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Volumn 14, Issue 10, 2015, Pages 1559-1567

IGF1 regulates PKM2 function through Akt phosphorylation

Author keywords

HIF1 ; IGF1; IGFIR; PKM2

Indexed keywords

GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; METFORMIN; PROTEIN KINASE B; PYRUVATE KINASE; PYRUVATE KINASE M2; SOMATOMEDIN C; STAT3 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; GLUCOSE; HEXOKINASE; MEMBRANE PROTEIN; THYROID HORMONE; THYROID HORMONE-BINDING PROTEINS;

EID: 84943803984     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1026490     Document Type: Article
Times cited : (45)

References (29)
  • 1
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • PMID: 21508971
    • Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 2011; 11: 325-37; PMID: 21508971; http://dx. doi. org/10. 1038/nrc3038.
    • (2011) Nat Rev Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 2
    • 84886704519 scopus 로고    scopus 로고
    • Nuclear PKM2 regulates the Warburg effect
    • PMID: 24013426
    • Yang W, Lu Z. Nuclear PKM2 regulates the Warburg effect. Cell Cycle 2013; 12: 3154-8; PMID: 24013426.
    • (2013) Cell Cycle , vol.12 , pp. 3154-3158
    • Yang, W.1    Lu, Z.2
  • 3
    • 84871757347 scopus 로고    scopus 로고
    • Dual roles of PKM2 in cancer metabolism
    • PMID: 23212076
    • Wu S, Le H. Dual roles of PKM2 in cancer metabolism. Acta Biochim Biophys Sinica 2013; 45: 27-35; PMID: 23212076.
    • (2013) Acta Biochim Biophys Sinica , vol.45 , pp. 27-35
    • Wu, S.1    Le, H.2
  • 4
    • 84920201918 scopus 로고    scopus 로고
    • PKM2 contributes to cancer metabolism
    • PMID: 24508027
    • Wong N, Ojo D, Yan J, Tang D. PKM2 contributes to cancer metabolism. Cancer Lett 2014; 356: 184-91; PMID: 24508027; http://dx. doi. org/10. 1016/j. canlet. 2014. 01. 031.
    • (2014) Cancer Lett , vol.356 , pp. 184-191
    • Wong, N.1    Ojo, D.2    Yan, J.3    Tang, D.4
  • 5
    • 85011941144 scopus 로고    scopus 로고
    • Alternative splicing: Dose-dependent splicing
    • Alderton GK. Alternative splicing: dose-dependent splicing. Nat Rev Cancer 2012; 12: 153-153.
    • (2012) Nat Rev Cancer , vol.12 , pp. 153
    • Alderton, G.K.1
  • 6
    • 78349269485 scopus 로고    scopus 로고
    • Human pyruvate kinase M2: A multifunctional protein
    • PMID: 20857498
    • Gupta V, Bamezai RNK. Human pyruvate kinase M2: A multifunctional protein. Protein Sci 2010; 19: 2031-44; PMID: 20857498.
    • (2010) Protein Sci , vol.19 , pp. 2031-2044
    • Gupta, V.1    Bamezai, R.N.K.2
  • 7
    • 84858062077 scopus 로고    scopus 로고
    • PKM2 enters the Morpheein academy
    • PMID: 22405271
    • Semenova G, Chernoff J. PKM2 enters the Morpheein academy. Mol Cell 2012; 45: 583-4; PMID: 22405271.
    • (2012) Mol Cell , vol.45 , pp. 583-584
    • Semenova, G.1    Chernoff, J.2
  • 8
    • 84879512941 scopus 로고    scopus 로고
    • Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-Cadherin-dependent manner in gastric cancer cells
    • PMID: 23840737
    • Wang LY, Liu YP, Chen LG, Chen YL, Tan L, Liu JJ, Jazag A, Ren JL, Guleng B. Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-Cadherin-dependent manner in gastric cancer cells. PLoS ONE 2013; 8: e67542; PMID: 23840737.
    • (2013) PLoS ONE , vol.8
    • Wang, L.Y.1    Liu, Y.P.2    Chen, L.G.3    Chen, Y.L.4    Tan, L.5    Liu, J.J.6    Jazag, A.7    Ren, J.L.8    Guleng, B.9
  • 9
    • 77449160135 scopus 로고    scopus 로고
    • PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect
    • PMID: 19920249
    • Dang CV. PKM2 tyrosine phosphorylation and glutamine metabolism signal a different view of the Warburg effect. Sci Signal 2009; 2: pe75; PMID: 19920249.
    • (2009) Sci Signal , vol.2
    • Dang, C.V.1
  • 11
    • 79957567239 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    • PMID: 21620138
    • Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 2011; 145: 732-44; PMID: 21620138; http://dx. doi. org/10. 1016/j. cell. 2011. 03. 054.
    • (2011) Cell , vol.145 , pp. 732-744
    • Luo, W.1    Hu, H.2    Chang, R.3    Zhong, J.4    Knabel, M.5    O'Meally, R.6    Cole, R.N.7    Pandey, A.8    Semenza, G.L.9
  • 13
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • PMID: 17604717 Dec 2]
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell [Internet] 2007 [cited 2014 Dec 2]; 129: 1261-74. Available from: http://www. pubmedcen tral. nih. gov/articlerender. fcgi?artidD2756685&toolDpm centrez&rendertypeDabstract; PMID: 17604717.
    • (2014) Cell [Internet] 2007 [cited , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 14
    • 35148828429 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 (HIF-1) pathway
    • Nov 6]
    • Semenza GL. Hypoxia-inducible factor 1 (HIF-1) pathway. Sci STKE [Internet] 2007 [cited 2014 Nov 6]; 2007: cm8. Available from: http://www. ncbi. nlm. nih. gov/pubmed/17925579.
    • (2014) Sci STKE [Internet] 2007 [cited , vol.2007
    • Semenza, G.L.1
  • 15
    • 84882321254 scopus 로고    scopus 로고
    • Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes
    • PMID: 23836898
    • Roberts DJ, Tan-Sah VP, Smith JM, Miyamoto S. Akt phosphorylates HK-II at Thr-473 and increases mitochondrial HK-II association to protect cardiomyocytes. J Biol Chem 2013; 288: 23798-806; PMID: 23836898; http://dx. doi. org/10. 1074/jbc. M113. 482026.
    • (2013) J Biol Chem , vol.288 , pp. 23798-23806
    • Roberts, D.J.1    Tan-Sah, V.P.2    Smith, J.M.3    Miyamoto, S.4
  • 16
    • 82155192703 scopus 로고    scopus 로고
    • MUC1-C oncoprotein regulates glycolysis and pyruvate kinase m2 activity in cancer cells
    • PMID: 22140559
    • Kosugi M, Ahmad R, Alam M, Uchida Y, Kufe D. MUC1-C oncoprotein regulates glycolysis and pyruvate kinase m2 activity in cancer cells. PLoS One 2011; 6: e28234; PMID: 22140559; http://dx. doi. org/10. 1371/journal. pone. 0028234.
    • (2011) PLoS One , vol.6
    • Kosugi, M.1    Ahmad, R.2    Alam, M.3    Uchida, Y.4    Kufe, D.5
  • 18
    • 84906894979 scopus 로고    scopus 로고
    • Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth
    • PMID: 24861463
    • Tsouko E, Khan AS, White MA, Han JJ, Shi Y, Merchant FA, Sharpe MA, Xin L, Frigo DE. Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis 2014; 3: e103; PMID: 24861463.
    • (2014) Oncogenesis , vol.3
    • Tsouko, E.1    Khan, A.S.2    White, M.A.3    Han, J.J.4    Shi, Y.5    Merchant, F.A.6    Sharpe, M.A.7    Xin, L.8    Frigo, D.E.9
  • 19
    • 84905187426 scopus 로고    scopus 로고
    • Regulation of the pentose phosphate pathway in cancer
    • PMID: 25015087
    • Jiang P, Du W, Wu M. Regulation of the pentose phosphate pathway in cancer. Protein Cell 2014; 5: 592-602; PMID: 25015087; http://dx. doi. org/10. 1007/s13238-014-0082-8.
    • (2014) Protein Cell , vol.5 , pp. 592-602
    • Jiang, P.1    Du, W.2    Wu, M.3
  • 20
    • 84904969433 scopus 로고    scopus 로고
    • The pentose phosphate pathway and cancer
    • PMID: 25037503
    • Patra KC, Hay N. The pentose phosphate pathway and cancer. Trend Biochem Sci 2014; 39: 347-54; PMID: 25037503; http://dx. doi. org/10. 1016/j. tibs. 2014. 06. 005.
    • (2014) Trend Biochem Sci , vol.39 , pp. 347-354
    • Patra, K.C.1    Hay, N.2
  • 21
    • 84870598190 scopus 로고    scopus 로고
    • ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
    • Available from
    • Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol [Internet] 2012; 14: 1295-304. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artidD 3511602&toolDpmcentrez&rendertypeDabstract.
    • (2012) Nat Cell Biol [Internet] , vol.14 , pp. 1295-1304
    • Yang, W.1    Zheng, Y.2    Xia, Y.3    Ji, H.4    Chen, X.5    Guo, F.6    Lyssiotis, C.A.7    Aldape, K.8    Cantley, L.C.9    Lu, Z.10
  • 22
    • 84890284278 scopus 로고    scopus 로고
    • Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells
    • PMID: 24142698
    • Yu Z, Zhao X, Huang L, Zhang T, Yang F, Xie L, Song S, Miao P, Zhao L, Sun X, et al. Proviral insertion in murine lymphomas 2 (PIM2) oncogene phosphorylates pyruvate kinase M2 (PKM2) and promotes glycolysis in cancer cells. J Biol Chem 2013; 288: 35406-16; PMID: 24142698; http://dx. doi. org/10. 1074/jbc. M113. 508226.
    • (2013) J Biol Chem , vol.288 , pp. 35406-35416
    • Yu, Z.1    Zhao, X.2    Huang, L.3    Zhang, T.4    Yang, F.5    Xie, L.6    Song, S.7    Miao, P.8    Zhao, L.9    Sun, X.10
  • 24
    • 84890284278 scopus 로고    scopus 로고
    • PIM2 phosphorylates PKM2 and promotes Glycolysis in Cancer Cells
    • Available from
    • Yu Z, Huang L, Zhang T, Yang F, Xie L, Liu J, Song S, Miao P, Zhao L, Zhao X, et al. PIM2 phosphorylates PKM2 and promotes Glycolysis in Cancer Cells. The Journal of biological chemistry [Internet] 2013; 288: 35406-16. Available from: http://www. jbc. org/con tent/288/49/35406. short?rssD1&utm_sourceDfeedburn er&utm_mediumDfeed&utm_campaignDFeed: CJBC_ MetabolismC(JBC_Metabolism).
    • (2013) The Journal of biological chemistry [Internet] , vol.288 , pp. 35406-35416
    • Yu, Z.1    Huang, L.2    Zhang, T.3    Yang, F.4    Xie, L.5    Liu, J.6    Song, S.7    Miao, P.8    Zhao, L.9    Zhao, X.10
  • 25
    • 84919913425 scopus 로고    scopus 로고
    • Molecular simulation of Tyr105 phosphorylated pyruvate kinase M2 to understand its structure and dynamics
    • PMID: 25208557 Oct 30]
    • Kalaiarasan P, Subbarao N, Bamezai RN. Molecular simulation of Tyr105 phosphorylated pyruvate kinase M2 to understand its structure and dynamics. J Mol Model [Internet] 2014 [cited 2014 Oct 30]; 20: 2447. Available from: http://www. ncbi. nlm. nih. gov/pubmed/25208557; PMID: 25208557.
    • (2014) J Mol Model [Internet] 2014 [cited , vol.20 , pp. 2447
    • Kalaiarasan, P.1    Subbarao, N.2    Bamezai, R.N.3
  • 26
    • 60549111398 scopus 로고    scopus 로고
    • Is Akt the "Warburg kinase"?-Aktenergy metabolism interactions and oncogenesis
    • PMID: 19130886
    • Robey RB, Hay N. Is Akt the "Warburg kinase"?-Aktenergy metabolism interactions and oncogenesis. Semin Cancer Biol 2009; 19: 25-31; PMID: 19130886.
    • (2009) Semin Cancer Biol , vol.19 , pp. 25-31
    • Robey, R.B.1    Hay, N.2
  • 27
    • 84880000375 scopus 로고    scopus 로고
    • Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2
    • PMID: 23837608
    • Iqbal MA, Siddiqui FA, Gupta V, Chattopadhyay S, Gopinath P, Kumar B, Manvati S, Chaman N, Bamezai RNK. Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2. Mol Cancer [Internet] 2013; 12: 72. Available from: http://www. pubmedcentral. nih. gov/articlerender. fcgi?artidD3710280&toolDpmcentrez &rendertypeDabstract; PMID: 23837608.
    • (2013) Mol Cancer [Internet] , vol.12 , pp. 72
    • Iqbal, M.A.1    Siddiqui, F.A.2    Gupta, V.3    Chattopadhyay, S.4    Gopinath, P.5    Kumar, B.6    Manvati, S.7    Chaman, N.8    Bamezai, R.N.K.9
  • 28
    • 33645786505 scopus 로고    scopus 로고
    • Development of novel therapeutic strategies that target HIF-1
    • PMID: 16548775
    • Semenza GL. Development of novel therapeutic strategies that target HIF-1. Expert Opin Ther Targets 2006; 10: 267-80; PMID: 16548775.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 267-280
    • Semenza, G.L.1
  • 29
    • 33750341917 scopus 로고    scopus 로고
    • Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors
    • Oct 1
    • Su H, Bodenstein C, Dumont RA, Seimbille Y, Dubinett S, Phelps ME, Herschman H, Czernin J, Weber W. Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors. Clin Cancer Res. 2006 Oct 1; 12(19): 5659-67.
    • (2006) Clin Cancer Res , vol.12 , Issue.19 , pp. 5659-5667
    • Su, H.1    Bodenstein, C.2    Dumont, R.A.3    Seimbille, Y.4    Dubinett, S.5    Phelps, M.E.6    Herschman, H.7    Czernin, J.8    Weber, W.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.