Companion animals: Translational scientist's new best friends

Science Translational Medicine

Volumn 7, Issue 308, 2015, Pages

  Kol, Amir ^a   Arzi, Boaz ^a   Athanasiou, Kyriacos A ^b,c   Farmer, Diana L ^c   Nolta, Jan A ^c   Rebhun, Robert B ^a   Chen, Xinbin ^a,c   Griffiths, Leigh G ^a   Verstraete, Frank J M ^a   Murphy, Christopher J ^a,c   Borjesson, Dori L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Davis   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; CYTOKINE; IBRUTINIB; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2;

ARTICLE; BONE REGENERATION; CARTILAGE CELL; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL TRIAL (TOPIC); DEVICE APPROVAL; DRUG EFFICACY; DRUG RESPONSE; FOOD AND DRUG ADMINISTRATION; GENE EXPRESSION; GENETIC DISORDER; GENETIC PREDISPOSITION; GENOTYPE; HUMAN; IMMUNE RESPONSE; KERATOCONJUNCTIVITIS SICCA; MANDIBLE RECONSTRUCTION; MANTLE CELL LYMPHOMA; MEDICAL RESEARCH; MESENCHYMAL STEM CELL; NEOPLASM; NONHUMAN; OSTEOARTHRITIS; PHENOTYPE; PREDICTIVE VALUE; PRIORITY JOURNAL; SPINAL CORD INJURY; TRANSLATIONAL RESEARCH; UNITED STATES; VETERINARY MEDICINE; ANIMAL; DISEASE MODEL;

ANIMALS; CLINICAL TRIALS AS TOPIC; DISEASE MODELS, ANIMAL; HUMANS; TRANSLATIONAL MEDICAL RESEARCH;

EID: 84943619071     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aaa9116     Document Type: Article

References (65)

1. H. B. Van Der Worp, D. W. Howells, E. S. Sena, M. J. Porritt, S. Rewell, V. O'Collins, M. R. Macleod, Can animal models of disease reliably inform human studies? PLOS Med. 7, e1000245 (2010).
2. S. Lin, Y. Lin, J. R. Nery, M. A. Urich, A. Breschi, C. A. Davis, A. Dobin, C. Zaleski, M. A. Beer, W. C. Chapman, T. R. Gingeras, J. R. Ecker, M. P. Snyder, Comparison of the transcriptional landscapes between human and mouse tissues. Proc. Natl. Acad. Sci. U. S. A. 111, 17224-17229 (2014).
3. M. Hay, D. W. Thomas, J. L. Craighead, C. Economides, J. Rosenthal, Clinical development success rates for investigational drugs. Nat. Biotechnol. 32, 40-51 (2014).
4. Code of Federal Regulations - Title 21 - Food and Drugs. 312.23 (a) (8) (2015). www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfCFR/CFRSearch.cfm?fr=312.23.
5. Guidance for industry: Preclinical assessment of investigational cellular and gene therapy products (FDA, Center for Biologics Evaluation and Research, Washington, DC, 2013).
6. A. Krogh, The Progress of Physiology. Science 70, 200-204 (1929).
7. M. Paoloni, C. Khanna, Translation of new cancer treatments from pet dogs to humans. Nat. Rev. Cancer 8, 147-156 (2008).
8. M. M. Christopher, One health, one literature: Weaving together veterinary and medical research. Sci. Transl. Med. 7, 303fs36 (2015).
9. H. G. Parker, L. V. Kim, N. B. Sutter, S. Carlson, T. D. Lorentzen, T. B. Malek, G. S. Johnson, H. B. DeFrance, E. A. Ostrander, L. Kruglyak, Genetic structure of the purebred domestic dog. Science 304, 1160-1164 (2004).
10. C. M. Wade, E. Giulotto, S. Sigurdsson, M. Zoli, S. Gnerre, F. Imsland, T. L. Lear, D. L. Adelson, E. Bailey, R. R. Bellone, H. Blöcker, O. Distl, R. C. Edgar, M. Garber, T. Leeb, E. Mauceli, J. N. MacLeod, M. C. Penedo, J. M. Raison, T. Sharpe, J. Vogel, L. Andersson, D. F. Antczak, T. Biagi, M. M. Binns, B. P. Chowdhary, S. J. Coleman, G. Della Valle, S. Fryc, G. Guérin, T. Hasegawa, E. W. Hill, J. Jurka, A. Kiialainen, G. Lindgren, J. Liu, E. Magnani, J. R. Mickelson, J. Murray, S. G. Nergadze, R. Onofrio, S. Pedroni, M. F. Piras, T. Raudsepp, M. Rocchi, K. H. Røed, O. A. Ryder, S. Searle, L. Skow, J. E. Swinburne, A. C. Syvänen, T. Tozaki, S. J. Valberg, M. Vaudin, J. R. White, M. C. Zody, Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, E. S. Lander, K. Lindblad-Toh, Genome sequence, comparative analysis, and population genetics of the domestic horse. Science 326, 865-867 (2009).
11. G. Tamazian, S. Simonov, P. Dobrynin, A. Makunin, A. Logachev, A. Komissarov, A. Shevchenko, V. Brukhin, N. Cherkasov, A. Svitin, K. P. Koepfli, J. Pontius, C. A. Driscoll, K. Blackistone, C. Barr, D. Goldman, A. Antunes, J. Quilez, B. Lorente-Galdos, C. Alkan, T. Marques-Bonet, M. Menotti-Raymond, V. A. David, K. Narfström, S. J. O'Brien, Annotated features of domestic cat - Felis catus genome. GigaScience 3, 13-15 (2014).
12. C. E. Alvarez, Naturally occurring cancers in dogs: Insights for translational genetics and medicine. ILAR J. 55, 16-45 (2014).
13. E. P. Murchison, D. C. Wedge, L. B. Alexandrov, B. Fu, I. Martincorena, Z. Ning, J. M. Tubio, E. I. Werner, J. Allen, A. B. De Nardi, E. M. Donelan, G. Marino, A. Fassati, P. J. Campbell, F. Yang, A. Burt, R. A. Weiss, M. R. Stratton, Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage. Science 343, 437-440 (2014).
14. C. A. Rebbeck, A. M. Leroi, A. Burt, Mitochondrial capture by a transmissible cancer. Science 331, 303 (2011).
15. D. Dingli, M. A. Nowak, Cancer biology: Infectious tumour cells. Nature 443, 35-36 (2006).
16. N. Chanda, A. Upendran, E. J. Boote, A. Zambre, S. Axiak, K. Selting, K. V. Katti, W. M. Leevy, Z. Afrasiabi, J. Vimal, J. Singh, J. C. Lattimer, R. Kannan, Gold nanoparticle based X-ray contrast agent for tumor imaging in mice and dog: A potential nano-platform for computer tomography theranostics. J. Biomed. Nanotechnol. 10, 383-392 (2014).
17. M. Paoloni, C. Webb, C. Mazcko, D. Cherba, W. Hendricks, S. Lana, E. J. Ehrhart, B. Charles, H. Fehling, L. Kumar, D. Vail, M. Henson, M. Childress, B. Kitchell, C. Kingsley, S. Kim, M. Neff, B. Davis, C. Khanna, J. Trent, Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials. PLOS ONE 9, e90028 (2014).
18. L. A. Honigberg, A. M. Smith, M. Sirisawad, E. Verner, D. Loury, B. Chang, S. Li, Z. Pan, D. H. Thamm, R. A. Miller, J. J. Buggy, The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc. Natl. Acad. Sci. U. S. A. 107, 13075-13080 (2010).
19. N. J. Roberts, L. Zhang, F. Janku, A. Collins, R.-Y. Bai, V. Staedtke, A. W. Rusk, D. Tung, M. Miller, J. Roix, K. V. Khanna, R. Murthy, R. S. Benjamin, T. Helgason, A. D. Szvalb, J. E. Bird, S. Roy-Chowdhuri, H. H. Zhang, Y. Qiao, B. Karim, J. McDaniel, A. Elpiner, A. Sahora, J. Lachowicz, B. Phillips, A. Turner, M. K. Klein, G. Post, L. A. Diaz Jr., G. J. Riggins, N. Papadopoulos, K. W. Kinzler, B. Vogelstein, C. Bettegowda, D. L. Huso, M. Varterasian, S. Saha, S. Zhou, Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses. Sci. Transl. Med. 6, 249ra111 (2014).
20. R. C. Lawrence, D. T. Felson, C. G. Helmick, L. M. Arnold, H. Choi, R. A. Deyo, S. Gabriel, R. Hirsch, M. C. Hochberg, G. G. Hunder, J. M. Jordan, J. N. Katz, H. M. Kremers, F. Wolfe, National Arthritis Data Workgroup, Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 58, 26-35 (2008).
21. D. J. Huey, J. C. Hu, K. A. Athanasiou, Unlike bone, cartilage regeneration remains elusive. Science 338, 917-921 (2012).
22. S. Sutton, A. Clutterbuck, P. Harris, T. Gent, S. Freeman, N. Foster, R. Barrett-Jolley, A. Mobasheri, The contribution of the synovium, synovial derived inflammatory cytokines and neuropeptides to the pathogenesis of osteoarthritis. Vet. J. 179, 10-24 (2009).
23. B. Arzi, E. R. Wisner, D. J. Huey, P. H. Kass, J. Hu, K. A. Athanasiou, A proposed model of naturally occurring osteoarthritis in the domestic rabbit. Lab Anim. (NY) 41, 20-25 (2012).
24. S. Arnhold, S. Wenisch, Adipose tissue derived mesenchymal stem cells for musculoskeletal repair in veterinary medicine. American journal of stem cells 4, 1-12 (2015).
25. M. J. Peffers, P. I. Milner, S. R. Tew, P. D. Clegg, Regulation of SOX9 in normal and osteoarthritic equine articular chondrocytes by hyperosmotic loading. Osteoarthritis Cartilage 18, 1502-1508 (2010).
26. B. H. Dobkin, Curiosity and cure: Translational research strategies for neural repair-mediated rehabilitation. Dev. Neurobiol. 67, 1133-1147 (2007).
27. J. M. Levine, G. J. Levine, B. F. Porter, K. Topp, L. J. Noble-Haeusslein, Naturally occurring disk herniation in dogs: An opportunity for pre-clinical spinal cord injury research. J. Neurotrauma 28, 675-688 (2011).
28. N. Safra, A. G. Bassuk, P. J. Ferguson, M. Aguilar, R. L. Coulson, N. Thomas, P. L. Hitchens, P. J. Dickinson, K. M. Vernau, Z. T. Wolf, D. L. Bannasch, Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans. PLOS Genet. 9, e1003646 (2013).
29. D. B. Cox, R. J. Platt, F. Zhang, Therapeutic genome editing: Prospects and challenges. Nat. Med. 21, 121-131 (2015).
30. F. Mantelli, M. Massaro-Giordano, I. Macchi, A. Lambiase, S. Bonini, The cellular mechanisms of dry eye: From pathogenesis to treatment. J. Cell. Physiol. 228, 2253-2256 (2013).
31. C. J. Murphy, E. Bentley, P. E. Miller, K. McIntyre, G. Leatherberry, R. Dubielzig, E. Giuliano, C. P. Moore, T. E. Phillips, P. B. Smith, E. Prescott, J. M. Miller, P. Thomas, R. Scagliotti, D. Esson, T. Gadek, C. A. O'Neill, The pharmacologic assessment of a novel lymphocyte function-associated antigen-1 antagonist (SAR 1118) for the treatment of keratoconjunctivitis sicca in dogs. Invest. Ophthalmol. Vis. Sci. 52, 3174-3180 (2011).
32. R. L. Kaswan, M. A. Salisbury, D. A. Ward, Spontaneous canine keratoconjunctivitis sicca. A useful model for human keratoconjunctivitis sicca: Treatment with cyclosporine eye drops. Arch. Ophthalmol. 107, 1210-1216 (1989).
33. S. M. LaRue, S. J. Withrow, B. E. Powers, R. H. Wrigley, E. L. Gillette, P. D. Schwarz, R. C. Straw, S. L. Richter, Limbsparing treatment for osteosarcoma in dogs. J. Am. Vet. Med. Assoc. 195, 1734-1744 (1989).
34. S. J. Withrow, D. E. Thrall, R. C. Straw, B. E. Powers, R. H. Wrigley, S. M. Larue, R. L. Page, D. C. Richardson, K. W. Bissonette, C. W. Betts, D. J. Deyoung, S. L. Richter, V. J. Jameson, S. L. George, R. Dodge, E. L. Gillette, E. B. Douple, Intra-arterial cisplatin with or without radiation in limbsparing for canine osteosarcoma. Cancer 71, 2484-2490 (1993).
35. B. Arzi, F. J. Verstraete, D. J. Huey, D. D. Cissell, K. A. Athanasiou, Regenerating mandibular bone using rhBMP-2: Part 1. Immediate reconstruction of segmental mandibulectomies. Vet. Surg. 44, 403-409 (2015).
36. F. J. Verstraete, B. Arzi, D. J. Huey, D. D. Cissell, K. A. Athanasiou, Regenerating mandibular bone using rhBMP-2: Part 2. Treatment of chronic, defect Non-union fractures. Vet. Surg. 44, 410-416 (2015).
37. R. Chinnadurai, S. Ng, V. Velu, J. Galipeau, Challenges in animal modelling of mesenchymal stromal cell therapy for inflammatory bowel disease. World J. Gastroenterol. 21, 4779-4787 (2015).
38. E. De Bakker, B. Van Ryssen, C. De Schauwer, E. Meyer, Canine mesenchymal stem cells: State of the art, perspectives as therapy for dogs and as a model for man. Vet. Q. 33, 225-233 (2013).
39. N. G. Singer, A. I. Caplan, Mesenchymal stem cells: Mechanisms of inflammation. Annu. Rev. Pathol. 6, 457-478 (2011).
40. B. Arzi, A. Kol, B. Murphy, N. J. Walker, J. A. Wood, K. Clark, F. J. Verstraete, D. L. Borjesson, Feline foamy virus adversely affects feline mesenchymal stem cell culture and expansion: Implications for animal model development. Stem Cells Dev. 24, 814-823 (2015).
41. B. Arzi, B. Murphy, D. P. Cox, N. Vapniarsky, P. H. Kass, F. J. Verstraete, Presence and quantification of mast cells in the gingiva of cats with tooth resorption, periodontitis and chronic stomatitis. Arch. Oral Biol. 55, 148-154 (2010).
42. C. R. Burtner, B. C. Beard, D. R. Kennedy, M. E. Wohlfahrt, J. E. Adair, G. D. Trobridge, A. M. Scharenberg, T. R. Torgerson, D. J. Rawlings, P. J. Felsburg, H. P. Kiem, Intravenous injection of a foamy virus vector to correct canine SCIDX1. Blood 123, 3578-3584 (2014).
43. C. Hinderer, P. Bell, B. L. Gurda, Q. Wang, J. P. Louboutin, Y. Zhu, J. Bagel, P. O'Donnell, T. Sikora, T. Ruane, P. Wang, M. E. Haskins, J. M. Wilson, Liver-directed gene therapy corrects cardiovascular lesions in feline mucopolysaccharidosis type I. Proc. Natl. Acad. Sci. U. S. A. 111, 14894-14899 (2014).
44. P. R. Fox, C. Basso, G. Thiene, B. J. Maron, Spontaneously occurring restrictive nonhypertrophied cardiomyopathy in domestic cats: A new animal model of human disease. Cardiovasc. Pathol. 23, 28-34 (2014).
45. C. Hyun, L. J. Filippich, Molecular genetics of sudden cardiac death in small animals: A review. Vet. J. 171, 39-50 (2006).
46. C. D. Hariu, D. H. Carpenter Jr., Arrhythmogenic right ventricular cardiomyopathy in boxers. Compend Contin. Educ. Vet. 32, E3 (2010).
47. S. Simpson, J. Edwards, R. D. Emes, M. A. Cobb, N. P. Mongan, C. S. Rutland, A predictive model for canine dilated cardiomyopathy: A meta-analysis of Doberman Pinscher data. Peer J. 3, e842 (2015).
48. K. J. Freise, T. L. Lin, T. M. Fan, V. Recta, T. P. Clark, Evidencebased medicine: The design and interpretation of noninferiority clinical trials in veterinary medicine. J. Vet. Intern. Med. 27, 1305-1317 (2013).
49. L. Toews, The information infrastructure that supports evidence-based veterinary medicine: A comparison with human medicine. J. Vet. Med. Educ. 38, 123-134 (2011).
50. L. Dalgaard, Comparison of minipig, dog, monkey and human drug metabolism and disposition. J. Pharmacol. Toxicol. Methods 74, 80-92 (2015).
51. D. M. Vail, D. H. Thamm, H. Reiser, A. S. Ray, G. H. Wolfgang, W. J. Watkins, D. Babusis, I. N. Henne, M. J. Hawkins, I. D. Kurzman, R. Jeraj, M. Vanderhoek, S. Plaza, C. Anderson, M. A. Wessel, C. Robat, J. Lawrence, D. B. Tumas, Assessment of GS-9219 in a pet dog model of non-Hodgkin's lymphoma. Clin. Cancer Res. 15, 3503-3510 (2009).
52. P. J. R. Baneux, M. E. Martin, M. J. Allen, T. M. Hallman, Issues related to institutional animal care and use committees and clinical trials using privately owned animals. ILAR J. 55, 200-209 (2014).
53. L. L. Black, J. Gaynor, D. Gahring, C. Adams, D. Aron, S. Harman, D. A. Gingerich, R. Harman, Effect of adiposederived mesenchymal stem and regenerative cells on lameness in dogs with chronic osteoarthritis of the coxofemoral joints: A randomized, double-blinded, multicenter, controlled trial. Vet. Ther. 8, 272-284 (2007).
54. Y. Jiang, R. S. Tuan, Origin and function of cartilage stem/progenitor cells in osteoarthritis. Nat. Rev. Rheumatol. 11, 206-212 (2015).
55. J. C. Patterson-Kane, T. Rich, Achilles tendon injuries in elite athletes: Lessons in pathophysiology from their equine counterparts. ILAR J. 55, 86-99 (2014).
56. J. L. Cook, Cranial cruciate ligament disease in dogs: Biology versus biomechanics. Vet. Surg. 39, 270-277 (2010).
57. J. N. Lozier, T. C. Nichols, Animal models of hemophilia and related bleeding disorders. Semin. Hematol. 50, 175-184 (2013).
58. E. J. M. Mignot, History of narcolepsy at Stanford University. Immunol. Res. 58, 315-339 (2014).
59. L. E. Perryman, Molecular pathology of severe combined immunodeficiency in mice, horses, and dogs. Vet. Pathol. 41, 95-100 (2004).
60. Z. T. Wolf, H. A. Brand, J. R. Shaffer, E. J. Leslie, B. Arzi, C. E. Willet, T. C. Cox, T. McHenry, N. Narayan, E. Feingold, X. Wang, S. Sliskovic, N. Karmi, N. Safra, C. Sanchez, F. W. Deleyiannis, J. C. Murray, C. M. Wade, M. L. Marazita, D. L. Bannasch, Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. PLOS Genet. 11, e1005059 (2015).
61. J. W. McGreevy, C. H. Hakim, M. A. McIntosh, D. Duan, Animal models of Duchenne muscular dystrophy: From basic mechanisms to gene therapy. Dis. Model. Mech. 8, 195-213 (2015).
62. N. M. Ellinwood, C. H. Vite, M. E. Haskins, Gene therapy for lysosomal storage diseases: The lessons and promise of animal models. J. Gene Med. 6, 481-506 (2004).
63. J. R. Mickelson, S. J. Valberg, The genetics of skeletal muscle disorders in horses. Annu. Rev. Anim. Biosci. 3, 197-217 (2015).
64. M. Cerquetella, A. Spaterna, F. Laus, B. Tesei, G. Rossi, E. Antonelli, V. Villanacci, G. Bassotti, Inflammatory bowel disease in the dog: Differences and similarities with humans. World J. Gastroenterol. 16, 1050-1056 (2010).
65. A. E. Jergens, K. W. Simpson, Inflammatory bowel disease in veterinary medicine. Front. Biosci. (Elite Ed.) 4, 1404-1419 (2012).