Intra-Abdominal Fat Depots Represent Distinct Immunomodulatory Microenvironments: A Murine Model

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Cohen, Courtney A ^a   Shea, Amanda A ^a   Heffron, C Lynn ^a   Schmelz, Eva M ^a   Roberts, Paul C ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; C REACTIVE PROTEIN; CXCL1 CHEMOKINE; CXCL13 CHEMOKINE; CXCL2 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GAMMA INTERFERON RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; METHIONINE SULFOXIDE REDUCTASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES; RETINOID RELATED ORPHAN RECEPTOR GAMMA; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A;

ADIPOQ GENE; AGT GENE; ANIMAL CELL; ANIMAL TISSUE; APOE GENE; ARTICLE; B LYMPHOCYTE; C3 GENE; CCL19 GENE; CCL2 GENE; CCL21 GENE; CCL3 GENE; CCL4 GENE; CCL5 GENE; CCL7 GENE; CELL COMPOSITION; CELL FRACTIONATION; CELL POPULATION; CONTROLLED STUDY; CRP GENE; CSF1 GENE; CXCL1 GENE; CXCL10 GENE; CXCL12 GENE; CXCL13 GENE; CXCL2 GENE; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GATA3 GENE; GENE; GENE EXPRESSION PROFILING; GRANULOCYTE; HIF1A GENE; HOMEOSTASIS; IDO GENE; IFNG GENE; IL10 GENE; IL12A GENE; IL1B GENE; IL1RN GENE; IL2 GENE; IL4 GENE; IL5 GENE; IL6 GENE; IMMUNOMODULATION; INTERMETHOD COMPARISON; INTRAABDOMINAL FAT; LEP GENE; LEUKOCYTE; LIPID STORAGE; LPL GENE; LYMPHOID ORGAN; MACROPHAGE; MICROENVIRONMENT; MIF GENE; MOUSE; MSR1 GENE; NFKB GENE; NONHUMAN; NOS2 GENE; NOS3 GENE; OMENTAL WHITE ADIPOSE TISSUE; PARAMETRIAL WHITE ADIPOSE TISSUE; PERITONEAL SEROUS FLUID; PROM1 GENE; QUANTITATIVE ANALYSIS; RETN GENE; RETROPERITONEAL WHITE ADIPOSE TISSUE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RORC GENE; STEM CELL; STROMAL VASCULAR FRACTION; T LYMPHOCYTE; TBX21 GENE; TGFB GENE; TNFA GENE; VEGFA GENE; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANALYSIS OF VARIANCE; ANIMALS; ASCITIC FLUID; CELLULAR MICROENVIRONMENT; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; IMMUNOMODULATION; INTRA-ABDOMINAL FAT; LEUKOCYTES; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; REAL-TIME POLYMERASE CHAIN REACTION;

MURINAE; MUS;

EID: 84878910322     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066477     Document Type: Article

References (39)

1. Caspar-Bauguil S, Cousin B, Galinier A, Segafredo C, Nibbelink M, et al. (2005) Adipose tissues as an ancestral immune organ: site-specific change in obesity. FEBS Lett 579: 3487-3492.
2. Park HT, Lee ES, Cheon YP, Lee DR, Yang KS, et al. (2012) The relationship between fat depot-specific preadipocyte differentiation and metabolic syndrome in obese women. Clin Endocrinol (Oxf) 76: 59-66.
3. Baglioni S, Cantini G, Poli G, Francalanci M, Squecco R, et al. (2012) Functional differences in visceral and subcutaneous fat pads originate from differences in the adipose stem cell. PLoS One 7: e36569.
4. Linder K, Arner P, Flores-Morales A, Tollet-Egnell P, Norstedt G, (2004) Differentially expressed genes in visceral or subcutaneous adipose tissue of obese men and women. J Lipid Res 45: 148-154.
5. Montague CT, Prins JB, Sanders L, Zhang J, Sewter CP, et al. (1998) Depot-related gene expression in human subcutaneous and omental adipocytes. Diabetes 47: 1384-1391.
6. Lee MJ, Wu Y, Fried SK (2012) Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications. Mol Aspects Med.
7. Foster MT, Shi H, Softic S, Kohli R, Seeley RJ, et al. (2011) Transplantation of non-visceral fat to the visceral cavity improves glucose tolerance in mice: investigation of hepatic lipids and insulin sensitivity. Diabetologia 54: 2890-2899.
8. Wueest S, Yang X, Liu J, Schoenle EJ, Konrad D, (2012) Inverse regulation of basal lipolysis in perigonadal and mesenteric fat depots in mice. Am J Physiol Endocrinol Metab 302: E153-160.
9. Bjorntorp P, (1990) "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 10: 493-496.
10. Foster MT, Shi H, Seeley RJ, Woods SC, (2010) Transplantation or removal of intra-abdominal adipose tissue prevents age-induced glucose insensitivity. Physiol Behav 101: 282-288.
11. Gerber SA, Rybalko VY, Bigelow CE, Lugade AA, Foster TH, et al. (2006) Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth. Am J Pathol 169: 1739-1752.
12. Khan SM, Funk HM, Thiolloy S, Lotan TL, Hickson J, et al. (2010) In vitro metastatic colonization of human ovarian cancer cells to the omentum. Clin Exp Metastasis 27: 185-196.
13. Berberich S, Dahne S, Schippers A, Peters T, Muller W, et al. (2008) Differential molecular and anatomical basis for B cell migration into the peritoneal cavity and omental milky spots. J Immunol 180: 2196-2203.
14. Yu G, Wu X, Kilroy G, Halvorsen YD, Gimble JM, et al. (2011) Isolation of murine adipose-derived stem cells. Methods Mol Biol 702: 29-36.
15. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408.
16. Kwon EY, Shin SK, Cho YY, Jung UJ, Kim E, et al. (2012) Time-course microarrays reveal early activation of the immune transcriptome and adipokine dysregulation leads to fibrosis in visceral adipose depots during diet-induced obesity. BMC Genomics 13: 450.
17. Brake DK, Smith EO, Mersmann H, Smith CW, Robker RL, (2006) ICAM-1 expression in adipose tissue: effects of diet-induced obesity in mice. Am J Physiol Cell Physiol 291: C1232-1239.
18. Kawanishi N, Yano H, Yokogawa Y, Suzuki K, (2010) Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice. Exerc Immunol Rev 16: 105-118.
19. Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR, (2008) Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 57: 3239-3246.
20. Ray A, Dittel BN (2010) Isolation of mouse peritoneal cavity cells. J Vis Exp.
21. Sandoval P, Loureiro J, Gonzalez-Mateo G, Perez-Lozano ML, Maldonado-Rodriguez A, et al. (2010) PPAR-gamma agonist rosiglitazone protects peritoneal membrane from dialysis fluid-induced damage. Lab Invest 90: 1517-1532.
22. Rangel-Moreno J, Moyron-Quiroz JE, Carragher DM, Kusser K, Hartson L, et al. (2009) Omental milky spots develop in the absence of lymphoid tissue-inducer cells and support B and T cell responses to peritoneal antigens. Immunity 30: 731-743.
23. Yu J, Wei M, Mao H, Zhang J, Hughes T, et al. (2009) CD94 defines phenotypically and functionally distinct mouse NK cell subsets. J Immunol 183: 4968-4974.
24. Smyth MJ, Cretney E, Kelly JM, Westwood JA, Street SE, et al. (2005) Activation of NK cell cytotoxicity. Mol Immunol 42: 501-510.
25. Ghosn EE, Cassado AA, Govoni GR, Fukuhara T, Yang Y, et al. (2010) Two physically, functionally, and developmentally distinct peritoneal macrophage subsets. Proc Natl Acad Sci U S A 107: 2568-2573.
26. Rubtsova K, Marrack P, Rubtsov AV, (2012) Age-associated B cells: are they the key to understanding why autoimmune diseases are more prevalent in women? Expert Rev Clin Immunol 8: 5-7.
27. Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, et al. (2008) A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity 28: 639-650.
28. Dromard C, Bourin P, Andre M, De Barros S, Casteilla L, et al. (2011) Human adipose derived stroma/stem cells grow in serum-free medium as floating spheres. Exp Cell Res 317: 770-780.
29. Macotela Y, Emanuelli B, Mori MA, Gesta S, Schulz TJ, et al. (2012) Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes 61: 1691-1699.
30. Fang S, Wei J, Pentinmikko N, Leinonen H, Salven P, (2012) Generation of functional blood vessels from a single c-kit+ adult vascular endothelial stem cell. PLoS Biol 10: e1001407.
31. Montecino-Rodriguez E, Dorshkind K, (2006) New perspectives in B-1 B cell development and function. Trends Immunol 27: 428-433.
32. Horikawa K, Takatsu K, (2006) Interleukin-5 regulates genes involved in B-cell terminal maturation. Immunology 118: 497-508.
33. Ansel KM, Harris RB, Cyster JG, (2002) CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity 16: 67-76.
34. Poe JC, Smith SH, Haas KM, Yanaba K, Tsubata T, et al. (2011) Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PLoS One 6: e22464.
35. Matsushita T, Tedder TF, (2011) Identifying regulatory B cells (B10 cells) that produce IL-10 in mice. Methods Mol Biol 677: 99-111.
36. Rubtsov AV, Rubtsova K, Fischer A, Meehan RT, Gillis JZ, et al. (2011) Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c(+) B-cell population is important for the development of autoimmunity. Blood 118: 1305-1315.
37. Zhang Y, Bellows CF, Kolonin MG, (2010) Adipose tissue-derived progenitor cells and cancer. World J Stem Cells 2: 103-113.
38. Kidd S, Spaeth E, Watson K, Burks J, Lu H, et al. (2012) Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS One 7: e30563.
39. Tchkonia T, Lenburg M, Thomou T, Giorgadze N, Frampton G, et al. (2007) Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns. Am J Physiol Endocrinol Metab 292: E298-307.