TNF-alpha modulates adipose macrophage polarization to M1 phenotype in response to scorpion venom

Inflammation Research

Volumn 64, Issue 11, 2015, Pages 929-936

  Ait Lounis, Aouatef ^a   Laraba Djebari, Fatima ^a  

^a UNIVERSITY OF SCIENCES AND TECHNOLOGY HOUARI BOUMEDIENE   (Algeria)

Author keywords

Aah venom; Ftox G50 venom; IL12p40; IL23; NOSi; TNF antagonist

Indexed keywords

ARGINASE 1; ETANERCEPT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 12P40; INTERLEUKIN 23; MESSENGER RNA; SCORPION VENOM; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; NOS2 PROTEIN, MOUSE;

ADIPOSE TISSUE MACROPHAGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; ENVENOMATION; IMMUNE SYSTEM; IMMUNOMODULATION; IN VIVO STUDY; INFLAMMATION; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STROMA CELL; STROMAL VASCULAR CELL; UPREGULATION; ADIPOSE TISSUE; ANIMAL; ANTAGONISTS AND INHIBITORS; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION; GENETICS; IMMUNOLOGY; MALE; METABOLISM; PHENOTYPE;

ADIPOSE TISSUE; ANIMALS; CYTOKINES; ETANERCEPT; GENE EXPRESSION; MACROPHAGES; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE II; PHENOTYPE; RNA, MESSENGER; SCORPION VENOMS;

EID: 84944035411     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-015-0876-z     Document Type: Article

References (31)

1. Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity. 2010;32:593–604.
2. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007;447:1116–20.
3. Mantovani A, Schioppa T, Biswas SK, Marchesi F, Allavena P, Sica A. Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations. Tumori. 2003;89:459–68.
4. Bronte V, Zanovello P. Regulation of immune responses by l-arginine metabolism. Nat Rev Immunol. 2005;5:641–54.
5. Gordon S. Alternative activation of macrophages. Nat Rev Immunol. 2003;3:23–35.
6. Fialho EM, Maciel MC, Silva AC, et al. Immune cells recruitment and activation by Tityus serrulatus scorpion venom. Toxicon Off J Int Soc Toxinol. 2011;58:480–5.
7. Fukuhara YD, Reis ML, Dellalibera-Joviliano R, Cunha FQ, Donadi EA. Increased plasma levels of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha in patients moderately or severely envenomed by Tityus serrulatus scorpion sting. Toxicon Off J Int Soc on Toxinol. 2003;41:49–55.
8. Jalali A, Pipelzadeh MH, Taraz M, Khodadadi A, Makvandi M, Rowan EG. Serum TNF-alpha levels reflect the clinical severity of envenomation following a Hemiscorpius lepturus sting. Eur Cytokine Netw. 2011;22:5–10.
9. Petricevich VL. Balance between pro- and anti-inflammatory cytokines in mice treated with Centruroides noxius scorpion venom. Mediators Inflamm. 2006;2006:54273.
10. Ishizuka EK, Ferreira MJ, Grund LZ, et al. Role of interplay between IL-4 and IFN-gamma in the in regulating M1 macrophage polarization induced by Nattectin. Int Immunopharmacol. 2012;14:513–22.
11. Zoccal KF, Bitencourt Cda S, Secatto A, et al. Tityus serrulatus venom and toxins Ts1, Ts2 and Ts6 induce macrophage activation and production of immune mediators. Toxicon Off J Int Soc Toxinol. 2011;57:1101–8.
12. Zoccal KF, Bitencourt Cda S, Paula-Silva FW, et al. TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce macrophage-derived inflammatory mediators. PLoS One. 2014;9:e88174.
13. Adi-Bessalem S, Mendil A, Hammoudi-Triki D, Laraba-Djebari F. Lung immunoreactivity and airway inflammation: their assessment after scorpion envenomation. Inflammation. 2012;35:501–8.
14. Ait-Lounis A, Laraba-Djebari F. TNF-alpha involvement in insulin resistance induced by experimental scorpion envenomation. PLoS Negl Tropical Dis. 2012;6:e1740.
15. Raouraoua-Boukari R, Sami-Merah S, Hammoudi-Triki D, Martin-Eauclaire MF, Laraba-Djebari F. Immunomodulation of the inflammatory response induced by Androctonus australis hector neurotoxins: biomarker interactions. NeuroImmunoModul. 2012;19:103–10.
16. Laraba-Djebari F, Hammoudi D. Use of toxic fraction isolated from Algerian Androctonus australis hector scorpion venom for the assessment of anti-venom serum. Archives de l’Institut Pasteur d’Algerie Institut Pasteur d’Algerie. 1998;62:254–66.
17. Djeraba A, Kut E, Rasschaert D, Quere P. Antiviral and antitumoral effects of recombinant chicken myelomonocytic growth factor in virally induced lymphoma. Int Immunopharmacol. 2002;2:1557–66.
18. Cohen CR, Moscicki AB, Scott ME, et al. Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa. AIDS. 2010;24:2069–74.
19. de Boer JF, Dikkers A, Jurdzinski A, et al. Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice. PLoS One. 2014;9:e106300.
20. Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Investig. 2003;112:1821–30.
21. Caspar-Bauguil S, Cousin B, Galinier A, et al. Adipose tissues as an ancestral immune organ: site-specific change in obesity. FEBS Lett. 2005;579:3487–92.
22. Park HT, Lee ES, Cheon YP, et al. The relationship between fat depot-specific preadipocyte differentiation and metabolic syndrome in obese women. Clin Endocrinol. 2012;76:59–66.
23. Cohen CA, Shea AA, Heffron CL, Schmelz EM, Roberts PC. Intra-abdominal fat depots represent distinct immunomodulatory microenvironments: a murine model. PLoS One. 2013;8:e66477.
24. Hevener AL, Olefsky JM, Reichart D, et al. Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Investig. 2007;117:1658–69.
25. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Investig. 2007;117:175–84.
26. Krausgruber T, Blazek K, Smallie T, et al. IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol. 2011;12:231–8.
27. Hadaddezfuli R, Khodadadi A, Assarehzadegan MA, Pipelzadeh MH, Saadi S. Hemiscorpius lepturus venom induces expression and production of interleukin-12 in human monocytes. Toxicon Off J Int Soc Toxinol. 2015;100:27–31.
28. Bronte V, Kasic T, Gri G, et al. Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med. 2005;201:1257–68.
29. Palm NW, Medzhitov R. Role of the inflammasome in defense against venoms. Proc Natl Acad Sci USA. 2013;110:1809–14.
30. Lumeng CN, Deyoung SM, Saltiel AR. Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins. Am J physiol Endocrinol Metabol. 2007;292:E166–74.
31. Wang H, Peters T, Kess D, et al. Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation. J Clin Investig. 2006;116:2105–14.