: 1056-5477.
33. T.K. Paul, H. Iba, Real-coded estimation of distribution algorithm, in: Proceedings of The Fifth Metaheuristics International Conference, 2003.
34. R.S. Perlstein et al., Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo, Endocrinology 132 (3 (March)) (1993) 946-952. ISSN: 0013-7227. http://dx.doi.org/10.1210/endo.132.3.8382602.
35. J.A. Posener et al., Cortisol feedback effects on plasma corticotropin levels in healthy subjects, Psychoneuroendocrinology 22 (3 (April)) (1997) 169-176. ISSN: 0306-4530.
36. H. Selye, A syndrome produced by diverse nocuous agents. 1936, J. Neuropsych. Clin. Neurosci. 10 (2) (1998) 230-231. ISSN: 0895-0172.
37. M.N. Silverman et al., Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection, Viral Immunol. 18 (1) (2005) 41-78. ISSN:0882-8245. URL: 〈〉(visited on 01/12/2014). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224723/.
38. D.R. Spriggs et al., Phospholipase A2 activation and autoinduction of tumor necrosis factor gene expression by tumor necrosis factor, Cancer Res. 50(22 (November) (1990) 7101-7107. ISSN: 0008-5472 1538-7445. 〈〉(visited on 07/01/2015). http://cancerres.aacrjournals.org/content/50/22/7101.
39. K. Sriram, M. Rodriguez-Fernandez, F.J. Doyle, Modeling cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and Post-traumatic Stress Disorder (PTSD) in humans, PLoS Comput. Biol. 8 (2 (February) (2012). ISSN: 1553-734X. URL: 〈〉(visited on 02/04/2014). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280965/.
40. E.M. Sternberg, Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens, Nat. Rev. Immunol. 6 (4 (April)) (2006) 318-328. ISSN: 1474-1733. URL: 〈〉(visited on 05/23/2014). http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1783839/.
41. H. Tilg et al., Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55, Blood 83(1 (January)) (1994) 113-118. ISSN: 0006-4971.
42. F. Vinther, M. Andersen, J.T. Ottesen, The minimal model of the hypothalamicpituitary- adrenal axis, J. Math. Biol. 63 (4 (October)) (2011) 663-690. ISSN: 1432-1416. http://dx.doi.org/10.1007/s00285-010-0384-2.
43. Y. Vodovotz et al., Mathematical models of the acute inflammatory response, Curr. Opin. Crit. Care 10 (5 (October)) (2004) 383-390. ISSN: 1070-5295.
44. J.J. Walker, J.R. Terry, S.L. Lightman, Origin of ultradian pulsatility in the hypothalamicpituitaryadrenal axis, Proc. R. Soc. B: Biol. Sci. 277 (1688 (June)) (2010) 1627-1633. ISSN: 0962-8452, 1471-2954 (visited on 10/13/2014). URL: 〈〉. http://rspb.royalsocietypublishing.org/content/277/1688/1627.
45. J.J. Walker et al., The origin of glucocorticoid hormone oscillations, PLoS Biol. 10 (6 (June)) (2012) e1001341 (visited on 10/13/2014). http://dx.doi.org/10.1371/journal.pbio.1001341.
46. C. Weigert et al., Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms, Am. J. Physiol. - Cell Physiol. 293 (3 (September)) (2007) C1139-C1147 (visited on 11/23/2013). URL: 〈〉. http://ajpcell.physiology.org/content/293/3/C1139.
47. Z Xing et al., IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses, J. Clin. Investig. 101 (2 (January)) (1998) 311-320. ISSN: 0021-9738. http://dx.doi.org/10.1172/JCI1368.