메뉴 건너뛰기




Volumn 12, Issue 5, 2015, Pages 6745-6751

Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen-activated protein kinase kinase signaling pathways

Author keywords

Akt; Apoptosis; Breast cancer; Isorhamnetin; Mitogen activated protein kinase kinase

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISORHAMNETIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN BCL 2; 3-METHYLQUERCETIN; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR; PROTEIN KINASE B; QUERCETIN;

EID: 84943620855     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4269     Document Type: Article
Times cited : (65)

References (32)
  • 5
    • 33846869263 scopus 로고    scopus 로고
    • Resistance to endocrine therapy in breast cancer: Exploiting estrogen receptor/growth factor signaling crosstalk
    • Massarweh S and Schiff R: Resistance to endocrine therapy in breast cancer: Exploiting estrogen receptor/growth factor signaling crosstalk. Endocr Relat Cancer 13 (Suppl 1): S15-S24, 2006.
    • (2006) Endocr Relat Cancer , vol.13 , pp. S15-S24
    • Massarweh, S.1    Schiff, R.2
  • 7
    • 68449084678 scopus 로고    scopus 로고
    • Metastatic breast cancer: Therapeutic options according to molecular subtypes and prior adjuvant therapy
    • Guarneri V and Conte P: Metastatic breast cancer: Therapeutic options according to molecular subtypes and prior adjuvant therapy. Oncologist 14: 645-656, 2009.
    • (2009) Oncologist , vol.14 , pp. 645-656
    • Guarneri, V.1    Conte, P.2
  • 8
    • 84867891436 scopus 로고    scopus 로고
    • Targeted agents to reverse resistance to endocrine therapy in metastatic breast cancer: Where are we now and where are we going?
    • Fedele P, Calvani N, Marino A, Orlando L, Schiavone P, Quaranta A and Cinieri S: Targeted agents to reverse resistance to endocrine therapy in metastatic breast cancer: Where are we now and where are we going? Crit Rev Oncol Hematol 84: 243-251, 2012.
    • (2012) Crit Rev Oncol Hematol , vol.84 , pp. 243-251
    • Fedele, P.1    Calvani, N.2    Marino, A.3    Orlando, L.4    Schiavone, P.5    Quaranta, A.6    Cinieri, S.7
  • 9
    • 81755162797 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer
    • Miller TW, Balko JM and Arteaga CL: Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer. J Clin Oncol 29: 4452-4461, 2011.
    • (2011) J Clin Oncol , vol.29 , pp. 4452-4461
    • Miller, T.W.1    Balko, J.M.2    Arteaga, C.L.3
  • 10
    • 18244391514 scopus 로고    scopus 로고
    • Activation of Akt/PKB in breast cancer predicts a worse outcome among endocrine treated patients
    • Perez-Tenorio G and Stal O; Southeast Sweden Breast Cancer Group: Activation of Akt/PKB in breast cancer predicts a worse outcome among endocrine treated patients. Br J Cancer 86: 540-545, 2002.
    • (2002) Br J Cancer , vol.86 , pp. 540-545
    • Southeast Sweden Breast Cancer Group1    Perez-Tenorio, G.2    Stal, O.3
  • 14
    • 0035798683 scopus 로고    scopus 로고
    • Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells
    • Donovan JC, Milic A and Slingerland JM: Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells. J Biol Chem 276: 40888-40895, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 40888-40895
    • Donovan, J.C.1    Milic, A.2    Slingerland, J.M.3
  • 15
    • 0041343273 scopus 로고    scopus 로고
    • Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells
    • Jin W, Wu L, Liang K, Liu B, Lu Y and Fan Z: Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells. Br J Cancer 89: 185-191, 2003.
    • (2003) Br J Cancer , vol.89 , pp. 185-191
    • Jin, W.1    Wu, L.2    Liang, K.3    Liu, B.4    Lu, Y.5    Fan, Z.6
  • 19
    • 79959690712 scopus 로고    scopus 로고
    • Recent advances in understanding the antibacterial properties of flavonoids
    • Cushnie TP and Lamb AJ: Recent advances in understanding the antibacterial properties of flavonoids. Int J Antimicrob Agents 38: 99-107, 2011.
    • (2011) Int J Antimicrob Agents , vol.38 , pp. 99-107
    • Cushnie, T.P.1    Lamb, A.J.2
  • 20
    • 77957592789 scopus 로고    scopus 로고
    • Regulation of survival, proliferation, invasion, angiogenesis and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals
    • Gupta SC, Kim JH, Prasad S and Aggarwal BB: Regulation of survival, proliferation, invasion, angiogenesis and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev 29: 405-434, 2010.
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 405-434
    • Gupta, S.C.1    Kim, J.H.2    Prasad, S.3    Aggarwal, B.B.4
  • 21
    • 33947649459 scopus 로고    scopus 로고
    • The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells
    • Ma G, Yang C, Qu Y, Wei H, Zhang T and Zhang N: The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells. Chem Biol Interact 167: 153-160, 2007.
    • (2007) Chem Biol Interact , vol.167 , pp. 153-160
    • Ma, G.1    Yang, C.2    Qu, Y.3    Wei, H.4    Zhang, T.5    Zhang, N.6
  • 22
    • 33749684014 scopus 로고    scopus 로고
    • Absorption of flavonols derived from sea buckthorn (Hippophae rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans
    • Suomela JP, Ahotupa M, Yang B, Vasankari T and Kallio H: Absorption of flavonols derived from sea buckthorn (Hippophae rhamnoides L.) and their effect on emerging risk factors for cardiovascular disease in humans. J Agric Food Chem 54: 7364-7369, 2006.
    • (2006) J Agric Food Chem , vol.54 , pp. 7364-7369
    • Suomela, J.P.1    Ahotupa, M.2    Yang, B.3    Vasankari, T.4    Kallio, H.5
  • 23
    • 84864559485 scopus 로고    scopus 로고
    • Cellular stress response in Eca-109 cells inhibits apoptosis during early exposure to isorhamnetin
    • Shi C, Fan LY, Cai Z, Liu YY and Yang CL: Cellular stress response in Eca-109 cells inhibits apoptosis during early exposure to isorhamnetin. Neoplasma 59: 361-369, 2012.
    • (2012) Neoplasma , vol.59 , pp. 361-369
    • Shi, C.1    Fan, L.Y.2    Cai, Z.3    Liu, Y.Y.4    Yang, C.L.5
  • 24
    • 84868314521 scopus 로고    scopus 로고
    • Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer
    • Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, et al: Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. J Biol Chem 287: 38028-38040, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 38028-38040
    • Ramachandran, L.1    Manu, K.A.2    Shanmugam, M.K.3    Li, F.4    Siveen, K.S.5    Vali, S.6    Kapoor, S.7    Abbasi, T.8    Surana, R.9    Smoot, D.T.10
  • 25
    • 84865262548 scopus 로고    scopus 로고
    • Isorhamnetin 3-O-robinobioside from Nitraria retusa leaves enhance antioxidant and antigenotoxic activity in human chronic myelogenous leukemia cell line K562
    • Boubaker J, Ben Sghaier M, Skandrani I, Ghedira K and Chekir-Ghedira L: Isorhamnetin 3-O-robinobioside from Nitraria retusa leaves enhance antioxidant and antigenotoxic activity in human chronic myelogenous leukemia cell line K562. BMC Complement Altern Med 12: 135, 2012.
    • (2012) BMC Complement Altern Med , vol.12 , pp. 135
    • Boubaker, J.1    Ben Sghaier, M.2    Skandrani, I.3    Ghedira, K.4    Chekir-Ghedira, L.5
  • 26
    • 80053141767 scopus 로고    scopus 로고
    • Ethyl acetate extract and its major constituent, isorhamnetin 3-O-rutinoside, from Nitraria retusa leaves, promote apoptosis of human myelogenous erythroleukaemia cells
    • Boubaker J, Bhouri W, Ben Sghaier M, Ghedira K, Dijoux Franca MG and Chekir-Ghedira L: Ethyl acetate extract and its major constituent, isorhamnetin 3-O-rutinoside, from Nitraria retusa leaves, promote apoptosis of human myelogenous erythroleukaemia cells. Cell Prolif 44: 453-461, 2011.
    • (2011) Cell Prolif , vol.44 , pp. 453-461
    • Boubaker, J.1    Bhouri, W.2    Ben Sghaier, M.3    Ghedira, K.4    Dijoux Franca, M.G.5    Chekir-Ghedira, L.6
  • 30
    • 84893869559 scopus 로고    scopus 로고
    • Isorhamnetin suppresses colon cancer cell growth through the PI3K-Akt-m TOR pathway
    • Li C, Yang X, Chen C, Cai S and Hu J: Isorhamnetin suppresses colon cancer cell growth through the PI3K-Akt-m TOR pathway. Mol Med Rep 9: 935-940, 2014.
    • (2014) Mol Med Rep , vol.9 , pp. 935-940
    • Li, C.1    Yang, X.2    Chen, C.3    Cai, S.4    Hu, J.5
  • 31
    • 0004580398 scopus 로고    scopus 로고
    • Flavonoids: Old and new aspects of a class of natural therapeutic drugs
    • Di Carlo G, Mascolo N, Izzo AA and Capasso F: Flavonoids: Old and new aspects of a class of natural therapeutic drugs. Life Sci 65: 337-353, 1999.
    • (1999) Life Sci , vol.65 , pp. 337-353
    • Di Carlo, G.1    Mascolo, N.2    Izzo, A.A.3    Capasso, F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.