Catalpol suppresses proliferation and facilitates apoptosis of MCF-7 breast cancer cells through upregulating microRNA-146a and downregulating matrix metalloproteinase-16 expression

Molecular Medicine Reports

Volumn 12, Issue 5, 2015, Pages 7609-7614

  Liu, Chuan ^a   Wu, Fan ^b   Liu, Yuanwei ^c   Meng, Cong ^c  

^a BINZHOU MEDICAL UNIVERSITY   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c QINGDAO UNIVERSITY   (China)

Author keywords

Apoptosis; Breast cancer; Catalpol; Matrix metalloproteinase 16; MicroRNA 146a; Proliferation

Indexed keywords

CATALPOL; MATRIX METALLOPROTEINASE 16; MICRORNA 146A; ANTINEOPLASTIC AGENT; IRIDOID; MICRORNA; MIRN146 MICRORNA, HUMAN;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; MCF 7 CELL LINE; PROTEIN EXPRESSION; UPREGULATION; BREAST; BREAST NEOPLASMS; CELL PROLIFERATION; CHEMISTRY; DOWN REGULATION; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; REHMANNIA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST; BREAST NEOPLASMS; CELL PROLIFERATION; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IRIDOID GLUCOSIDES; MATRIX METALLOPROTEINASE 16; MCF-7 CELLS; MICRORNAS; REHMANNIA; UP-REGULATION;

EID: 84943619285     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4361     Document Type: Article

References (36)

1. Hu XC, Zhang J, Xu BH, et al: Cisplatin plus gemcitabine versus paclitaxel plus gemcitabine as first-line therapy for metastatic triple-negative breast cancer (CBCSG006): A randomised, open-label, multicentre, phase 3 trial. Lancet Oncol 16: 436-446, 2015.
2. Fu JF, Chen HL, Yang J, Yi CH and Zheng S: Feasibility and accuracy of sentinel lymph node biopsy in clinically node-positive breast cancer after neoadjuvant chemotherapy: A meta-analysis. PLoS One 9: e105316, 2014.
3. Nie XC, Dong DS, Bai Y and Xia P: Meta-analysis of black tea consumption and breast cancer risk: Update 2013. Nutr Cancer 66: 1009-1014, 2014.
4. Noh EM, Chung EY, Youn HJ, Jung SH, Hur H, Lee YR and Kim JS: Cis-guggulsterone inhibits the IKK/NF-κB pathway, whereas trans-guggulsterone inhibits MAPK/AP-1 in MCF-7 breast cancer cells: Guggulsterone regulates MMP-9 expression in an isomer-specific manner. Int J Mol Med 31: 393-399, 2013.
5. Cai KQ, Yang WL, Capo-Chichi CD, Vanderveer L, Wu H, Godwin AK and Xu XX: Prominent expression of metalloproteinases in early stages of ovarian tumorigenesis. Mol Carcinog 46: 130-143, 2007.
6. Fan SH, Wang YY, Lu J, et al: CERS2 Suppresses Tumor Cell Invasion and Is Associated with Decreased V-ATPase and MMP-2/MMP-9 activities in Breast Cancer. J Cell Biochem 116: 502-513, 2015.
7. Xie M, Hu A, Luo Y, Sun W, Hu X and Tang S: Interleukin-4 and melatonin ameliorate high glucose and interleukin-1beta stimulated inflammatory reaction in human retinal endothelial cells and retinal pigment epithelial cells. Mol Vis 20: 921-928, 2014.
8. Tang C, Chen L, Gu W, et al: Cyclosporin A enhances the ability of trophoblasts to displace the activated human umbilical vein endothelial cell monolayers. Int J Clin Exp Pathol 6: 2441-2450, 2013.
9. Delassus GS, Cho H, Park J and Eliceiri GL: New pathway links from cancer-progression determinants to gene expression of matrix metalloproteinases in breast cancer cells. J Cell Physiol 217: 739-744, 2008.
10. Hegedüs L, Cho H, Xie X and Eliceiri GL: Additional MDA-MB-231 breast cancer cell matrix metalloproteinases promote invasiveness. J Cell Physiol 216: 480-485, 2008.
11. Lee RC, Feinbaum RL and Ambros V: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854, 1993.
12. Hede K: Studies define role of microRNA in cancer. J Natl Cancer Inst 97: 1114-1115, 2005.
13. Croce CM and Calin GA: miRNAs, cancer, and stem cell division. Cell 122: 6-7, 2005.
14. Gregory RI and Shiekhattar R: MicroRNA biogenesis and cancer. Cancer Res 65: 3509-3512, 2005.
15. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J and Benz CC: Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 27: 5643-5647, 2008.
16. Kumar S, Keerthana R, Pazhanimuthu A and Perumal P: Overexpression of circulating miRNA-21 and miRNA-146a in plasma samples of breast cancer patients. Indian J Biochem Biophys 50: 210-214, 2013.
17. Xiao WQ, Yin GJ, Fan YT, Qiu L, Cang XF, Yu G, Hu YL, Xing M, Wu Q, Wang XP, et al: Catalpol ameliorates sodium taurocholate-induced acute pancreatitis in rats via inhibiting activation of nuclear factor kappa B. Int J Mol Sci 15: 11957-11972, 2014.
18. Huang WJ, Niu HS, Lin MH, Cheng JT and Hsu FL: Antihyperglycemic effect of catalpol in streptozotocin-induced diabetic rats. J Nat Prod 73: 1170-1172, 2010.
19. Lü J, Wang Y, Zhao W, Li N, Li H, Lu J, Zeng W, Bao S and Bai Y: Effects of catalpol, L-shikonin and paeonol extracted from radix rehmanniae, radix arnebiae and cortex moutan on KGF-induced HaCaT cell proliferation. Zhonghua Yi Xue Za Zhi 94: 1265-1269, 2014 (In Chinese).
20. García C, León LG, Pungitore CR, Ríos-Luci C, Daranas AH, Montero JC, Pandiella A, Tonn CE, Martín VS and Padrón JM: Enhancement of antiproliferative activity by molecular simplification of catalpol. Bioorg Med Chem 18: 2515-2523, 2010.
21. Chen C, Chen Z, Xu F, Zhu C, Fang F, Shu S, Li M and Ling C: Radio-protective effect of catalpol in cultured cells and mice. J Radiat Res (Tokyo) 54: 76-82, 2013.
22. Pogribny IP, Filkowski JN, Tryndyak VP, Golubov A, Shpyleva SI and Kovalchuk O: Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. Int J Cancer 127: 1785-1794, 2010.
23. Pungitore CR, León LG, García C, Martín VS, Tonn CE and Padrón JM: Novel antiproliferative analogs of the Taq DNA polymerase inhibitor catalpol. Bioorg Med Chem Lett 17: 1332-1335, 2007.
24. Wang Z, An LJ, Duan YL, Li YC and Jiang B: Catalpol protects rat pheochromocytoma cells against oxygen and glucose deprivation-induced injury. Neurol Res 30: 106-112, 2008.
25. Liang JH, Du J, Xu LD, Jiang T, Hao S, Bi J and Jiang B: Catalpol protects primary cultured cortical neurons induced by Abeta(1-42) through a mitochondrial-dependent caspase pathway. Neurochem Int 55: 741-746, 2009.
26. Loo WT, Chen JP, Chow LW and Chou JW: Effects of Shugansanjie Tang on matrix metalloproteinases 1, 3 and 9 and telomerase reverse transcriptase expression in human breast cells in vitro. Biomed Pharmacother 61: 601-605, 2007.
27. Fagan-Solis KD, Schneider SS, Pentecost BT, Bentley BA, Otis CN, Gierthy JF and Arcaro KF: The RhoA pathway mediates MMP-2 and MMP-9-independent invasive behavior in a triple-negative breast cancer cell line. J Cell Biochem 114: 1385-1394, 2013.
28. Liu YF, Zhao Y, Wen XS and Dong QT: Advances in research on pharmacodynamics and chemical conversion of catalpol. Zhongguo Zhong Yao Za Zhi 32: 1128-1130, 2007 (In Chinese).
29. Saracoglu I and Harput US: In vitro cytotoxic activity and structure activity relationships of iridoid glucosides derived from Veronica species. Phytother Res 26: 148-152, 2012.
30. Adams BD, Kasinski AL and Slack FJ: Aberrant regulation and function of microRNAs in cancer. Curr Biol 24: R762-R776, 2014.
31. Maxwell GL, Shoji Y, Darcy K, et al: MicroRNAs in endometrial cancers from black and white patients. Am J Obstet Gynecol 212: e191-e110, 2015.
32. Seven M, Karatas OF, Duz MB and Ozen M: The role of miRNAs in cancer: from pathogenesis to therapeutic implications. Future Oncol 10: 1027-1048, 2014.
33. D'Ippolito E and Iorio MV: MicroRNAs and triple negative breast cancer. Int J Mol Sci 14: 22202-22220, 2013.
34. Zhou Y, Hu Y, Yang M, Jat P, Li K, Lombardo Y, Xiong D, Coombes RC, Raguz S and Yagüe E: The miR-106b~25 cluster promotes bypass of doxorubicin-induced senescence and increase in motility and invasion by targeting the E-cadherin transcriptional activator EP300. Cell Death Differ 21: 462-474, 2014.
35. Sandhu R, Rein J, D'Arcy M, Herschkowitz JI, Hoadley KA and Troester MA: Overexpression of miR-146a in basal-like breast cancer cells confers enhanced tumorigenic potential in association with altered p53 status. Carcinogenesis 35: 2567-2575, 2014.
36. Wang D, Liu D, Gao J, Liu M, Liu S, Jiang M, Liu Y and Zheng D: TRAIL-induced miR-146a expression suppresses CXCR4-mediated human breast cancer migration. FEBS J 280: 3340-3353, 2013.