Manipulation of tumor metabolism for therapeutic approaches: ovarian cancer-derived cell lines as a model system

Cellular Oncology

Volumn 38, Issue 5, 2015, Pages 377-385

  Goetze, Kristina ^a   Fabian, Christian G ^a   Siebers, Andrea ^a   Binz, Livia ^a   Faber, Daniel ^a   Indraccolo, Stefano ^b   Nardo, Giorgia ^b   Sattler, Ulrike G A ^a   Mueller Klieser, Wolfgang ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b VENETO INSTITUTE OF ONCOLOGY IOV IRCCS   (Italy)

Author keywords

imBI; Metabolic inhibitors; Ovarian cancer; Radiation therapy; Tumor metabolism

Indexed keywords

CARBONATE DEHYDRATASE IX; DEOXYGLUCOSE; GLUCOSE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUCOSE TRANSPORTER 1; LACTATE DEHYDROGENASE; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 4; OXYGEN; REACTIVE OXYGEN METABOLITE; ROTENONE; ADENOSINE TRIPHOSPHATE; OXAMIC ACID;

ARTICLE; BIOLUMINESCENCE; CARCINOGENESIS; CELL METABOLISM; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXIC CONCENTRATION; DOUBLE STRANDED DNA BREAK; ENERGY METABOLISM; FEMALE; GAMMA IRRADIATION; GAMMA RADIATION; GLYCOLYSIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; IRRADIATION; METABOLIC INHIBITION; OVARIAN CANCER CELL LINE; OVARY CANCER; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIVITY; RESPIRATORY CHAIN; TREATMENT RESPONSE; TUMOR VOLUME; TUMOR XENOGRAFT; ANIMAL; CELL SURVIVAL; CHEMORADIOTHERAPY; DNA DAMAGE; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; OVARIAN NEOPLASMS; PROCEDURES; RADIATION RESPONSE; SCID MOUSE; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; CHEMORADIOTHERAPY; DEOXYGLUCOSE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GAMMA RAYS; GLUCOSE; GLYCOLYSIS; HUMANS; MICE, SCID; MICROSCOPY, FLUORESCENCE; OVARIAN NEOPLASMS; OXAMIC ACID; OXYGEN CONSUMPTION; REACTIVE OXYGEN SPECIES; ROTENONE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84944160963     PISSN: 22113428     EISSN: 22113436     Source Type: Journal    
DOI: 10.1007/s13402-015-0237-5     Document Type: Article

References (28)

1. A. Geurts van Kessel, The cancer genome: from structure to function. Cell. Oncol. 37, 155–165 (2014)
2. O. Warburg, On the origin of cancer cells. Science 123, 309–314 (1956)
3. J.P. Bayley, P. Devilee, The Warburg effect in 2012. Curr. Opin. Oncol. 24, 62–67 (2012)
4. V. Gogvadze, B. Zhivotovsky, S. Orrenius, The Warburg effect and mitochondrial stability in cancer cells. Mol. Asp. Med. 31, 60–74 (2010)
5. W.H. Koppenol, P.L. Bounds, C.V. Dang, Otto Warburg’s contributions to current concepts of cancer metabolism. Nat. Rev. Cancer 11, 325–337 (2011)
6. A. Herling, M. Konig, S. Bulik, H.G. Holzhutter, Enzymatic features of the glucose metabolism in tumor cells. FEBS J. 278, 2436–2459 (2011)
7. H.R. Oh, C.H. An, N.J. Yoo, S.H. Lee, Somatic mutations of amino acid metabolism-related genes in gastric and colorectal cancers and their regional heterogeneity—a short report. Cell. Oncol. 37, 455–461 (2014)
8. D.M. Brizel, T. Schroeder, R.L. Scher, S. Walenta, R.W. Clough, M.W. Dewhirst, W. Mueller-Klieser, Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 51, 349–353 (2001)
9. S. Walenta, M. Wetterling, M. Lehrke, G. Schwickert, K. Sundfor, E.K. Rofstad, W. Mueller-Klieser, High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res. 60, 916–921 (2000)
10. V. Quennet, A. Yaromina, D. Zips, A. Rosner, S. Walenta, M. Baumann, W. Mueller-Klieser, Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice. Radiother. Oncol. 81, 130–135 (2006)
11. U.G. Sattler, S.S. Meyer, V. Quennet, C. Hoerner, H. Knoerzer, C. Fabian, A. Yaromina, D. Zips, S. Walenta, M. Baumann, W. Mueller-Klieser, Glycolytic metabolism and tumour response to fractionated irradiation. Radiother. Oncol. 94, 102–109 (2010)
12. F. Hirschhaeuser, U.G. Sattler, W. Mueller-Klieser, Lactate: a metabolic key player in cancer. Cancer Res. 71, 6921–6925 (2011)
13. U.G. Sattler, W. Mueller-Klieser, The anti-oxidant capacity of tumour glycolysis. Int. J. Radiat. Biol. 85, 963–971 (2009)
14. U.G. Sattler, F. Hirschhaeuser, W.F. Mueller-Klieser, Manipulation of glycolysis in malignant tumors: fantasy or therapy? Curr. Med. Chem. 17, 96–108 (2010)
15. C. Fabian, L. Koetz, E. Favaro, S. Indraccolo, W. Mueller-Klieser, U.G. Sattler, Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts. FEBS J. 279, 882–891 (2012)
16. J. Benard, S.J. Da, M.C. De Blois, P. Boyer, P. Duvillard, E. Chiric, G. Riou, Characterization of a human ovarian adenocarcinoma line, IGROV1, in tissue culture and in nude mice. Cancer Res. 45, 4970–4979 (1985)
17. A. Alama, F. Barbieri, A. Favre, M. Cagnoli, E. Noviello, F. Pedulla, M. Viale, G. Foglia, N. Ragni, Establishment and characterization of three new cell lines derived from the ascites of human ovarian carcinomas. Gynecol. Oncol. 62, 82–88 (1996)
18. E. Favaro, G. Nardo, L. Persano, M. Masiero, L. Moserle, R. Zamarchi, E. Rossi, G. Esposito, M. Plebani, U. Sattler, T. Mann, W. Mueller-Klieser, V. Ciminale, A. Amadori, S. Indraccolo, Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death. Am. J. Pathol. 173, 1186–1201 (2008)
19. S. Domcke, R. Sinha, D.A. Levine, C. Sander, N. Schultz, Evaluating cell lines as tumour models by comparison of genomic profiles. Nat. Commun. 4, 2126 (2013)
20. C.J. Lord, A. Ashworth, Mechanisms of resistance to therapies targeting BRCA-mutant cancers. Nat. Med. 19, 1381–1388 (2013)
21. C. Arienti, A. Tesei, S. Carloni, P. Ulivi, A. Romeo, G. Ghigi, E. Menghi, A. Sarnelli, E. Parisi, R. Silvestrini, W. Zoli, SLUG silencing increases radiosensitivity of melanoma cells in vitro. Cell. Oncol. 36, 131–139 (2013)
22. Y. Zhou, E.O. Hileman, W. Plunkett, M.J. Keating, P. Huang, Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. Blood 101, 4098–4104 (2003)
23. J.P. Fruehauf, F.L. Meyskens Jr., Reactive oxygen species: a breath of life or death? Clin. Cancer Res. 13, 789–794 (2007)
24. M.A. Fath, A.R. Diers, N. ykin-Burns, A.L. Simons, L. Hua, D.R. Spitz, Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. Cancer Biol. Ther. 8, 1228–1236 (2009)
25. N. Li, K. Ragheb, G. Lawler, J. Sturgis, B. Rajwa, J.A. Melendez, J.P. Robinson, Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J. Biol. Chem. 278, 8516–8525 (2003)
26. H. Pelicano, L. Feng, Y. Zhou, J.S. Carew, E.O. Hileman, W. Plunkett, M.J. Keating, P. Huang, Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J. Biol. Chem. 278, 37832–37839 (2003)
27. Y. Zhao, H. Liu, Z. Liu, Y. Ding, S.P. Ledoux, G.L. Wilson, R. Voellmy, Y. Lin, W. Lin, R. Nahta, B. Liu, O. Fodstad, J. Chen, Y. Wu, J.E. Price, M. Tan, Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism. Cancer Res. 71, 4585–4597 (2011)
28. D.A. Tennant, R.V. Duran, E. Gottlieb, Targeting metabolic transformation for cancer therapy. Nat. Rev. Cancer 10, 267–277 (2010)