The presence of Merkel cell polyomavirus is associated with deregulated expression of BRAF and Bcl-2 genes in non-small cell lung cancer

International Journal of Cancer

Volumn 133, Issue 3, 2013, Pages 604-611

  Lasithiotaki, I ^a   Antoniou, K M ^a   Derdas, S P ^a   Sarchianaki, E ^a   Symvoulakis, E K ^a   Psaraki, A ^a   Spandidos, D A ^a   Stathopoulos, E N ^a   Siafakas, N M ^a   Sourvinos, G ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

Bcl 2; BRAF; Merkel cell polyomavirus; non small cell lung cancer

Indexed keywords

B RAF KINASE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PROTEIN; PROTEIN BAK; PROTEIN BCL 2; PROTEIN P53; RB1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BAX GENE; BRAF GENE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; GENE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MERKEL CELL POLYOMAVIRUS; ONCOGENE K RAS; P53 GENE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTO ONCOGENE; RB1 GENE; REAL TIME POLYMERASE CHAIN REACTION; RKIP GENE;

AGED; CARCINOMA, NON-SMALL-CELL LUNG; DNA, VIRAL; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MERKEL CELL POLYOMAVIRUS; MIDDLE AGED; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; POLYOMAVIRUS INFECTIONS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-BCL-2; RAS PROTEINS; RNA, MESSENGER; SMOKING; TUMOR SUPPRESSOR PROTEIN P53; TUMOR VIRUS INFECTIONS;

EID: 84878019864     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28062     Document Type: Article

References (40)

1. Ferlay J, Shin HR, Bray F, et al. Cancer incidence and mortality worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer, 2010.
2. Alberg AJ, Ford FG, Samet JM,. Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest 2007; 132: 29S-55S.
3. Lee JM, Yanagawa J, Peebles KA, et al. Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment. Crit Rev Oncol Hematol 2008; 66: 208-17.
4. zur Hausen H,. Novel human polyomaviruses-re-emergence of a well known virus family as possible human carcinogens. Int J Cancer 2008; 123: 247-50.
5. Gjoerup O, Chang Y,. Update on human polyomaviruses and cancer. Adv Cancer Res 2010; 106: 1-51.
6. Feng H, Shuda M, Chang Y, et al. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008; 319: 1096-100.
7. Helmbold P, Lahtz C, Herpel E, et al. Frequent hypermethylation of RASSF1A tumour suppressor gene promoter and presence of Merkel cell polyomavirus in small cell lung cancer. Eur J Cancer 2009; 45: 2207-11.
8. Gheit T, Munoz JP, Levican J, et al. Merkel cell polyomavirus in non-small cell lung carcinomas from Chile. Exp Mol Pathol 2012; 93: 162-6.
9. Joh J, Jenson AB, Moore GD, et al. Human papillomavirus (HPV) and Merkel cell polyomavirus (MCPyV) in non small cell lung cancer. Exp Mol Pathol 2010; 89: 222-6.
10. Houben R, Schrama D, Becker JC,. Molecular pathogenesis of Merkel cell carcinoma. Exp Dermatol 2009; 18: 193-8.
11. Demetriou SK, Ona-Vu K, Sullivan EM, et al. Defective DNA repair and cell cycle arrest in cells expressing Merkel cell polyomavirus T antigen. Int J Cancer 2012; 131: 1818-27.
12. Houben R, Adam C, Baeurle A, et al. An intact retinoblastoma protein-binding site in Merkel cell polyomavirus large T antigen is required for promoting growth of Merkel cell carcinoma cells. Int J Cancer 2012; 130: 847-56.
13. Herbst RS, Heymach JV, Lippman SM,. Lung cancer. N Engl J Med 2008; 359: 1367-80.
14. Paik PK, Arcila ME, Fara M, et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J Clin Oncol 2011; 29: 2046-51.
15. Xu H, Wang X, Shen W, et al. [The expression and significance of RKIP in lung squamous cell carcinoma tissues]. Zhongguo Fei Ai Za Zhi 2011; 14: 194-8.
16. Huerta-Yepez S, Yoon NK, Hernandez-Cueto A, et al. Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival. BMC Cancer 2011; 11: 259.
17. Amundson SA, Myyers TG, Fornace AJ, Jr,. Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 1998; 17: 3287-99.
18. Brambilla E, Negoescu A, Gazzeri S, et al. Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors. Am J Pathol 1996; 149: 1941-52.
19. Fong KM, Sekido Y, Minna JD,. Molecular pathogenesis of lung cancer. J Thorac Cardiovasc Surg 1999; 118: 1136-52.
20. Andres C, Belloni B, Puchta U, et al. Prevalence of MCPyV in Merkel cell carcinoma and non-MCC tumors. J Cutan Pathol 2010; 37: 28-34.
21. Antoniou KM, Soufla G, Lymbouridou R, et al. Expression analysis of angiogenic growth factors and biological axis CXCL12/CXCR4 axis in idiopathic pulmonary fibrosis. Connect Tissue Res 2010; 51: 71-80.
22. Parkin DM,. The global health burden of infection-associated cancers in the year 2002. Int J Cancer 2006; 118: 3030-44.
23. Bouvard V, Baan R, Straif K, et al. A review of human carcinogens-Part B: biological agents. Lancet Oncol 2009; 10: 321-2.
24. Brentnall TA, Chen R, Lee JG, et al. Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis. Cancer Res 1995; 55: 4264-7.
25. Loyo M, Guerrero-Preston R, Brait M, et al. Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission. Int J Cancer 2010; 126: 2991-6.
26. Blasco RB, Francoz S, Santamaria D, et al. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell 2011; 19: 652-63.
27. Kobayashi M, Sonobe M, Takahashi T, et al. Clinical significance of BRAF gene mutations in patients with non-small cell lung cancer. Anticancer Res 2011; 31: 4619-23.
28. Moens U, Johannessen M,. Human polyomaviruses and cancer: expanding repertoire. J Dtsch Dermatol Ges 2008; 6: 704-8.
29. Dilworth SM,. Polyoma virus middle T antigen and its role in identifying cancer-related molecules. Nat Rev Cancer 2002; 2: 951-6.
30. Porebska I, Wyrodek E, Kosacka M, et al. Apoptotic markers p53, Bcl-2 and Bax in primary lung cancer. In Vivo 2006; 20: 599-604.
31. Sariyer IK, Merabova N, Patel PK, et al. Bag3-induced autophagy is associated with degradation of JCV oncoprotein, T-Ag. PLoS One 2012; 7: e45000.
32. Sahi H, Koljonen V, Kavola H, et al. Bcl-2 expression indicates better prognosis of Merkel cell carcinoma regardless of the presence of Merkel cell polyomavirus. Virchows Arch 2012; 461: 553-9.
33. Bhatia K, Goedert JJ, Modali R, et al. Merkel cell carcinoma subgroups by Merkel cell polyomavirus DNA relative abundance and oncogene expression. Int J Cancer 2010; 126: 2240-6.
34. Waltari M, Sihto H, Kukko H, et al. Association of Merkel cell polyomavirus infection with tumor p53, KIT, stem cell factor, PDGFR-alpha and survival in Merkel cell carcinoma. Int J Cancer 2011; 129: 619-28.
35. Rodig SJ, Cheng J, Wardzala J, et al. Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest 2012; 122: 4645-53.
36. Houben R, Schrama D, Alb M, et al. Comparable expression and phosphorylation of the retinoblastoma protein in Merkel cell polyoma virus-positive and negative Merkel cell carcinoma. Int J Cancer 2010; 126: 796-8.
37. Wetzels CT, Hoefnagel JG, Bakkers JM, et al. Ultrastructural proof of polyomavirus in Merkel cell carcinoma tumour cells and its absence in small cell carcinoma of the lung. PLoS One 2009; 4: e4958.
38. Bergallo M, Costa C, Terlizzi ME, et al. Quantitative detection of the new polyomaviruses KI, WU and Merkel cell virus in transbronchial biopsies from lung transplant recipients. J Clin Pathol 2010; 63: 722-5.
39. Goh S, Lindau C, Tiveljung-Lindell A, et al. Merkel cell polyomavirus in respiratory tract secretions. Emerg Infect Dis 2009; 15: 489-91.
40. Smith CJ, Perfetti T, King JA,. Perspectives on pulmonary inflammation and lung cancer risk in cigarette smokers. Inhal Toxicol 2006; 18: 667-77.