Arteriosclerotic calcification: A Serpi(n)ginous path to cardiovascular health?

Circulation Research

Volumn 117, Issue 9, 2015, Pages 744-746

  Towler, Dwight A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

alpha 1 antitrypsin; arteriosclerosis; Editorials; matrix Gla protein; serine proteinase inhibitors; Sox2 transcription factor

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; CALCIUM; ELASTASE 1; ELASTASE 2; KALLIKREIN 1; KALLIKREIN 5; KALLIKREIN 6; MESSENGER RNA; OSTEOCALCIN; PROTEINASE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG;

AORTIC TISSUE; ARTERY CALCIFICATION; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR FUNCTION; CELL TRANSDIFFERENTIATION; EDITORIAL; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FOOD AND DRUG ADMINISTRATION; HUMAN; HYPERGLYCEMIA; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEPLETION; PROTEIN EXPRESSION; RNA INTERFERENCE; UPREGULATION; ANIMAL; CALCINOSIS; MESODERM; METABOLISM; VASCULAR ENDOTHELIUM;

ANIMALS; CALCINOSIS; ENDOTHELIUM, VASCULAR; HUMANS; MESODERM; SERINE ENDOPEPTIDASES;

EID: 84943636804     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.307407     Document Type: Editorial

References (22)

1. Fok H, Cruickshank JK, Future treatment of hypertension: shifting the focus from blood pressure lowering to arterial stiffness modulation? Curr Hypertens Rep 2015 17 67. doi: 10.1007/s11906-015-0569-6
2. Soldatos G, Jandeleit-Dahm K, Thomson H, Formosa M, D'orsa K, Calkin AC, Cooper ME, Ahimastos AA, Kingwell BA, Large artery biomechanics and diastolic dysfunctionin patients with Type 2 diabetes. Diabet Med 2011 28 54 60. doi: 10.1111/j.1464-5491.2010.03146.x
3. King KS, Chen KX, Hulsey KM, McColl RW, Weiner MF, Nakonezny PA, Peshock RM, White matter hyperintensities: use of aortic arch pulse wave velocity to predict volume independent of other cardiovascular risk factors. Radiology 2013 267 709 717. doi: 10.1148/radiol.13121598
4. Silbert LC, Dodge HH, Perkins LG, Sherbakov L, Lahna D, Erten-Lyons D, Woltjer R, Shinto L, Kaye JA, Trajectory of white matter hyperintensity burden preceding mild cognitive impairment. Neurology 2012 79 741 747. doi: 10.1212/WNL.0b013e3182661f2b
5. Pase MP, Herbert A, Grima NA, Pipingas A, O'Rourke MF, Arterial stiffness as a cause of cognitive decline and dementia: a systematic review and meta-analysis. Intern Med J 2012 42 808 815. doi: 10.1111/j.1445-5994.2011.02645.x
6. Zeki Al Hazzouri A, Newman AB, Simonsick E, Sink KM, Sutton Tyrrell K, Watson N, Satterfield S, Harris T, Yaffe K, Health ABCS Pulse wave velocity and cognitive decline in elders: the health, aging, and body composition study. Stroke 2013 44 388 393
7. Greenwald SE, Ageing of the conduit arteries. J Pathol 2007 211 157 172. doi: 10.1002/path.2101
8. Cheng SL, Ramachandran B, Behrmann A, Shao JS, Mead M, Smith C, Krchma K, Bello Arredondo Y, Kovacs A, Kapoor K, Brill LM, Perera R, Williams BO, Towler DA, Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals. Circ Res 2015 117 142 156. doi: 10.1161/CIRCRESAHA.117.306712
9. Cheng SL, Behrmann A, Shao JS, Ramachandran B, Krchma K, Bello Arredondo Y, Kovacs A, Mead M, Maxson R, Towler DA, Targeted reduction of vascular Msx1 and Msx2 mitigates arteriosclerotic calcification and aortic stiffness in LDLR-deficient mice fed diabetogenic diets. Diabetes 2014 63 4326 4337. doi: 10.2337/db14-0326
10. Demer LL, Tintut Y, Vascular calcification: pathobiology of a multifaceted disease. Circulation 2008 117 2938 2948. doi: 10.1161/CIRCULATIONAHA.107.743161
11. Yao Y, Jumabay M, Wang A, Boström KI, Matrix Gla protein deficiency causes arteriovenous malformations in mice. J Clin Invest 2011 121 2993 3004. doi: 10.1172/JCI57567
12. Yao Y, Bennett BJ, Wang X, Rosenfeld ME, Giachelli C, Lusis AJ, Boström KI, Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res 2010 107 485 494. doi: 10.1161/CIRCRESAHA.110.219071
13. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G, Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 1997 386 78 81. doi: 10.1038/386078a0
14. Khavandgar Z, Roman H, Li J, Lee S, Vali H, Brinckmann J, Davis EC, Murshed M, Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice. J Bone Miner Res 2014 29 327 337. doi: 10.1002/jbmr.2039
15. Sinha A, Vyavahare NR, High-glucose levels and elastin degradation products accelerate osteogenesis in vascular smooth muscle cells. Diab Vasc Dis Res 2013 10 410 419. doi: 10.1177/1479164113485101
16. Pivin E, Ponte B, Pruijm M, Inactive Matrix Gla-Protein Is Associated With Arterial Stiffness in an Adult Population-Based Study. Hypertension 2015 66 85 92. doi: 10.1161/HYPERTENSIONAHA.115.05177
17. Yao J, Guihard PJ, Blazquez-Medela AM, Guo Y, Moon JH, Jumabay M, Boström KI, Yao Y, Serine protease activation essential for endothelial-mesenchymal transition in vascular calcification. Circ Res 2015 117 758 769. doi: 10.1161/CIRCRESAHA.115.306751
18. Yao Y, Jumabay M, Ly A, Radparvar M, Cubberly MR, Boström KI, A role for the endothelium in vascular calcification. Circ Res 2013 113 495 504. doi: 10.1161/CIRCRESAHA.113.301792
19. Stockley RA, The multiple facets of alpha-1-antitrypsin. Ann Transl Med 2015 3 130. doi: 10.3978/j.issn.2305-5839.2015.04.25
20. Luo LY, Jiang W, Inhibition profiles of human tissue kallikreins by serine protease inhibitors. Biol Chem 2006 387 813 816. doi: 10.1515/BC.2006.103
21. Lose F, Srinivasan S, O'Mara T, Marquart L, Chambers S, Gardiner RA, Aitken JF, Spurdle AB, Batra J, Clements JA, Australian Prostate Cancer BioResource Genetic association of the KLK4 locus with risk of prostate cancer. PLoS One 2012 7 e44520. doi: 10.1371/journal.pone.0044520
22. Inouye M, Ripatti S, Kettunen J, Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. PLoS Genet 2012 8 e1002907. doi: 10.1371/journal.pgen.1002907.