LHRH-targeted nanogels as a delivery system for cisplatin to ovarian cancer

Molecular Pharmaceutics

Volumn 10, Issue 10, 2013, Pages 3913-3921

  Nukolova, Natalia V ^a,b,d   Oberoi, Hardeep S ^c   Zhao, Yi ^c   Chekhonin, Vladimir P ^b,d   Kabanov, Alexander V ^a,c,e   Bronich, Tatiana K ^c  

^a MOSCOW STATE UNIVERSITY   (Russian Federation)

^b Serbsky State Research Center of Forensic and Social Psychiatry   (Russian Federation)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

^e University of North Carolina   (United States)

Author keywords

Cisplatin; LHRH targeting; Nanogels; Ovarian cancer; Targeted drug delivery

Indexed keywords

CISPLATIN; GONADORELIN; GONADORELIN RECEPTOR; NANOCARRIER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; FEMALE; GEL; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NANOPHARMACEUTICS; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; DRUG DELIVERY SYSTEMS; FEMALE; FLOW CYTOMETRY; HUMANS; MICE, NUDE; MICROSCOPY, CONFOCAL; NANOPARTICLES; OVARIAN NEOPLASMS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE;

EID: 84888205008     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4003688     Document Type: Article

References (32)

1. Duncan, R. The dawning era of polymer therapeutics. Nat. Rev. Drug Discovery 2003, 2, 347-60.
2. Petros, R. A.; DeSimone, J. M. Strategies in the design of nanoparticles for therapeutic applications. Nat. Rev. Drug Discovery 2010, 9, 615-27.
3. Vicent, M. J.; Duncan, R. Polymer conjugates: nanosized medicines for treating cancer. Trends Biotechnol. 2006, 24, 39-47.
4. Moghimi, S. M.; Hunter, A. C.; Murray, J. C. Nanomedicine: current status and future prospects. FASEB J. 2005, 19, 311-30.
5. Torchilin, V. P. Multifunctional nanocarriers. Adv. Drug Delivery Rev. 2006, 58, 1532-55.
6. Maeda, H.; Wu, J.; Sawa, T.; Matsumura, Y.; Hori, K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J. Controlled Release 2000, 65, 271-84.
7. Davis, M. E.; Chen, Z. G.; Shin, D. M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discovery 2008, 7, 771-82.
8. Mohanty, C.; Das, M.; Kanwar, J. R.; Sahoo, S. K. Receptor mediated tumor targeting: an emerging approach for cancer therapy. Curr. Drug Delivery 2011, 8, 45-58.
9. Schally, A. V.; Arimura, A.; Kastin, A. J.; Matsuo, H.; Baba, Y.; Redding, T. W.; Nair, R. M.; Debeljuk, L.; White, W. F. Gonadotropinreleasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones. Science 1971, 173, 1036-8.
10. Nagy, A.; Schally, A. V. Targeting of cytotoxic luteinizing hormone-releasing hormone analogs to breast, ovarian, endometrial, and prostate cancers. Biol. Reprod. 2005, 73, 851-9.
11. Schally, A. V.; Nagy, A. Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors. Eur. J. Endocrinol. 1999, 141, 1-14.
12. Dharap, S. S.; Wang, Y.; Chandna, P.; Khandare, J. J.; Qiu, B.; Gunaseelan, S.; Sinko, P. J.; Stein, S.; Farmanfarmaian, A.; Minko, T. Tumor-specific targeting of an anticancer drug delivery system by LHRH peptide. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 12962-7.
13. Sundaram, S.; Trivedi, R.; Durairaj, C.; Ramesh, R.; Ambati, B. K.; Kompella, U. B. Targeted drug and gene delivery systems for lung cancer therapy. Clin. Cancer Res. 2009, 15, 7299-308.
14. Minko, T.; Patil, M. L.; Zhang, M.; Khandare, J. J.; Saad, M.; Chandna, P.; Taratula, O. LHRH-targeted nanoparticles for cancer therapeutics. Methods Mol. Biol. 2010, 624, 281-94.
15. Taheri, A.; Dinarvand, R.; Ahadi, F.; Khorramizadeh, M. R.; Atyabi, F. The in vivo antitumor activity of LHRH targeted methotrexate-human serum albumin nanoparticles in 4T1 tumorbearing Balb/c mice. Int. J. Pharmaceutics 2012, 431, 183-9.
16. Saad, M.; Garbuzenko, O. B.; Ber, E.; Chandna, P.; Khandare, J. J.; Pozharov, V. P.; Minko, T. Receptor targeted polymers, dendrimers, liposomes: which nanocarrier is the most efficient for tumor-specific treatment and imaging? J. Controlled Release 2008, 130, 107-14.
17. Bronich, T. K.; Keifer, P. A.; Shlyakhtenko, L. S.; Kabanov, A. V. Polymer micelle with cross-linked ionic core. J. Am. Chem. Soc. 2005, 127, 8236-7.
18. Kim, J. O.; Nukolova, N. V.; Oberoi, H. S.; Kabanov, A. V.; Bronich, T. K. Block Ionomer Complex Micelles with Cross-Linked Cores for Drug Delivery. Polym. Sci., Ser. A: Chem. Phys. 2009, 51, 708-718.
19. Nukolova, N. V.; Oberoi, H. S.; Cohen, S. M.; Kabanov, A. V.; Bronich, T. K. Folate-decorated nanogels for targeted therapy of ovarian cancer. Biomaterials 2011, 32, 5417-26.
20. Oberoi, H. S.; Nukolova, N. V.; Zhao, Y.; Cohen, S. M.; Kabanov, A. V.; Bronich, T. K. Preparation and In Vivo Evaluation of Dichloro(1, 2-Diaminocyclohexane)platinum(II)-Loaded Core Cross-Linked Polymer Micelles. Chemother. Res. Pract. 2012, 2012, 905796.
21. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55-63.
22. Oberoi, H. S.; Laquer, F. C.; Marky, L. A.; Kabanov, A. V.; Bronich, T. K. Core cross-linked block ionomer micelles as pHresponsive carriers for cis-diamminedichloroplatinum(II). J. Controlled Release 2011, 153, 64-72.
23. Chacko, R. T.; Ventura, J.; Zhuang, J.; Thayumanavan, S. Polymer nanogels: A versatile nanoscopic drug delivery platform. Adv. Drug Delivery Rev. 2012, 64, 836-851.
24. Taratula, O.; Garbuzenko, O. B.; Kirkpatrick, P.; Pandya, I.; Savla, R.; Pozharov, V. P.; He, H.; Minko, T. Surface-engineered targeted PPI dendrimer for efficient intracellular and intratumoral siRNA delivery. J. Controlled Release 2009, 140, 284-93.
25. Oberoi, H. S.; Nukolova, N. V.; Laquer, F. C.; Poluektova, L. Y.; Huang, J.; Alnouti, Y.; Yokohira, M.; Arnold, L. L.; Kabanov, A. V.; Cohen, S. M.; Bronich, T. K. Cisplatin-loaded core cross-linked micelles: comparative pharmacokinetics, antitumor activity, and toxicity in mice. Int. J. Nanomed. 2012, 7, 2557-71.
26. Kim, J. O.; Kabanov, A. V.; Bronich, T. K. Polymer micelles with cross-linked polyanion core for delivery of a cationic drug doxorubicin. J. Controlled Release 2009, 138, 197-204.
27. Todd, R. C.; Lovejoy, K. S.; Lippard, S. J. Understanding the effect of carbonate ion on cisplatin binding to DNA. J. Am. Chem. Soc. 2007, 129, 6370-1.
28. Segal, E.; Le Pecq, J. B. Role of ligand exchange processes in the reaction kinetics of the antitumor drug cis-diamminedichloroplatinum-(II) with its targets. Cancer Res. 1985, 45, 492-8.
29. Low, P. S.; Henne, W. A.; Doorneweerd, D. D. Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc. Chem. Res. 2008, 41, 120-9.
30. Arany, I.; Safirstein, R. L. Cisplatin nephrotoxicity. Semin. Nephrol. 2003, 23, 460-464.
31. Uchino, H.; Matsumura, Y.; Negishi, T.; Koizumi, F.; Hayashi, T.; Honda, T.; Nishiyama, N.; Kataoka, K.; Naito, S.; Kakizoe, T. Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats. Br. J. Cancer 2005, 93, 678-87.
32. Newman, M. S.; Colbern, G. T.; Working, P. K.; Engbers, C.; Amantea, M. A. Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in longcirculating, pegylated liposomes (SPI-077) in tumor-bearing mice. Cancer Chemother. Pharmacol. 1999, 43, 1-7.