Development of chitosan nanoparticles as drug delivery system for a prototype capsid inhibitor

International Journal of Pharmaceutics

Volumn 495, Issue 2, 2015, Pages 771-782

  Xue, Meiyan ^a,b,c   Hu, Steven ^b   Lu, Yifei ^a   Zhang, Yu ^a   Jiang, Xutao ^a   An, Sai ^a   Guo, Yubo ^a   Zhou, Xue ^b   Hou, Huimin ^c   Jiang, Chen ^a  

^a FUDAN UNIVERSITY   (China)

^b Roche Innovation Center Shanghai   (China)

^c SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY   (China)

Author keywords

Bay41 4109; Cationic nanoparticles; Central composite factorial design; Chitosan; Drug encapsulation; Hepatitis B virus (HBV)

Indexed keywords

ANTIVIRUS AGENT; BAY 414109; CHITOSAN NANOPARTICLE; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG; BAY 41-4109; CHITOSAN; CROSS LINKING REAGENT; DRUG CARRIER; NANOPARTICLE; POLYPHOSPHATE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIPHOSPHORIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY ASSAY; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG SOLUBILITY; GELATION; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; LIVER MICROSOME; MALE; MICROSOME; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; VIRUS CAPSID; VIRUS REPLICATION; X RAY DIFFRACTION; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECTS; MEDICINAL CHEMISTRY; MOUSE; ORAL DRUG ADMINISTRATION; PROCEDURES; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CAPSID; CELL LINE; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; CROSS-LINKING REAGENTS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; MALE; MICE; NANOPARTICLES; POLYPHOSPHATES; PYRIDINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84944271551     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.08.056     Document Type: Article

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