Delayed treatment with nicotinamide inhibits brain energy depletion, improves cerebral microperfusion, reduces brain infarct volume, but does not alter neurobehavioral outcome following permanent focal cerebral ischemia in Sprague Dawley rats

Current Neurovascular Research

Volumn 3, Issue 3, 2006, Pages 203-213

  Lee, E Jian ^a,b   Wu, Tian Shung ^a,c   Chang, Guan Liang ^a   Li, Chia Ying ^a,c   Chen, Tsung Ying ^a   Lee, Ming Yang ^a,b   Chen, Hung Yi ^a,b   Maynard, Kenneth I ^d  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b TZU CHI UNIVERSITY   (Taiwan)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^d SANOFI   (France)

Author keywords

Brain energy metabolism; Middle cerebral artery occlusion; Neuroprotection; Niacinamide; Stroke; Vitamin B3

Indexed keywords

ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; NICOTINAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BIOENERGY; BODY WEIGHT; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN PROTECTION; BRAIN TEMPERATURE; CONTROLLED STUDY; CORE TEMPERATURE; DRUG INHIBITION; DRUG MECHANISM; ENERGY METABOLISM; HEMISPHERE; HISTOPATHOLOGY; HYPERTHERMIA; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROLOGIC EXAMINATION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RAT; RECTUM TEMPERATURE; SCORING SYSTEM; TEMPERATURE MEASUREMENT; THERAPY DELAY;

ADENINE; ADENOSINE TRIPHOSPHATE; ANIMALS; BEHAVIOR, ANIMAL; BRAIN; BRAIN CHEMISTRY; CEREBROVASCULAR CIRCULATION; DISEASE MODELS, ANIMAL; FEVER; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; NEUROPROTECTIVE AGENTS; NIACINAMIDE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; TIME FACTORS;

EID: 33746885193     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720206778018749     Document Type: Article

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