Modeling cortisol dynamics in the neuro-endocrine axis distinguishes normal, depression, and post-traumatic stress disorder (PTSD) in humans

PLoS Computational Biology

Volumn 8, Issue 2, 2012, Pages

  Sriram, K ^a,b   Rodriguez Fernandez, Maria ^a,b   Doyle III, Francis J ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIFURCATION (MATHEMATICS); CORTISOL; FEEDBACK; GLOBAL OPTIMIZATION; KINETIC PARAMETERS; NONLINEAR EQUATIONS;

ADRENAL CORTEX; BIFURCATION ANALYSIS; GLOBAL OPTIMISATION; HUMAN SUBJECTS; KINETICS PARAMETER; MAJOR DEPRESSIONS; NEGATIVE FEEDBACK LOOP; NONLINEAR ORDINARY DIFFERENTIAL EQUATION; POSTTRAUMATIC STRESS DISORDER; THREE CATEGORIES;

ORDINARY DIFFERENTIAL EQUATIONS;

CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; BIOLOGICAL MARKER;

ACCURACY; ALGORITHM; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; DEPRESSION; DOWN REGULATION; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MALE; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NEGATIVE FEEDBACK; NONLINEAR SYSTEM; PHENOTYPIC VARIATION; POSTTRAUMATIC STRESS DISORDER; PREDICTION; SENSITIVITY AND SPECIFICITY; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION; SIMULATION; TIME SERIES ANALYSIS; BIOLOGICAL MODEL; BIOLOGY; COMORBIDITY; ENDOCRINE SYSTEM; KINETICS; MENTAL STRESS; METABOLISM; METHODOLOGY; NEUROSECRETION; PHENOTYPE; PHYSIOLOGY; STATISTICAL MODEL;

BIOLOGICAL MARKERS; COMORBIDITY; COMPUTATIONAL BIOLOGY; DEPRESSION; ENDOCRINE SYSTEM; HUMANS; HYDROCORTISONE; KINETICS; MODELS, BIOLOGICAL; MODELS, STATISTICAL; NEUROSECRETORY SYSTEMS; PHENOTYPE; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL;

EID: 84861138891     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002379     Document Type: Article

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