Cohort profile: Estonian biobank of the Estonian genome center, university of Tartu

International Journal of Epidemiology

Volumn 44, Issue 4, 2015, Pages 1137-1147

  Leitsalu, Liis ^a,b   Haller, Toomas ^a   Esko, Tõnu ^a,c,d,e   Tammesoo, Mari Liis ^a   Alavere, Helene ^a   Snieder, Harold ^a,f   Perola, Markus ^a,g,h   Ng, Pauline C ^a,i   Mägi, Reedik ^a   Milani, Lili ^a   Fischer, Krista ^a   Metspalu, Andres ^a,b  

^a UNIVERSITY OF TARTU   (Estonia)

^b UNIVERSITY OF TARTU   (Estonia)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f UNIVERSITY OF GRONINGEN   (Netherlands)

^g NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^h UNIVERSITY OF HELSINKI   (Finland)

ⁱ GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ACADEMIC RESEARCH; ADULT; BLOOD; COHORT ANALYSIS; DATABASE; DNA; GENOME; PARTICIPATORY APPROACH; RESEARCH INSTITUTION;

AGE DISTRIBUTION; ARTICLE; BIOBANK; BLOOD ANALYSIS; ESTONIAN (PEOPLE); FOLLOW UP; GENDER; GENERAL PRACTITIONER; GENETIC DATABASE; GOOD LABORATORY PRACTICE; HEALTH CARE FACILITY; HEALTH STATUS; HUMAN; HUMAN GENOME PROJECT; ICD-10; LEUKOCYTE; MEDICAL HISTORY; PRIORITY JOURNAL; QUESTIONNAIRE; REGISTER; STANDARDIZATION; ADOLESCENT; ADULT; AGED; COHORT ANALYSIS; ESTONIA; FACTUAL DATABASE; FEMALE; GENETICS; HUMAN GENOME; INTERNATIONAL CLASSIFICATION OF DISEASES; LIFESTYLE; MALE; MIDDLE AGED; PUBLIC HEALTH; STANDARDS; TRENDS; VERY ELDERLY; YOUNG ADULT;

ESTONIA; TARTU;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL SPECIMEN BANKS; COHORT STUDIES; DATABASES, FACTUAL; ESTONIA; FEMALE; GENOME, HUMAN; HUMANS; INTERNATIONAL CLASSIFICATION OF DISEASES; LIFE STYLE; MALE; MIDDLE AGED; PUBLIC HEALTH; YOUNG ADULT;

EID: 84943759545     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyt268     Document Type: Article

References (74)

1. Metspalu A. The Estonian Genome Project. Drug Dev Res 2004;62:97-101.
2. Metspalu A, Köhler F, Laschinski G, Ganten D, Roots I. [The Estonian Genome Project in the context of European genome research.] Dtsch MedWochenschr 2004;129(Suppl):S25-28.
3. Human Genes Research Act. 2000. (7 January 2014, date last accessed).
4. Estonian Genome Center of the University of Tartu. 2013. (7 January 2014, date last accessed).
5. Population pyramid of Estonia: 2011. Sta. Est Stat Bundesamt Deutschl. 2011. (7 January 2014, date last accessed).
6. Holle R, Happich M, Löwel H, Wichmann HE. KORA - a research platform for population based health research. Gesundheitswesen 2005;67(Suppl. 1):S19-25.
7. Health 2000. 2013. (4 June 2013, date last accessed).
8. Framingham. 2013. Original Cohort Framingham Heart Study. (28 June 2013, date last accessed).
9. Estonian Health Insurance Fund. 2013. Family physicians. (14 January 2014, date last accessed).
10. Knaapila A, Tuorila H, Silventoinen K et al. Food neophobia shows heritable variation in humans. Physiol Behav 2007;91:573-78.
11. Wichmann H-E, Kaaks R, Hoffmann W et al. The German National Cohort. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2012;55:781-87.
12. Roenneberg T, Kuehnle T, Juda M et al. Epidemiology of the human circadian clock. Sleep Med Rev 2007; 11:429-38.
13. Sheehan DV, Lecrubier Y, Sheehan KH et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998; 59:22-33.
14. Gustavsson JP, Bergman H, Edman G et al. Swedish universities Scales of Personality (SSP): construction, internal consistency and normative data. Acta Psychiatr Scand 2000;102:217-25.
15. Costa PT, McCrae RR. Stability and change in personality assessment: the revised NEO Personality Inventory in the year 2000. J Pers Assess 1997;68:86-94.
16. ISO. ISO 9000 quality management (20 June 2013, date last accessed).
17. World Health Organization. International Classification of Diseases (ICD). (28 June 2013, date last accessed).
18. WHO Collaborating Centre. ATC/DDD Index. (28 June 2013, date last accessed).
19. United Nations Educational, Scientific and Cultural Organization. International Standard Classification of Education. (24 May 2013, date last accessed).
20. International Standard Classification of Occupations. (28 June 2013, date last accessed).
21. World Health Organization. Estonia. (14 January 2014, date last accessed).
22. Estonian Ministry of the Interior. Population Register. (13 January 2014, date last accessed).
23. National Institute for Health Development. Registers. (28 June 2013, date last accessed).
24. Estonian Health Insurance Fund. (28 June 2013, date last accessed).
25. eHealth. (17 September 2013, date last accessed)
26. Nelis M, Esko T, Magi R et al. Genetic structure of Europeans: a view from the North-East. PLoS One 2009;4:e5472.
27. Esko T, Mezzavilla M, NelisMet al. Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity. Eur J Hum Gene. 2012;20:111-16.
28. BBMRI. (14 January 2014, date last accessed).
29. BBMRI-LPC. (10 June 2013, date last accessed).
30. Home j Public Population Project in Genomics and Society. (14 January 2014, date last accessed).
31. Kettunen J, Tukiainen T, Sarin A-P et al. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet 2012; 44:269-76.
32. Illig T, Gieger C, Zhai G et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet 2010;42:137-41.
33. Codd V, Nelson CP, Albrecht E et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 2013; 45:422-27.
34. Den Hoed M Eijgelsheim M, Esko T et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet 2013;45:621-31.
35. Berndt SI, Gustafsson S,Magi R et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. NatGenet 2013;45:501-12.
36. Fernández-Rhodes L, Demerath EW, Cousimer DL et al. Association of adiposity genetic variants with menarche timing in 92,105 women of European descent. Am J Epidemiol 2013;178:451-60.
37. Gieger C, Radhakrishnan A, Cvejic A et al. New gene functions in megakaryopoiesis and platelet formation. Nature 2011;480:201-08.
38. Okada Y, Sim X, Go MJ et al. Meta-analysis identifies multiple loci associated with kidney function-related traits in East Asian populations. Nat Genet 2012;44:904-09.
39. Pattaro C, Kottgen A, Teumer A et al. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet 2012;8:e1002584.
40. Taal HR, St Pourcain B, Thiering E et al. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet 2013;45:713.
41. Bradfield JP, Taal HR, Timpson NJ et al. A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet 2012;44:526-31.
42. Codd V, Nelson CP, Albrecht E et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet 2013;45:422-27.
43. Day-Williams AG, Southam L, Panoutsopoulou K et al. A variant in MCF2L is associated with osteoarthritis. Am. J Hum Genet 2011;89:446-50.
44. Deloukas, P, Kanoni S, Willenborg C et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet 2012;45:25-33.
45. Ellinghaus D, Ellinghaus E, Rajan P et al. Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J. Hum Genet 2012;90:636-47.
46. Jacquemont S, Reymond A, Zufferey F et al. Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature 2011;478:97-102.
47. Morris AP, Voight BF, Teslovich TMet al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet; 2012;44:981-90.
48. Nikopensius T, Annilo T, Jagomagi T et al. Non-syndromic tooth agenesis associated with a nonsense mutation in ectodysplasin-A (EDA). J Dent Res 2013;92:507-11.
49. Tsoi LC, Spain SL, Knight J et al. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Na. Genet 2012;44:1341-48.
50. Verhoeven VJM, Hysi PG, Wojciechowski R et al. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet;2013;45:712.
51. Võsa U, Vooder T, Kolde R et al. Meta-analysis of microRNA expression in lung cancer. Int J Cancer 2013;132:2884-93.
52. ArcOGEN collaborators. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 2012;380:815-23.
53. Yang J, Loos RJ, Powell JE et al. FTO genotype is associated with phenotypic variability of body mass index. Nature 2012;490:267-72.
54. Walters RG, Coin L, Ruokonen A et al. Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity. PLoS One 2013;8:e58048.
55. De Moor M, Costa P, Terracciano A et al. Meta-analysis of genome-wide association studies for personality. Mol Psychiatry 2012;17:337-49.
56. Terracciano A, Esko T, Sutan AR et al. Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking. Transl Psychiatry 2011;1:e49.
57. Mõttus R, Real A, Allik J et al. Personality traits and eating habits in a large sample of Estonians. Health Psychol 2012;31:806-14.
58. Rietveld CA, Medland SE, Derringer J et al. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science 2013;340:467-71.
59. Amin N, Hottenga J, Hansell N et al. Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions. Eur J Hum Genet 2013;21:876-82.
60. Middeldorp CM, de Moor M, McGrath L et al. The genetic association between personality and major depression or bipolar disorder. A polygenic score analysis using genome-wide association data. Transl. Psychiatry 2011;1:e50.
61. Erhardt A, Akula N, Schumacher J et al. Replication and metaanalysis of TMEM132D gene variants in panic disorder. Transl Psychiatry 2012;2:e156.
62. Luciano M, Lopez L, de Moor M et al. Longevity candidate genes and their association with personality traits in the elderly. Am J. Med Gene. B Neuropsychiatr Genet 2011. doi: 10.1002/ajmg.b.32013.
63. Ivanov M, Kals M, Kacevska Met al. In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes. Nucleic Acids Res 2013;41:e72.
64. Lener MR, Gupta S, Scott R et al. Can selenium levels act as a marker of colorectal cancer risk? BMC Cancer 2013;13:214.
65. Kumar V, Westra H-J, Karjalainen J et al. Human disease-associated genetic variation impacts large intergenic non-coding RNA expression. PLoS Genet 2013;9:e1003201.
66. Köttgen A, Albrecht E, Teumer A et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet 2013;45:145-54.
67. Lokk K, Vooder T, Kolde R et al. Methylation markers of earlystage non-small cell lung cancer. PLoS One 2012;7:e39813.
68. Min JL, Nicholson G, Halgrimsdottir I et al. Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes. PLoS Genet 2012;8:e1002505.
69. Scott RA, Lagon V, Welch RP et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 2012;44:991-1005.
70. Van der Harst P, Zhang W, Leach I et al. Seventy-five genetic loci influencing the human red blood cell. Nature 2012;492:369-75.
71. University of Tartu Estonian Gene Project. Gene Donor Consent Form. (4 Jul 2013, date last accessed).
72. e-Estonia. X-Road. (28 June 2013, date last accessed).
73. Statistics Estonia. (10 June 2013, date last accessed).
74. Research Ethics Committee of the University of Tartu. (14 January 2014, date last accessed)