Polyunsaturated fatty acids trigger apoptosis of colon cancer cells through a mitochondrial pathway

Archives of Medical Science

Volumn 11, Issue 5, 2015, Pages 1081-1094

  Zhang, Chengcheng ^a   Yu, Haining ^b   Shen, Yuzhen ^a   Ni, Xiaofeng ^a   Shen, Shengrong ^a   Das, Undurti N ^c,d  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^c UND Life Sciences   (United States)

^d GAYATRI VIDYA PARISHAD COLLEGE OF ENGINEERING   (India)

Author keywords

Apoptosis; ATP; Caspases; Colon cancer; Lipid droplets; Mitochondrial pathway; Polyunsaturated fatty acids

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARACHIDONIC ACID; CALCIUM ION; CASPASE 3; CASPASE 9; DOCOSAHEXAENOIC ACID; FAT DROPLET; FLUOROURACIL; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; LINOLEIC ACID; LINOLENIC ACID; LIPID PEROXIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; COLON CANCER; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; LOVO CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PROTEIN EXPRESSION; RKO CELL LINE;

EID: 84944068087     PISSN: 17341922     EISSN: 18969151     Source Type: Journal    
DOI: 10.5114/aoms.2015.54865     Document Type: Article

References (37)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin 2005; 55: 74-108.
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90.
3. Granci V, Cai F, Lecumberri E, Clerc A, Dupertuis YM, Pichard C. Colon cancer cell chemosensitisation by fish oil emulsion involves apoptotic mitochondria pathway. Br J Nutr 2013; 109: 1188-95.
4. Yashodhara BM, Umakanth S, Pappachan JM, Bhat SK, Kamath R, Choo BH. Omega-3 fatty acids: A comprehensive review of their role in health and disease. Postgrad Med J 2009; 85: 84-90.
5. Hofmanova J, Ciganek M, Slavik J, et al. Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids. J Nutr Biochem 2012; 23: 539-48.
6. Fahy B, Bold RJ. Epidemiology and molecular genetics of colorectal cancer. Surg Oncol 1998; 7: 115-23.
7. Fasano E, Serini S, Piccioni E, et al. DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochim Biophys Acta 2012; 1822: 1762-72.
8. Xia LJ, Li MG. Effect of n-3 polyunsaturated fatty acids on proliferation and apoptosis of human colon cancer cell. Zhonghua Wei Chang Wai Ke Za Zhi 2012; 15: 490-4.
9. Bathen TF, Holmgren K, Lundemo AG, et al. Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice. Anticancer Res 2008; 28: 3717-23.
10. Kuan CY, Walker TH, Luo PG, Chen CF. Long-chain polyunsaturated fatty acids promote paclitaxel cytotoxicity via inhibition of the MDR1 gene in the human colon cancer Caco-2 cell line. J Am Coll Nutr 2011; 30: 265-73.
11. Wong RS. Apoptosis in cancer: From pathogenesis to treatment. J Exp Clin Cancer Res 2011; 30: 87.
12. Basile V, Belluti S, Ferrari E, et al. bis-Dehydroxy-curcumin triggers mitochondrial-associated cell death in human colon cancer cells through ER-stress induced autophagy. PLoS One 2013; 8: E53664.
13. Lu X, Yu H, Ma Q, Shen S, Das UN. Linoleic acid suppresses colorectal cancer cell growth by inducing oxidant stress and mitochondrial dysfunction. Lipids Health Dis 2010; 9: 106.
14. Yang J, Yu H, Sun S, et al. Mechanism of free Zn(2+) enhancing inhibitory effects of EGCG on the growth of PC-3 cells: Interactions with mitochondria. Biol Trace Elem Res 2009; 131: 298-310.
15. Dai J, Shen J, Pan W, Shen S, Das UN. Effects of polyunsaturated fatty acids on the growth of gastric cancer cells in vitro. Lipids Health Dis 2013; 12: 71.
16. Wang H, Joseph JA. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 1999; 27: 612-6.
17. Yin H, Guo C, Wang Y, et al. Fengycin inhibits the growth of the human lung cancer cell line 95D through reactive oxygen species production and mitochondria-dependent apoptosis. Anticancer Drugs 2013; 24: 587-98.
18. Yu HN, Zhang LC, Yang JG, Das UN, Shen SR. Effect of laminin tyrosine-isoleucine-glycine-serine-arginine peptide on the growth of human prostate cancer (PC-3) cells in vitro. Eur J Pharmacol 2009; 616: 251-5.
19. Javadov S, Karmazyn M. Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection. Cell Physiol Biochem 2007; 20: 1-22.
20. Armstrong JS. The role of the mitochondrial permeability transition in cell death. Mitochondrion 2006; 6: 225-34.
21. Yang HL, Chen CS, Chang WH, et al. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Lett 2006; 231: 215-27.
22. Begin ME, Das UN, Ells G, Horrobin DF. Selective killing of tumor cells by polyunsaturated fatty acids. Prostaglandins Leukotrienes Med 1985; 19: 177-86.
23. Begin ME, Ells G, Das UN, Horrobin DF. Differential killing of human carcinoma cells supplemented with n-3 and n-6 polyunsaturated fatty acids. J Natl Cancer Inst 1986; 77: 1053-62.
24. Begin ME, Das UN, Ells G. Cytotoxic effects of essential fatty acids (EFA) in mixed cultures of normal and malignant human cells. Prog Lipid Res 1986; 25: 573-5.
25. Geelen A, Schouten JM, Kamphuis C, et al. Fish consumption, n-3 fatty acids, and colorectal cancer: A meta-analysis of prospective cohort studies. Am J Epidemiol 2007; 166: 1116-25.
26. Kroemer G. The mitochondrial permeability transition pore complex as a pharmacological target. An introduction. Curr Med Chem 2003; 10: 1469-72.
27. Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 2001; 8: 613-21.
28. Zou X, Liu SL, Zhou JY, Wu J, Ling BF, Wang RP. Beta-asarone induces LoVo colon cancer cell apoptosis by up-regulation of caspases through a mitochondrial pathway in vitro and in vivo. Asian Pac J Cancer Prev 2012; 13: 5291-8.
29. Gogvadze V, Orrenius S, Zhivotovsky B. Mitochondria as targets for cancer chemotherapy. Semin Cancer Biol 2009; 19: 57-66.
30. Sangeetha PS, Das UN. Gamma-linolenic acid and eicosapentaenoic acid potentiate the cytotoxicity of anti-cancer drugs on human cervical carcinoma (HeLa) cells in vitro. Med Sci Res 1993; 21: 457-9.
31. Madhavi N, Das UN. Effect of n-6 and n-3 fatty acids on the survival of vincristine sensitive and resistant human cervical carcinoma cells in vitro. Cancer Lett 1994; 84: 31-41.
32. Madhavi N, Das UN. Reversal of KB-3-1 and KB-Ch-8-5 tumor cell drug-resistance by cis-unsaturated fatty acids in vitro. Med Sci Res 1994; 22: 689-92.
33. Das UN, Madhavi N, Padma M, Sagar PS. Can tumor cell drug-resistance be reversed by essential fatty acids and their metabolites? Prostaglandins Leukot Essen Fatty Acids 1998; 58: 39-54.
34. Kong X, Ge H, Chen L, et al. Gamma-linolenic acid modulates the response of multidrug-resistant K562 leukemic cells to anticancer drugs. Toxicol In Vitro 2009; 23: 634-9.
35. Mackie SJ, Sharma DM, Cooper AJ, Harris NM, Lwaleed BA. Meglumine eicosapentaenoic acid (MeEPA) a new soluble omega-3 fatty acid formulation: In vitro bladder cancer cytotoxicity tests in combination with epirubicin and mitomycin. Prostaglandins Leukot Essent Fatty Acids 2006; 75: 367-73.
36. Das UN, Madhavi N. Effect of polyunsaturated fatty acids on drug-sensitive and resistant tumor cells in vitro. Lipids Health Dis 2011; 10: 159.
37. Cicero AFG, Reggi A, Parini A, Borghi C. Application of polyunsaturated fatty acids in internal medicine: Beyond the established cardiovascular effects. Arch Med Sci 2012; 5: 784-93.