메뉴 건너뛰기




Volumn 12, Issue 5, 2015, Pages 6849-6854

Spironolactone inhibits podocyte motility via decreasing integrin β1 and increasing integrin β3 in podocytes under high-glucose conditions

Author keywords

Integrin 1; Integrin 3; Podocyte; Spironolactone

Indexed keywords

BETA1 INTEGRIN; BETA3 INTEGRIN; GLUCOSE; SPIRONOLACTONE;

EID: 84943609141     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4295     Document Type: Article
Times cited : (15)

References (37)
  • 2
    • 0032737294 scopus 로고    scopus 로고
    • End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions
    • Ritz E, Rychlik I, Locatelli F and Halimi S: End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions. Am J Kidney Dis 34: 795-808, 1999.
    • (1999) Am J Kidney Dis , vol.34 , pp. 795-808
    • Ritz, E.1    Rychlik, I.2    Locatelli, F.3    Halimi, S.4
  • 3
    • 20044362239 scopus 로고    scopus 로고
    • From the periphery of the glomerular capillary wall toward the center of disease: Podocyte injury comes of age in diabetic nephropathy
    • Wolf G, Chen S and Ziyadeh FN: From the periphery of the glomerular capillary wall toward the center of disease: Podocyte injury comes of age in diabetic nephropathy. Diabetes 54: 1626-1634, 2005.
    • (2005) Diabetes , vol.54 , pp. 1626-1634
    • Wolf, G.1    Chen, S.2    Ziyadeh, F.N.3
  • 7
    • 38749153591 scopus 로고    scopus 로고
    • Podocyte injury in focal segmental glomerulosclerosis: Lessons from animal models (a play in five acts)
    • D'Agati VD: Podocyte injury in focal segmental glomerulosclerosis: Lessons from animal models (a play in five acts). Kidney Int 73: 399-406, 2008.
    • (2008) Kidney Int , vol.73 , pp. 399-406
    • D'Agati, V.D.1
  • 9
    • 84896517331 scopus 로고    scopus 로고
    • Wnt3a activates 1-integrin and regulates migration and adhesion of vascular smooth muscle cells
    • Wu X, Wang J, Jiang H, Hu Q, Chen J, Zhang J, Zhu R, Liu W and Li B: Wnt3a activates 1-integrin and regulates migration and adhesion of vascular smooth muscle cells. Mol Med Rep 9: 1159-1164, 2014.
    • (2014) Mol Med Rep , vol.9 , pp. 1159-1164
    • Wu, X.1    Wang, J.2    Jiang, H.3    Hu, Q.4    Chen, J.5    Zhang, J.6    Zhu, R.7    Liu, W.8    Li, B.9
  • 12
    • 0028979154 scopus 로고
    • Consequences of lack of beta 1 integrin gene expression in mice
    • Fassler R and Meyer M: Consequences of lack of beta 1 integrin gene expression in mice. Genes Dev 9: 1896-1908, 1995.
    • (1995) Genes Dev , vol.9 , pp. 1896-1908
    • Fassler, R.1    Meyer, M.2
  • 13
    • 37849026460 scopus 로고    scopus 로고
    • Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus
    • Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS and Gattone VH Jr and Kalluri R: Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol 313: 584-593, 2008.
    • (2008) Dev Biol , vol.313 , pp. 584-593
    • Kanasaki, K.1    Kanda, Y.2    Palmsten, K.3    Tanjore, H.4    Lee, S.B.5    Lebleu, V.S.6    Gattone, V.H.7    Kalluri, R.8
  • 16
    • 84875702158 scopus 로고    scopus 로고
    • Cell-matrix adhesion of podocytes in physiology and disease
    • Sachs N and Sonnenberg A: Cell-matrix adhesion of podocytes in physiology and disease. Nat Rev Nephrol 9: 200-210, 2013.
    • (2013) Nat Rev Nephrol , vol.9 , pp. 200-210
    • Sachs, N.1    Sonnenberg, A.2
  • 19
    • 33846443625 scopus 로고    scopus 로고
    • Podocyte as the target for aldosterone: Roles of oxidative stress and Sgk1
    • Shibata S, Nagase M, Yoshida S, Kawachi H and Fujita T: Podocyte as the target for aldosterone: Roles of oxidative stress and Sgk1. Hypertension 49: 355-364, 2007.
    • (2007) Hypertension , vol.49 , pp. 355-364
    • Shibata, S.1    Nagase, M.2    Yoshida, S.3    Kawachi, H.4    Fujita, T.5
  • 21
    • 84873953213 scopus 로고    scopus 로고
    • Effects of spironolactone administration on the podocytes loss and progression of experimental diabetic nephropathy
    • In Spanish
    • Aguilar C and Rodriguez-Delfin L: Effects of spironolactone administration on the podocytes loss and progression of experimental diabetic nephropathy. Rev Peru Med Exp Salud Publica 29: 490-497, 2012 (In Spanish).
    • (2012) Rev Peru Med Exp Salud Publica , vol.29 , pp. 490-497
    • Aguilar, C.1    Rodriguez-Delfin, L.2
  • 22
    • 77956297974 scopus 로고    scopus 로고
    • Spironolactone ameliorates podocytic adhesive capacity via restoring integrin alpha 3 expression in streptozotocin-induced diabetic rats
    • Lin S, Li D, Jia J, Zheng Z, Jia Z and Shang W: Spironolactone ameliorates podocytic adhesive capacity via restoring integrin alpha 3 expression in streptozotocin-induced diabetic rats. J Renin Angiotensin Aldosterone Syst 11: 149-157, 2010.
    • (2010) J Renin Angiotensin Aldosterone Syst , vol.11 , pp. 149-157
    • Lin, S.1    Li, D.2    Jia, J.3    Zheng, Z.4    Jia, Z.5    Shang, W.6
  • 23
    • 0031563832 scopus 로고    scopus 로고
    • Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
    • Mundel P, Reiser J, Zuniga Mejia Borja A, Pavenstadt H, Davidson GR, Kriz W and Zeller R: Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 236: 248-258, 1997.
    • (1997) Exp Cell Res , vol.236 , pp. 248-258
    • Mundel, P.1    Reiser, J.2    Zuniga Mejia Borja, A.3    Pavenstadt, H.4    Davidson, G.R.5    Kriz, W.6    Zeller, R.7
  • 24
    • 84862119511 scopus 로고    scopus 로고
    • Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria
    • Zhang B, Xie S, Shi W and Yang Y: Amiloride off-target effect inhibits podocyte urokinase receptor expression and reduces proteinuria. Nephrol Dial Transplant 27: 1746-1755, 2012.
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 1746-1755
    • Zhang, B.1    Xie, S.2    Shi, W.3    Yang, Y.4
  • 28
    • 33746325825 scopus 로고    scopus 로고
    • Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant inhibitor forintegrin alphavbeta3
    • Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG and Zent R. Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant inhibitor forintegrin alphavbeta3. J Biol Chem 281: 20932-20939, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 20932-20939
    • Borza, C.M.1    Pozzi, A.2    Borza, D.B.3    Pedchenko, V.4    Hellmark, T.5    Hudson, B.G.6    Zent, R.7
  • 29
    • 47649085301 scopus 로고    scopus 로고
    • Aldosterone and glomerular podocyte injury
    • Nagase M and Fujita T: Aldosterone and glomerular podocyte injury. Clin Exp Nephrol 12: 233-242, 2008.
    • (2008) Clin Exp Nephrol , vol.12 , pp. 233-242
    • Nagase, M.1    Fujita, T.2
  • 30
    • 46149104414 scopus 로고    scopus 로고
    • Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats
    • Siragy HM and Xue C: Local renal aldosterone production induces inflammation and matrix formation in kidneys of diabetic rats. Exp Physiol 93: 817-824, 2008.
    • (2008) Exp Physiol , vol.93 , pp. 817-824
    • Siragy, H.M.1    Xue, C.2
  • 34
    • 47549114629 scopus 로고    scopus 로고
    • Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats
    • Taira M, Toba H, Murakami M, Iga I, Serizawa R, Murata S, Kobara M and Nakata T: Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats. Eur J Pharmacol 589: 264-271, 2008.
    • (2008) Eur J Pharmacol , vol.589 , pp. 264-271
    • Taira, M.1    Toba, H.2    Murakami, M.3    Iga, I.4    Serizawa, R.5    Murata, S.6    Kobara, M.7    Nakata, T.8
  • 35
    • 33745683630 scopus 로고    scopus 로고
    • Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats
    • Han KH, Kang YS, Han SY, Jee YH, Lee MH, Han JY, Kim HK, Kim YS and Cha DR: Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats. Kidney Int 70: 111-120, 2006.
    • (2006) Kidney Int , vol.70 , pp. 111-120
    • Han, K.H.1    Kang, Y.S.2    Han, S.Y.3    Jee, Y.H.4    Lee, M.H.5    Han, J.Y.6    Kim, H.K.7    Kim, Y.S.8    Cha, D.R.9
  • 36
    • 84864023693 scopus 로고    scopus 로고
    • Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: A randomized placebo-controlled crossover study
    • Nielsen SE, Persson F, Frandsen E, Sugaya T, Hess G, Zdunek D, Shjoedt KJ, Parving HH and Rossing P: Spironolactone diminishes urinary albumin excretion in patients with type 1 diabetes and microalbuminuria: A randomized placebo-controlled crossover study. Diabet Med 29: e184-e190, 2012.
    • (2012) Diabet Med , vol.29 , pp. e184-e190
    • Nielsen, S.E.1    Persson, F.2    Frandsen, E.3    Sugaya, T.4    Hess, G.5    Zdunek, D.6    Shjoedt, K.J.7    Parving, H.H.8    Rossing, P.9
  • 37
    • 24144495285 scopus 로고    scopus 로고
    • Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: A randomized, double-masked, cross-over study
    • Rossing K, Schjoedt KJ, Smidt UM, Boomsma F and Parving HH: Beneficial effects of adding spironolactone to recommended antihypertensive treatment in diabetic nephropathy: A randomized, double-masked, cross-over study. Diabetes Care 28: 2106-2112, 2005.
    • (2005) Diabetes Care , vol.28 , pp. 2106-2112
    • Rossing, K.1    Schjoedt, K.J.2    Smidt, U.M.3    Boomsma, F.4    Parving, H.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.