Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking

Translational Psychiatry

Volumn 1, Issue , 2011, Pages

  Terracciano, A ^a   Esko, T ^b,c   Sutin, A R ^a   De Moor, M H M ^d   Meirelles, O ^a   Zhu, G ^e   Tanaka, T ^a   Giegling, I ^f   Nutile, T ^g   Realo, A ^b   Allik, J ^b   Hansell, N K ^e   Wright, M J ^e   Montgomery, G W ^e   Willemsen, G ^d   Hottenga, J J ^d   Friedl, M ^f   Ruggiero, D ^g   Sorice, R ^g   Sanna, S ^h   Cannas, A ^h   Raikkonen K ⁱ   Widen, E ⁱ   Palotie, A ^i,j   Eriksson, J G ^k   Cucca, F ^h   Krueger, R F ^l   Lahti, J ⁱ   Luciano, M ^m   Smoller, J W ⁿ   Van Duijn, C M ^o   Abecasis, G R ^p   Boomsma, D I ^d   Ciullo, M ^g   Costa, P T ^a   Ferrucci, L ^a   Martin, N G ^e   Metspalu, A ^b,c   Rujescu, D ^f   Schlessinger, D ^a   Uda, M ^h   more..

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF TARTU   (Estonia)

^c UNIVERSITY OF TARTU   (Estonia)

^d VU UNIVERSITY AMSTERDAM   (Netherlands)

^e QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^f UNIVERSITY OF MUNICH   (Germany)

^g INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

^h Milan Unit   (Italy)

ⁱ UNIVERSITY OF HELSINKI   (Finland)

^j WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^k NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^l UNIVERSITY OF MINNESOTA   (United States)

^m UNIVERSITY OF EDINBURGH   (United Kingdom)

ⁿ MASSACHUSETTS GENERAL HOSPITAL   (United States)

^o ERASMUS MEDICAL CENTER   (Netherlands)

^p UNIVERSITY OF MICHIGAN   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; CTNNA2 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; AUSTRALIA; CLASSIFICATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ESTONIA; FEMALE; FINLAND; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENETICS; GERMANY; HUMAN; ITALY; LONGITUDINAL STUDY; MALE; META ANALYSIS; METABOLISM; METHODOLOGY; MIDDLE AGED; MULTICENTER STUDY; NETHERLANDS; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES;

ADOLESCENT; ADULT; ALPHA CATENIN; AUSTRALIA; BALTIMORE; ESTONIA; FEMALE; FINLAND; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GERMANY; HUMANS; ITALY; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; NETHERLANDS; POLYMORPHISM, SINGLE NUCLEOTIDE; PSYCHOMOTOR AGITATION; YOUNG ADULT;

EID: 80054797850     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2011.42     Document Type: Article

References (72)

1. Wellcome Trust Case Control Consortium. Genome-wide association study of 14 000 cases of seven common diseases and 3000 shared controls. Nature 2007; 447: 661-678.
2. Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008; 40: 161-169. (Pubitemid 351171403)
3. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet 2011; 43: 429-435.
4. Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P, Middleton L et al. Meta-analysis and imputation refines the association of 15q25 with smoking quantity. Nat Genet 2010; 42: 436-440.
5. Shifman S, Bhomra A, Smiley S, Wray NR, James MR, Martin NG et al. A whole genome association study of neuroticism using DNA pooling. Mol Psychiatry 2008; 13: 302-312. (Pubitemid 351272652)
6. van den Oord EJCG, Kuo P-H, Hartmann AM, Webb BT, Moller H-J, Hettema JM et al. Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. Arch Gen Psychiatry 2008; 65: 1062-1071.
7. Terracciano A, Sanna S, Uda M, Deiana B, Usala G, Busonero F et al. Genome-wide association scan for five major dimensions of personality. Mol Psychiatry 2010; 15: 647-656.
8. Calboli FC, Tozzi F, Galwey NW, Antoniades A, Mooser V, Preisig M et al. A genome-wide association study of neuroticism in a population-based sample. PLoS One 2010; 5: e11504.
9. Verweij KJ, Zietsch BP, Medland SE, Gordon SD, Benyamin B, Nyholt DR et al. A genomewide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. Biol Psychol 2010; 85: 306-317.
10. de Moor MH, Costa PT, Terracciano A, Krueger RF, de Geus EJ, Toshiko T et al. Meta-analysis of genome-wide association studies for personality. Mol Psychiatry 2010 (in press).
11. Terracciano A, Tanaka T, Sutin AR, Sanna S, Deiana B, Lai S et al. Genome-wide association scan of trait depression. Biol Psychiatry 2010; 68: 811-817.
12. Merjonen P, Keltikangas-Järvinen L, Jokela M, Seppä lä I, Lyytikäinen L-P, Pulkki-Raback L et al. Hostility in adolescents and adults: a genome-wide association study of the Young Finns. Translational Psychiatry 2011; 1: e11.
13. Costa Jr PT, McCrae RR. Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) professional manual. Psychological Assessment Resources: Odessa, FL, 1992.
14. Zuckerman M, Kuhlman DM. Personality and risk-taking: common biosocial factors. J Pers 2000; 68: 999-1029.
15. Eysenck HJ, Eysenck SBG. On the unitary nature of extraversion. Acta Psychol 1967; 26: 383-390.
16. Whiteside SP, Lynam DR. The Five Factor Model and impulsivity: using a structural model of personality to understand impulsivity. Person Individ Differ 2001; 30: 669-689. (Pubitemid 33380663)
17. Smith GT, Fischer S, Cyders MA, Annus AM, Spillane NS, McCarthy DM. On the validity and utility of discriminating among impulsivity-like traits. Assessment 2007; 14: 155-170.
18. Zuckerman M. Sensation Seeking: Beyond the Optimal Level of Arousal. Lawrence Erlbaum Associates: Hillsdale, NJ, 1979.
19. Gray JA. The psychophysiological basis of introversion-extroversion. Behav Res Ther 1970; 8: 249-266.
20. Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psychiatry 1993; 50: 975-990. (Pubitemid 23361478)
21. Elliot AJ, Thrash TM. Approach-avoidance motivation in personality: approach and avoidance temperaments and goals. J Pers Soc Psychol 2002; 82: 804-818.
22. Terracciano A, McCrae RR, Brant LJ, Costa Jr PT. Hierarchical linear modeling analyses of NEO-PI-R scales in the Baltimore Longitudinal Study of Aging. Psychology Aging 2005; 20: 493-506. (Pubitemid 41572553)
23. McCrae RR, Terracciano A, Members of the Personality Profiles of Cultures Project. Universal features of personality traits from the observer's perspective: data from 50 cultures. J Person Soc Psychol 2005; 88: 547-561. (Pubitemid 40328311)
24. Costa Jr PT, Terracciano A, McCrae RR. Gender differences in personality traits across cultures: robust and surprising findings. J Person Social Psychol 2001; 81: 322-331. (Pubitemid 33594918)
25. Terracciano A, Lockenhoff CE, Crum RM, Bienvenu OJ, Costa Jr PT. Five-Factor Model personality profiles of drug users. BMC Psychiatry 2008; 8: 22.
26. Lucidi F, Giannini AM, Sgalla R, Mallia L, Devoto A, Reichmann S. Young novice driver subtypes: relationship to driving violations, errors and lapses. Accid Anal Prev 2010; 42: 1689-1696.
27. Samuels J, Bienvenu OJ, Cullen B, Costa Jr PT, Eaton WW, Nestadt G. Personality dimensions and criminal arrest. Compr Psychiatry 2004; 45: 275-280. (Pubitemid 38859645)
28. Ball SA, Carroll KM, Rounsaville BJ. Sensation seeking, substance abuse, and psychopathology in treatment-seeking and community cocaine abusers. J Consult Clin Psychol 1994; 62: 1053-1057. (Pubitemid 24328513)
29. Bagby RM, Vachon DD, Bulmash EL, Toneatto T, Quilty LC, Costa PT. Pathological gambling and the five-factor model of personality. Person Individ Differ 2007; 43: 873-880.
30. Fischer S, Smith GT. Binge eating, problem drinking, and pathological gambling: Linking behavior to shared traits and social learning. Person Individ Differ 2008; 44: 789-800.
31. Krueger RF, Hicks BM, Patrick CJ, Carlson SR, Iacono WG, McGue M. Etiologic connections among substance dependence, antisocial behavior, and personality: modeling the externalizing spectrum. J Abnorm Psychol 2002; 111: 411-424. (Pubitemid 34791142)
32. Young SE, Stallings MC, Corley RP, Krauter KS, Hewitt JK. Genetic and environmental influences on behavioral disinhibition. Am J Med Genet 2000; 96: 684-695.
33. Zietsch BP, Verweij KJ, Bailey JM, Wright MJ, Martin NG. Genetic and environmental influences on risky sexual behaviour and its relationship with personality. Behav Genet 2010; 40: 12-21.
34. Maremmani I, Pacini M, Perugi G. Addictive disorders, bipolar spectrum and the impulsive link: the psychopathology of a self-regenerating pathway. Heroin Addict Relat Clin Problems 2005; 7: 33-45. (Pubitemid 41497761)
35. Hegerl U, Himmerich H, Engmann B, Hensch T. Mania and attention-deficit/hyperactivity disorder: common symptomatology, common pathophysiology and common treatment? Curr Opin Psychiatry 2010; 23: 1-7.
36. McElroy SL, Pope Jr HG, Keck Jr PE, Hudson JI, Phillips KA, Strakowski SM. Are impulsecontrol disorders related to bipolar disorder? Compr Psychiatry 1996; 37: 229-240. (Pubitemid 26249540)
37. Moeller FG, Barratt ES, Dougherty DM, Schmitz JM, Swann AC. Psychiatric aspects of impulsivity. Am J Psychiatry 2001; 158: 1783-1793. (Pubitemid 33054770)
38. McCrae RR, Kurtz JE, Yamagata S, Terracciano A. Internal consistency, retest reliability, and their implications for personality scale validity. Pers Soc Psychol Rev 2011; 15: 28-50.
39. Jang KL, McCrae RR, Angleitner A, Riemann R, Livesley WJ. Heritability of facet-level traits in a cross-cultural twin sample: support for a hierarchical model of personality. J Pers Soc Psychol 1998; 74: 1556-1565. (Pubitemid 128658119)
40. Stoel RD, De Geus EJ, Boomsma DI. Genetic analysis of sensation seeking with an extended twin design. Behav Genet 2006; 36: 229-237. (Pubitemid 43673565)
41. Bevilacqua L, Doly S, Kaprio J, Yuan Q, Tikkanen R, Paunio T et al. A population-specific HTR2B stop codon predisposes to severe impulsivity. Nature 2010; 468: 1061-1066.
42. Pilia G, Chen WM, Scuteri A, Orrú M, Albai G, Dei M et al. Heritability of cardiovascular and personality traits in 6148 sardinians. PloS Genet 2006; 2: e132.
43. Cavalli-Sforza LL, Menozzi P, Piazza A. The History and Geography of Human Genes. Princeton University Press: Princeton, NJ, 1994.
44. Allik J, Realo A, MÃ mttus R, Esko T, Pullat J, Metspalu A. Variance determines self-observer agreement on the Big Five personality traits. J Res Person 2010; 44: 421-426.
45. De Fruyt F, De Bolle M, McCrae RR, Terracciano A, Costa Jr PT, Collaborators of the Adolescent Personality Profiles of Cultures Project. Assessing the universal structure of personality in early adolescence: the NEO-PI-R and NEO-PI-3 in 24 cultures. Assessment 2009; 16: 301-311.
46. Nelis M, Esko T, MÃ gi R, Zimprich F, Toncheva D, Karachanak S et al. Genetic structure of Europeans: a view from the north-east. PLoS One 2009; 4: e5472.
47. Terracciano A, Costa Jr PT, McCrae RR. Personality plasticity after age 30. Person Soc Psychol Bull 2006; 32: 999-1009. (Pubitemid 44060249)
48. Wright MJ, Martin NG. Brisbane adolescent twin study: outline of study methods and research projects. Aust J Psychol 2004; 56: 65-78. (Pubitemid 39216642)
49. Distel MA, Willemsen G, Ligthart L, Derom CA, Martin NG, Neale MC et al. Genetic covariance structure of the four main features of borderline personality disorder. J Person Disord 2010; 24: 427-444.
50. Medland SE, Nyholt DR, Painter JN, McEvoy BP, McRae AF, Zhu G et al. Common variants in the Trichohyalin gene are associated with straight hair in Europeans. Am J Hum Genet 2009; 85: 750-755.
51. Costa Jr PT, McCrae RR. The NEO-PI/NEO-FFI Manual Supplement. Psychological Assessment Resources Inc.: Odessa, FL, 1989.
52. Barker DJ, Osmond C, Forsen TJ, Kajantie E, Eriksson JG. Trajectories of growth among children who have coronary events as adults. N Engl J Med 2005; 353: 1802-1809. (Pubitemid 41549892)
53. Eriksson JG, Osmond C, Kajantie E, Forsen TJ, Barker DJ. Patterns of growth among children who later develop type 2 diabetes or its risk factors. Diabetologia 2006; 49: 2853-2858. (Pubitemid 44730287)
54. Rikkonen K, Pesonen AK, Heinonen K, Lahti J, Kajantie E, Forsen T et al. Infant growth and hostility in adult life. Psychosom Med 2008; 70: 306-313. (Pubitemid 351543492)
55. Boomsma DI, de Geus EJ, Vink JM, Stubbe JH, Distel MA, Hottenga JJ et al. Netherlands Twin Register: from twins to twin families. Twin Res Hum Genet 2006; 9: 849-857. (Pubitemid 46093769)
56. Willemsen G, de Geus EJ, Bartels M, van Beijsterveldt CE, Brooks AI, Estourgie-van Burk GF et al. The Netherlands Twin Register biobank: a resource for genetic epidemiological studies. Twin Res Hum Genet 2010; 13: 231-245.
57. Zuckerman M. Dimensions of sensation seeking. J Consult Clin Psychol 1971; 36: 45-52.
58. Aluja A, García Ó , García LF. Relationships among extraversion, openness to experience, and sensation seeking. Person Individ Differ 2003; 35: 671-680. (Pubitemid 36831771)
59. Zeggini E. Next-generation association studies for complex traits. Nat Genet 2011; 43: 287-288.
60. Perneger TV. What's wrong with Bonferroni adjustments. BMJ 1998; 316: 1236-1238. (Pubitemid 28171344)
61. Ioannidis JP, Tarone R, McLaughlin JK. The false-positive to false-negative ratio in epidemiologic studies. Epidemiology 2011; 22: 450-456.
62. Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R et al. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci USA 2009; 106: 7501-7506.
63. Lesch KP, Timmesfeld N, Renner TJ, Halperin R, Roser C, Nguyen TT et al. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J Neural Transm 2008; 115: 1573-1585.
64. Chu TT, Liu Y. An integrated genomic analysis of gene-function correlation on schizophrenia susceptibility genes. J Hum Genet 2010; 55: 285-292.
65. Francks C, Maegawa S, Lauren J, Abrahams BS, Velayos-Baeza A, Medland SE et al. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Mol Psychiatry 2007; 12: 1129-1139, 1057. (Pubitemid 350191361)
66. Abe K, Chisaka O, Van Roy F, Takeichi M. Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin. Nat Neurosci 2004; 7: 357-363. (Pubitemid 38429175)
67. Smith A, Bourdeau I, Wang J, Bondy CA. Expression of catenin family members CTNNA1, CTNNA2, CTNNB1 and JUP in the primate prefrontal cortex and hippocampus. Brain Res Mol Brain Res 2005; 135: 225-231. (Pubitemid 40602414)
68. Park C, Falls W, Finger JH, Longo-Guess CM, Ackerman SL. Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation. Nat Genet 2002; 31: 279-284.
69. Uemura M, Takeichi M. Alpha N-catenin deficiency causes defects in axon migration and nuclear organization in restricted regions of the mouse brain. Dev Dyn 2006; 235: 2559-2566. (Pubitemid 44325268)
70. Purcell SM, Wray NR, Stone JL, Visscher PM, O'Donovan MC, Sullivan PF et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009; 460: 748-752.
71. McMahon FJ, Akula N, Schulze TG, Muglia P, Tozzi F, Detera-Wadleigh SD et al. Metaanalysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1. Nat Genet 2010; 42: 128-131.
72. Pruim RJ, Welch RP, Sanna S, Teslovich TM, Chines PS, Gliedt TP et al. LocusZoom: regional visualization of genome-wide association scan results. Bioinformatics 2010; 26: 2336-2337.