Matrix Gla protein deficiency causes arteriovenous malformations in mice

Journal of Clinical Investigation

Volumn 121, Issue 8, 2011, Pages 2993-3004

  Yao, Yucheng ^a   Jumabay, Medet ^a   Wang, Anthony ^a   Boström, Kristina I ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN RECEPTOR 1; ACTIVIN RECEPTOR 2; BETA ACTIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; CD31 ANTIGEN; EPHRIN B2; MATRIX GLA PROTEIN; PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOVENOUS MALFORMATION; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; EPITHELIUM CELL; GENE DELETION; KIDNEY; LUNG; LUNG BLOOD VESSEL; MATRIX GLA PROTEIN DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VASCULARIZATION;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; ARTERIOVENOUS MALFORMATIONS; BONE MORPHOGENETIC PROTEINS; CALCIUM-BINDING PROTEINS; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; EXTRACELLULAR MATRIX PROTEINS; GENE DELETION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; LUNG; MICE; MICE, INBRED C57BL; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION; TOMOGRAPHY, X-RAY COMPUTED;

EID: 79960998399     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI57567     Document Type: Article

References (40)

1. Zebboudj AF, Imura M, Bostrom K. Matrix GLA protein, a regulatory protein for bone morphogenetic protein-2. J Biol Chem. 2002;277(6):4388-4394. (Pubitemid 34968705)
2. Yao Y, Shahbazian A, Bostrom KI. Proline and gamma-carboxylated glutamate residues in matrix Gla protein are critical for binding of bone morphogenetic protein-4. Circ Res. 2008;102(9):1065-1074. (Pubitemid 351667860)
3. Wallin R, Cain D, Hutson SM, Sane DC, Loeser R. Modulation of the binding of matrix Gla protein (MGP) to bone morphogenetic protein-2 (BMP-2). Thromb Haemost. 2000;84(6):1039-1044. (Pubitemid 32014040)
4. Luo G, et al. Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature. 1997;386(6620):78-81. (Pubitemid 27130923)
5. Speer MY, et al. Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries. Circ Res. 2009;104(6):733-741.
6. Yao Y, Nowak S, Yochelis A, Garfinkel A, Bostrom KI. Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development. J Biol Chem. 2007;282(41):30131-30142. (Pubitemid 350035283)
7. Munroe PB, et al. Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome. Nat Genet. 1999;21(1):142-144. (Pubitemid 29036302)
8. Parmar H, Blaser S, Unger S, Yoo SJ, Papsin B. Petrified ears in a patient with Keutel syndrome: temporal bone CT findings. Pediatr Radiol. 2006;36(3):241-243.
9. David L, Feige JJ, Bailly S. Emerging role of bone morphogenetic proteins in angiogenesis. Cytokine Growth Factor Rev. 2009;20(3):203-212.
10. Govani FS, Shovlin CL. Hereditary haemorrhagic telangiectasia: a clinical and scientific review. Eur J Hum Genet. 2009;17(7):860-871.
11. Urness LD, Sorensen LK, Li DY. Arteriovenous malformations in mice lacking activin receptor-like kinase-1. Nat Genet. 2000;26(3):328-331.
12. Sadick H, Naim R, Gossler U, Hormann K, Riedel F. Angiogenesis in hereditary hemorrhagic telangiectasia: VEGF165 plasma concentration in correlation to the VEGF expression and microvessel density. Int J Mol Med. 2005;15(1):15-19.
13. Sadick H, et al. Does the genotype of HHT patients with mutations of the ENG and ACVRL1 gene correlate to different expression levels of the angiogenic factor VEGF? Int J Mol Med. 2008;22(5):575-580.
14. Shao ES, Lin L, Yao Y, Bostrom KI. Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells. Blood. 2009;114(10):2197-2206.
15. Yao Y, et al. Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res. 2010;107(4):485-494.
16. Murphy PA, et al. Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice. Proc Natl Acad Sci U S A. 2008;105(31):10901-10906.
17. Zhou L, Lim L, Costa RH, Whitsett JA. Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. J Histochem Cytochem. 1996;44(10):1183-1193. (Pubitemid 26337296)
18. Yao Y, Zebboudj AF, Shao E, Perez M, Bostrom K. Regulation of bone morphogenetic protein-4 by matrix GLA protein in vascular endothelial cells involves activin-like kinase receptor 1. J Biol Chem. 2006;281(45):33921-33930. (Pubitemid 46036604)
19. Yao Y, et al. High-density lipoproteins affect endothelial BMP-signaling by modulating expression of the activin-like kinase receptor 1 and 2. Arterioscler Thromb Vasc Biol. 2008;28(12):2266-2274.
20. David L, et al. Bone morphogenetic protein-9 is a circulating vascular quiescence factor. Circ Res. 2008;102(8):914-922. (Pubitemid 351591550)
21. Margraf LR, et al. Cloning and tissue-specific expression of the cDNA for the mouse Clara cell 10 kD protein: comparison of endogenous expression to rabbit uteroglobin promoter-driven transgene expression. Am J Respir Cell Mol Biol. 1993;9(3):231-238.
22. Funaki H, et al. Localization and expression of AQP5 in cornea, serous salivary glands, and pulmonary epithelial cells. Am J Physiol. 1998;275(4 pt 1):C1151-C1157.
23. Simic P, Vukicevic S. Bone morphogenetic proteins in development and homeostasis of kidney. Cytokine Growth Factor Rev. 2005;16(3):299-308. (Pubitemid 40910319)
24. Schrijvers BF, Flyvbjerg A, De Vriese AS. The role of vascular endothelial growth factor (VEGF) in renal pathophysiology. Kidney Int. 2004;65(6):2003-2017. (Pubitemid 38669987)
25. Srinivasan S, et al. A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. Hum Mol Genet. 2003;12(5):473-482. (Pubitemid 36305588)
26. Herve P, et al. Pulmonary vascular disorders in portal hypertension. Eur Respir J. 1998;11(5):1153-1166. (Pubitemid 28281039)
27. Palaniswamy C, Sekhri A, Aronow WS, Kalra A, Peterson SJ. Association of warfarin use with valvular and vascular calcification: a review. Clin Cardiol. 2011;34(2):74-81.
28. Tarif N, et al. Congenital renal arteriovenous malformation presenting as severe hypertension. Nephrol Dial Transplant. 2002;17(2):291-294. (Pubitemid 34157148)
29. Ziani M, et al. Renal arteriovenous malformation requiring surgery in Rendu-Osler-Weber disease (hereditary hemorrhagic telangiectasia). J Urol. 2000;164(4):1292-1293.
30. Di Gennaro L, et al. Asymptomatic microhematuria: an indication of hereditary hemorrhagic telangiectasia? J Urol. 2005;173(1):106-109. (Pubitemid 39627686)
31. Yao Y, et al. Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res. 2010;107(4):485-494.
32. Medici D, et al. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat Med. 2010;16(12):1400-1406.
33. Lee H, et al. Role for peroxisome proliferator-activated receptor alpha in oxidized phospholipidinduced synthesis of monocyte chemotactic protein-1 and interleukin-8 by endothelial cells. Circ Res. 2000;87(6):516-521.
34. Mundel P, et al. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res. 1997;236(1):248-258. (Pubitemid 27452369)
35. Bostrom K, Zebboudj AF, Yao Y, Lin TS, Torres A. Matrix GLA protein stimulates VEGF expression through increased transforming growth factorbeta1 activity in endothelial cells. J Biol Chem. 2004;279(51):52904-52913. (Pubitemid 40051789)
36. Bostrom K, Tsao D, Shen S, Wang Y, Demer LL. Matrix GLA protein modulates differentiation induced by bone morphogenetic protein-2 in C3H10T1/2 cells. J Biol Chem. 2001;276(17):14044-14052.
37. Qiao JH, et al. Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification. Arterioscler Thromb. 1994;14(9):1480-1497.
38. Bostrom KI, Jumabay M, Matveyenko A, Nicholas SB, Yao Y. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Circ Res. 2010;108(4):446-457.
39. Chung AW, et al. Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in human type 2 diabetic arterial vasculature. Circ Res. 2006;99(2):140-148. (Pubitemid 44297037)
40. Piccolo S, Sasai Y, Lu B, De Robertis EM. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell. 1996;86(4):589-598. (Pubitemid 26299490)