Cyclosporin A enhances the ability of trophoblasts to displace the activated human umbilical vein endothelial cell monolayers

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 11, 2013, Pages 2441-2450

  Tang, Chuanling ^a   Chen, Limei ^a   Gu, Weirong ^a   Du, Meirong ^a   Li, Mingqing ^a   Chen, Qi ^a,b   Li, Dajin ^a  

^a FUDAN UNIVERSITY   (China)

^b THE UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Activation; CsA; HUVEC; Invasion; Remodelling; Trophoblast

Indexed keywords

CADHERIN; CDH1 PROTEIN, HUMAN; CONNECTIN; CXCL12 PROTEIN, HUMAN; CYCLOSPORIN; GELATINASE A; GELATINASE B; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN; STROMAL CELL DERIVED FACTOR 1; TTN PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA;

ACTIVATION; ARTICLE; CELL ADHESION; CELL MOTION; COCULTURE; CSA; DRUG EFFECT; FEMALE; HUMAN; HUVEC; INVASION; METABOLISM; NECROSIS; PATHOLOGY; PREGNANCY; REMODELLING; REPRODUCTION; SIGNAL TRANSDUCTION; TROPHOBLAST; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

ACTIVATION; CSA; HUVEC; INVASION; REMODELLING; TROPHOBLAST;

CADHERINS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CHEMOKINE CXCL12; COCULTURE TECHNIQUES; CONNECTIN; CYCLOSPORINE; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NECROSIS; PLACENTATION; PREGNANCY; SIGNAL TRANSDUCTION; TROPHOBLASTS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84887125692     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Harris LK. Trophoblast-vascular cell interactions in early pregnancy:how to remodel a vessel. Placenta 2010;31:S93-S98.
2. Huppertz B, Peeters LL. Vascular biology in implantation and placentation. Angiogenesis 2005;8:157-167.
3. Ball E, Bulmer JN, Ayis S, Lyall F, Robson SC. Late sporadic miscarriage is associated with abnormalities in spiral artery transformation and trophoblast invasion. J Pathol 2006;208:535-542.
4. Kadyrov M, Schmitz C, Black S, Kaufmann P, Huppertz B. Pre-eclampsia and maternal anaemia display reduced apoptosis and opposite invasive phenotypes of extravillous trophoblast. Placenta 2003;24:540-548.
5. Kim YM, Bujold E, Chaiworapongsa T, Gomez R, Yoon BH, Thaler HT, Rotmensch S, Romero R. Failure of physiologic transformation of the spiral arteries in patients with preterm labor and intact membranes. Am J Obstet Gynecol 2003;189:1063-1069.
6. Khong TY, De Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol 1986;93:1049-1059.
7. Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 2008;359:61-73.
8. Moster D, Lie RT, Markestad T. Long-term medical and social consequences of preterm birth. N Engl J Med 2008;359:262-273.
9. Barker DJ, Martyn CN, Osmond C, Hales CN, Fall CH. Growth in utero and serum cholesterol concentrations in adult life. BMJ 1993;307:1524-1527.
10. Bach JF. The contribution of cyclosporine A to the understanding and treatment of autoimmune diseases. Transplant Proc 1999;31:16S-18S.
11. Du MR, Dong L, Zhou WH, Yan FT, Li DJ. Cyclosporin a improves pregnancy outcome by promoting functions of trophoblasts and inducing maternal tolerance to the allogeneic fetus in abortion-prone matings in the mouse. Bilo Reprone 2007;76:906-914.
12. 2+/calcineurin/NFAT signaling pathways. Biol Reprod 2008;78:1102-1110.
13. Tang CL, Zhao HB, Li MQ, Du MR, Meng YH, Li DJ. Focal adhesion kinase signaling is necessary for the cyclosporin A-enhanced migration and invasion of human trophoblast cells. Placenta 2012;33:704-711.
14. Chen Q, Stone PR, McCowan LM, Chamley LW. Activated endothelial cells resist displacement by trophoblast in vitro. Placenta 2007;28:743-747.
15. Baudin B, Bruneel A, Bosselut N, Vaubourdolle M. A protocol for isolation and culture of human umbilical vein endothelial cells. Nat Protoc 2007;2:481-485.
16. Fadok VA, Bratton DL, Guthrie L, Henson PM. Differential effects of apoptotic versus lysed cells on macrophage production of cytokines:role of proteases. J Immunol 2001;166:6847-6854.
17. Hung TH, Charnock-Jones DS, Skepper JN, Burton GJ. Secretion of tumor necrosis factor-alpha from human placental tissues induced by hypoxia-reoxygenation causes endothelial cell activation in vitro:a potential mediator of the inflammatory response in preeclampsia. Am J Pathol 2004;164:1049-1061.
18. Toth M, Fridman R. Assessment of Gelatinases (MMP-2 and MMP-9) by Gelatin Zymography. Methods Mol Med 2001;57:163-174.
19. Kockx M, Jessup W, Kritharides L. Cyclosporin A and atherosclerosis--cellular pathways in atherogenesis. Pharmacol Ther 2010;128:106-118.
20. Hojo M, Morimoto T, Maluccio M, Asano T, Morimoto K, Lagman M, Shimbo T, Suthanthiran M. Cyclosporine induces cancer progression by a cell-autonomous mechanism. Nature 1999;397:530-534.
21. Walsh SB, Xu J, Xu H, Kurundkar AR, Maheswari A, Grizzle WE, Timares L, Huang CC, Kopelovich L, Elmets CA, Athar M. Cyclosporine A mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition:Role of TGFß signaling pathway. Mol Carcinog 2011;50:516-527.
22. Zhou P, Luo X, Qi HB, Zong WJ, Zhang H, Liu DD, Li QS. The expression of pentraxin 3 and tumor necrosis factor-alpha is increased in preeclamptic placental tissue and maternal serum. Inflamm Res 2012;61:1005-1012.
23. Chen JZ, Sheehan PM, Brennecke SP, Keogh RJ. Vessel remodelling, pregnancy hormones and extravillous trophoblast function. Mol Cell Endocrinol 2012;349:138-144.
24. Knöfler M. Critical growth factors and signalling pathways controlling human trophoblast invasion. Int J Dev Biol 2010;54:269-280.
25. Rosario GX, Konno T, Soares MJ. Maternal hypoxia activates endovascular trophoblast cell invasion. Dev Biol 2008;314:362-375.
26. May SR, Stewart NJ, Chang W, Peterson AS. A Titin mutation defines roles for circulation in endothelial morphogenesis. Dev Biol 2004;270:31-46.
27. Perez-Moreno M, Jamora C, Fuchs E. Sticky business:orchestrating cellular signals at adherens junctions. Cell 2003;112:535-548.
28. Shih IeM, Hsu MY, Oldt RJ 3rd, Herlyn M, Gearhart JD, Kurman RJ. The role of E-cadherin in the motility and invasion of implantation site intermediate trophoblast. Placenta 2002;23:706-15.
29. Arimoto-Ishida E, Sakata M, Sawada K, Nakayama M, Nishimoto F, Mabuchi S, Takeda T, Yamamoto T, Isobe A, Okamoto Y, Lengyel E, Suehara N, Morishige K, Kimura T. Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation. Endocrinology 2009;150:4306-4315.
30. Staun-Ram E, Goldman S, Gabarin D, Shalev E. Expression and importance of matrix metalloproteinase 2 and 9 (MMP-2 and -9) in human trophoblast invasion. Reprod Biol Endocrinol 2004;2:59.
31. Neuhaus T, Stier S, Totzke G, Gruenewald E, Fronhoff S, Sachinidis A, Vetter H, Ko YD. Stromal cell-derived factor 1alpha (SDF-1alpha) induces gene-expression of early growth response-1 (Egr-1) and VEGF in human arterial endothelial cells and enhances VEGF induced cell proliferation. Cell Prolif 2003;36:75-86.
32. Wu X, Li DJ, Yuan MM, Zhu Y, Wang MY. The expression of CXCR4/CXCL12 in first-trimester human trophoblast cells. Biol Reprod 2004;70:1877-1885.