β-cell identity in type 2 diabetes: Lost or found?

Diabetes

Volumn 64, Issue 8, 2015, Pages 2698-2700

  Butler, Alexandra E ^a   Dhawan, Sangeeta ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PLAQUE; ANIMAL; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PATHOLOGY;

ANIMALS; DIABETES MELLITUS, TYPE 2; GLUCAGON-SECRETING CELLS; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; PLAQUE, AMYLOID;

EID: 84943655887     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0550     Document Type: Note

References (21)

1. Butler AE, Janson J, Bonner-Weir S, Ritzel R., Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003; 52:102-110
2. Costes S, Langen R, Gurlo T., Matveyenko AV, Butler PC. β-Cell failure in type 2 diabetes: a case of asking too much of too few? Diabetes 2013; 62:327-335
3. Robertson R, Zhou H, Zhang T., Harmon JS. Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes. Cell Biochem Biophys 2007; 48:139-146
4. Wikstrom JD, Katzman SM, Mohamed H, et al Beta-cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes 2007; 56:2569-2578
5. Meier JJ. Linking the genetics of type 2 diabetes with low birth weight: a role for prenatal islet maldevelopment? Diabetes 2009; 58:1255-1256
6. Talchai C, Xuan S, Lin H.V., Sussel L., Accili D. Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell 2012; 150:1223-1234
7. Spijker HS, Song H, Ellenbroek J.H., et al. Loss of β-cell identity occurs in type 2 diabetes and is associated with islet amyloid deposits. Diabetes 2015; 64: 2928-2938
8. Henquin JC, Rahier J. Pancreatic alpha cell mass in European subjects with type 2 diabetes. Diabetologia 2011; 54:1720-1725
9. Butler AE, Campbell-Thompson M, Gurlo T., Dawson DW, Atkinson M, Butler PC. Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 2013; 62:2595-2604
10. Butler AE, Robertson RP, Hernandez R, Matveyenko A.V., Gurlo T., Butler PC. Beta cell nuclear musculoaponeurotic fibrosarcoma oncogene family A (MafA) is deficient in type 2 diabetes. Diabetologia 2012; 55:2985-2988
11. Guo S, Dai C, Guo M., et al. Inactivation of specific β cell transcription factors in type 2 diabetes. J Clin Invest 2013; 123:3305-3316
12. Van de Casteele M, Leuckx G, Baeyens L, et al. Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas. Cell Death Dis 2013; 4:e523
13. Xiao X, Chen Z, Shiota C., et al. No evidence for β cell neogenesis in murine adult pancreas. J Clin Invest 2013; 123:2207-2217
14. Bonner-Weir S., Guo L, Li W.C., et al. Islet neogenesis: a possible pathway for beta-cell replenishment. Rev Diabet Stud 2012; 9:407-416
15. Saisho Y, Manesso E, Butler A.E., et al. Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes. Diabetes 2011; 60:848-856
16. Al-Hasani K., Pfeifer A, Courtney M., et al. Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. Dev Cell 2013; 26:86-100
17. Chera S, Baronnier D, Ghila L., et al. Diabetes recovery by age-dependent conversion of pancreatic d-cells into insulin producers. Nature 2014; 514:503-507
18. Collombat P, Xu X, Ravassard P., et al. The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 2009; 138:449-462
19. Dhawan S, Georgia S, Tschen S.I., Fan G., Bhushan A. Pancreatic β cell identity is maintained by DNA methylation-mediated repression of Arx. Dev Cell 2011; 20:419-429
20. Dominguez-Salas P., Cox SE, Prentice A.M., Hennig BJ, Moore SE. Maternal nutritional status, C(1) metabolism and offspring DNA methylation: a review of current evidence in human subjects. Proc Nutr Soc 2012; 71:154-165
21. Westwell-Roper C.Y., Ehses JA, Verchere CB Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction. Diabetes 2014; 63:1698-1711