Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

Molecular Cancer

Volumn 14, Issue 1, 2015, Pages

  Yang, Ming Chen ^a   Wang, Hao Chen ^a   Hou, Ya Chin ^a,b   Tung, Hui Ling ^b   Chiu, Tai Jan ^c   Shan, Yan Shen ^a,b  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

ALDH1; Autophagy; Cancer stem cells; CD133; CD44; Gemcitabine; Osteopontin; Pancreatic cancer

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; AUTOPHAGY PROTEIN 5; BECLIN 1; CD133 ANTIGEN; CELL PROTEIN; CHLOROQUINE; GEMCITABINE; HERMES ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LC3 II PROTEIN; LC3 PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOPONTIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; DEOXYCYTIDINE;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ATG5 GENE; ATG7 GENE; AUTOPHAGY; BECN1 GENE; CANCER INHIBITION; CANCER PROGNOSIS; CANCER STEM CELL; CANCER SURVIVAL; CELL ACTIVITY; CELL POPULATION; CELL STRUCTURE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CORRELATIONAL STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; DOWN REGULATION; DRUG EFFICACY; DRUG SENSITIVITY; ENZYME ACTIVITY; FEMALE; FLOW CYTOMETRY; GENE; GENE SILENCING; HISTOCHEMISTRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE AGED; MOUSE; NONHUMAN; ONCOLOGICAL PARAMETERS; OVERALL SURVIVAL; PANCREAS CANCER; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SPHERE FORMATION; TISSUE MICROARRAY; TREATMENT DURATION; TUMOR VOLUME; TUMOR WEIGHT; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; DRUG EFFECTS; METABOLISM; PANCREAS TUMOR; TUMOR CELL CULTURE; TUMOR CELL LINE;

ANTIMETABOLITES, ANTINEOPLASTIC; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; DEOXYCYTIDINE; HUMANS; MALE; MIDDLE AGED; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84944037853     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/s12943-015-0449-3     Document Type: Article

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