Effects of the main active components combinations of Astragalus and Panax notoginseng on energy metabolism in brain tissues after cerebral ischemia-reperfusion in mice

Pharmacognosy Magazine

Volumn 11, Issue 44, 2015, Pages 732-739

  Huang, Xiao Ping ^a,b,c   Ding, Huang ^c   Wang, Bei ^b   Qiu, Yong Yuan ^b   Tang, Ying Hong ^c   Zeng, Rong ^b   Deng, Chang Qing ^a,b,c  

^a HUNAN UNIVERSITY OF CHINESE MEDICINE   (China)

^b Key Lab of Hunan Prov for Prev and Treatm of Intgd Traditional Chinese and W Med on Cardio Cerebr Dis   (China)

^c HUNAN UNIVERSITY   (China)

Author keywords

Active components combinations; AMP activated protein kinase; Astragalus and Panax notoginseng; cerebral ischemia; energy metabolism; glucose transporter 3

Indexed keywords

ADENINE NUCLEOTIDE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ASTRAGALOSIDE IV; GINSENOSIDE RB 1; GINSENOSIDE RG 1; GLUCOSE TRANSPORTER 3; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NOTOGINSENOSIDE R1; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTRAGALUS (PLANT); BRAIN ISCHEMIA; BRAIN TISSUE; CONTROLLED STUDY; ENERGY METABOLISM; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PANAX NOTOGINSENG; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

EID: 84944060770     PISSN: 09731296     EISSN: 09764062     Source Type: Journal    
DOI: 10.4103/0973-1296.165572     Document Type: Article

References (23)

1. Huang XP, Tan H, Chen BY, Deng CQ. Astragalus extract alleviates nerve injury after cerebral ischemia by improving energy metabolism and inhibiting apoptosis. Biol Pharm Bull 2012;35:449-54.
2. Li H, Deng CQ, Chen BY, Zhang SP, Liang Y, Luo XG. Total saponins of Panax notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion. J Ethnopharmacol 2009;121:412-8.
3. Huang X, Tan H, Chen B, Deng C. Influence of astragalosides and Panax notoginseng saponins compatibility on MMP-9 and TIMP-1 after cerebral ischemia-reperfusion in mice. Zhongguo Zhong Yao Za Zhi 2010;35:2187-91.
4. Tan H, Huang XP, Deng CQ. Effects of astragaloside and Panax notoginseng saponins combination on oxidative stress of cerebral ischemic reperfusion injury in mice. Zhong Xi Yi Jie He Xue Bao 2010;8:448-52.
5. Huang XP, Qiu YY, Wang B, Ding H, Tang YH, Zeng R, et al. Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice. Pharmacogn Mag 2014;10:402-9.
6. Arumugam S, Thandavarayan RA, Veeraveedu PT, Giridharan VV, Soetikno V, Harima M, et al. Involvement of AMPK and MAPK signaling during the progression of experimental autoimmune myocarditis in rats and its blockade using a novel antioxidant. Exp Mol Pathol 2012;93:183-9.
7. Yonekura I, Kawahara N, Nakatomi H, Furuya K, Kirino T. A model of global cerebral ischemia in C57 BL/6 mice. J Cereb Blood Flow Metab 2004;24:151-8.
8. Zhan C, Yang J, Zhan L. RP-HPLC determination of effects of isoliquiritigenin on brain energy metabolism in repeated cerebral ischemia-reperfusion mice. Chin J Pharm Anal 2005;25:639-42.
9. Manfredi G, Yang L, Gajewski CD, Mattiazzi M. Measurements of ATP in mammalian cells. Methods 2002;26:317-26.
10. McPhee SJ, Hammer GD. Pathophysiology of Disease: An Introduction to Clinical Medicine. 6th ed., Ch. 7. New York: McGraw-Hill Medical; 2009.
11. Lee EJ, Wu TS, Chang GL, Li CY, Chen TY, Lee MY, et al. Delayed treatment with nicotinamide inhibits brain energy depletion, improves cerebral microperfusion, reduces brain infarct volume, but does not alter neurobehavioral outcome following permanent focal cerebral ischemia in Sprague Dawley rats. Curr Neurovasc Res 2006;3:203-13.
12. Turnley AM, Stapleton D, Mann RJ, Witters LA, Kemp BE, Bartlett PF. Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system. J Neurochem 1999;72:1707-16.
13. Ramamurthy S, Ronnett GV. Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain. J Physiol 2006;574 (Pt 1):85-93.
14. Li J, McCullough LD. Effects of AMP-activated protein kinase in cerebral ischemia. J Cereb Blood Flow Metab 2010;30:480-92.
15. Ronnett GV, Ramamurthy S, Kleman AM, Landree LE, Aja S. AMPK in the brain: its roles in energy balance and neuroprotection. J Neurochem 2009;109 Suppl 1:17-23.
16. Shen L, Miao J, Yuan F, Zhao Y, Tang Y, Wang Y, et al. Overexpression of adiponectin promotes focal angiogenesis in the mouse brain following middle cerebral artery occlusion. Gene Ther 2013;20:93-101.
17. Almeida A, Moncada S, Bolaños JP. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol 2004;6:45-51.
18. Pellerin L. How astrocytes feed hungry neurons. Mol Neurobiol 2005;32:59-72.
19. Culmsee C, Monnig J, Kemp BE, Mattson MP. AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci 2001;17:45-58.
20. Blázquez C, Geelen MJ, Velasco G, Guzmán M. The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes. FEBS Lett 2001;489:149-53.
21. Iwabuchi S, Kawahara K. Inducible astrocytic glucose transporter-3 contributes to the enhanced storage of intracellular glycogen during reperfusion after ischemia. Neurochem Int 2011;59:319-25.
22. Simpson IA, Carruthers A, Vannucci SJ. Supply and demand in cerebral energy metabolism: the role of nutrient transporters. J Cereb Blood Flow Metab 2007;27:1766-91.
23. Cidad P, Almeida A, Bolaños JP. Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase. Biochem J 2004;384 (Pt 3):629-36.