Reduction-responsive polypeptide nanogel delivers antitumor drug for improved efficacy and safety

Acta Biomaterialia

Volumn 27, Issue , 2015, Pages 179-193

  Huang, Kexin ^a   Shi, Bo ^a   Xu, Weiguo ^b   Ding, Jianxun ^b   Yang, Yu ^a   Liu, Haiyan ^a   Zhuang, Xiuli ^b   Chen, Xuesi ^b  

^a JILIN UNIVERSITY   (China)

^b CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

Author keywords

Chemotherapy efficacy; Controlled release; Polypeptide nanogel; Reduction responsiveness; Security

Indexed keywords

CARDIOVASCULAR SYSTEM; CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; DRUG PRODUCTS; HISTOLOGY; TARGETED DRUG DELIVERY; TUMORS;

% REDUCTIONS; ANTITUMOR DRUGS; CHEMOTHERAPY EFFICACY; CONTROLLED RELEASE; DOXORUBICIN; INTRACELLULAR DELIVERY; NANOGELS; POLYPEPTIDE NANOGEL; REDUCTION-RESPONSIVENESS; SECURITY;

NANOSTRUCTURED MATERIALS;

DOXORUBICIN; NANOPARTICLE; POLYPEPTIDE; REDUCTION RESPONSIVE POLYPEPTIDE NANOGEL; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; DELAYED RELEASE FORMULATION; GEL; NANOCAPSULE; PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; BONE MARROW CELL; CANCER INHIBITION; CELL PROLIFERATION; COMPARATIVE STUDY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG SYNTHESIS; HEPG2 CELL LINE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VIVO STUDY; LEUKOCYTE; LIVER CELL CARCINOMA; MALE; MICRONUCLEUS; MOUSE; NANOENCAPSULATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; TUMOR VOLUME; UPREGULATION; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; ANIMAL; APOPTOSIS; C57BL MOUSE; CELL SURVIVAL; CHEMISTRY; DELAYED RELEASE FORMULATION; DIFFUSION; DRUG EFFECTS; DRUG POTENTIATION; GEL; NEOPLASMS, EXPERIMENTAL; NUDE MOUSE; OXIDATION REDUCTION REACTION; PATHOLOGY; SYNTHESIS; TREATMENT OUTCOME;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DIFFUSION; DOXORUBICIN; DRUG SYNERGISM; GELS; HEP G2 CELLS; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; NANOCAPSULES; NEOPLASMS, EXPERIMENTAL; OXIDATION-REDUCTION; PEPTIDES; TREATMENT OUTCOME;

EID: 84944274478     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.08.049     Document Type: Article

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