UPLC-HRMS based metabolomics reveals the sphingolipids with long fatty chains and olefinic bonds up-regulated in metabolic pathway for hypoxia preconditioning

Chemico-Biological Interactions

Volumn 242, Issue , 2015, Pages 145-152

  Zhou, Tao ^a   Wang, Mingming ^a,b   Cheng, Haiting ^a,c   Cui, Can ^a   Su, Su ^a   Xu, Pingxiang ^a   Xue, Ming ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

HPC; Metabolic pathway; Metabolomics; Sphingolipids; UPLC HRMS

Indexed keywords

ALKENE; CERAMIDE; DRUG METABOLITE; GALACTOSYLCERAMIDE; GLUCOSYLCERAMIDE; LACTOSYLCERAMIDE; SPHINGOLIPID; SPHINGOMYELIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CHEMICAL BOND; CONTROLLED STUDY; DOWN REGULATION; HYPOXIA PRECONDITIONING; LIPID ANALYSIS; LIPID METABOLISM; MALE; MASS SPECTROMETRY; METABOLOMICS; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; UPREGULATION; ANIMAL; ANOXIA; CHEMISTRY; DISEASE MODEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PROCEDURES;

ANIMALS; ANOXIA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; MALE; MASS SPECTROMETRY; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MICE, INBRED ICR; SPHINGOLIPIDS; UP-REGULATION;

EID: 84943596079     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2015.09.026     Document Type: Article

References (42)

1. R. Ran, H. Xu, A. Lu, M. Bernaudin, and F.R. Sharp Hypoxia preconditioning in the brain Dev. Neurosci. 27 2005 87 92
2. A. Janoff Alterations in lysosomes (intracellular enzymes) during shock; effects of preconditioning (tolerance) and protective drugs Int. Anesthesiol. Clin. 2 1964 251 269
3. M.A. Saad, R.M. Abdelsalam, S.A. Kenawy, and A.S. Attia Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia- reperfusion in rats Chem Biol. Interact. 232 2015 21 29
4. S.X. Zhang, J.J. Miller, D. Gozal, and Y. Wang Whole-body hypoxic preconditioning protects mice against acute hypoxia by improving lung function J. Appl. Physiol. 96 2004 392 397
5. A.M. Stowe, T. Altay, A.B. Freie, and J.M. Gidday Repetitive hypoxia extends endogenous neurovascular protection for stroke Ann. Neurol. 69 2011 975 985
6. B.K. Wacker, J.L. Perfater, and J.M. Gidday Hypoxic preconditioning induces stroke tolerance in mice via a cascading HIF, sphingosine kinase, and CCL2 signaling pathway J. Neurochem. 123 2012 954 962
7. Y. Gao, G. Gao, C. Long, S. Han, P. Zu, L. Fang, and J. Li Enhanced phosphorylation of cyclic AMP response element binding protein in the brain of mice following repetitive hypoxic exposure Biochem. Biophys. Res. Commun. 340 2006 661 667
8. G.W. Lu, and H.Y. Liu Downregulation of nitric oxide in the brain of mice during their hypoxic preconditioning J. Appl. Physiol. 91 2001 1193 1198
9. M.M. Wang, L.J. Wang, Y. Chen, X.R. Li, L.G. W, and X. M Establishment of the prediction model of tolerance time of mice and rats exposed to hypoxia Chin. J. Comp. Med. 11 2008 21 23
10. G.W. Lu, S. Yu, R.H. Li, X.Y. Cui, and C.Y. Gao Hypoxic preconditioning: a novel intrinsic cytoprotective strategy Mol. Neurobiol. 31 2005 255 271
11. L. Bennet, L. Booth, and A.J. Gunn Potential biomarkers for hypoxic-ischemic encephalopathy Semin. Fetal Neonat. M. 15 2010 253 260
12. M. Hernandez-Jimenez, S. Sacristan, C. Morales, M. Garcia-Villanueva, E. Garcia-Fernandez, A. Alcazar, V.M. Gonzalez, and M.E. Martin Apoptosis-related proteins are potential markers of neonatal hypoxic-ischemic encephalopathy (HIE) injury Neurosci. Lett. 558 2014 143 148
13. Can Cui, Tao Zhou, Jingyi Li, Hong Wang, Xiaorong Li, Jie Xiong, Pingxiang Xu, and Ming Xue Proteomic analysis of the mouse brain after repetitive exposure to hypoxia Chem. Biol. Int. 236 2015 57 66
14. H.M. Park, J. Shin, J.K. Kim, S.J. Lee, G. Hwang, K. Liu, and C.H. Lee MS-based metabolite profiling reveals time-dependent skin biomarkers in UVB-irradiated mice Metabolomics 10 2014 663 676
15. D. Krug, and R. Muller Secondary metabolomics: the impact of mass spectrometry-based approaches on the discovery and characterization of microbial natural products Nat. Prod. Rep. 31 2014 768 783
16. X. Gao, M. Guo, B. Zhao, L. Peng, J. Su, X. Bai, J. Li, and Y. Qiao A urinary metabonomics study on biochemical changes in yeast-induced pyrexia rats: a new approach to elucidating the biochemical basis of the febrile response Chem Biol. Interact. 204 2013 39 48
17. E-based metabonomics for adenine-induced changes in metabolic profiles of rat feces and intervention effects of ergosta-4,6,8(14),22-tetraen-3-one Chem Biol. Interact. 201 2013 31 38
18. M. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110
19. W. Shao, S. Fan, Y. Lei, G. Yao, J. Chen, J. Zhou, H. Xu, H. Liu, B. Wu, P. Zheng, L. Fang, and P. Xie Metabolomic identification of molecular changes associated with stress resilience in the chronic mild stress rat model of depression Metabolomics 9 2013 433 443
20. D.S. Wishart, C. Knox, A.C. Guo, and et al. HMDB: a knowledgebase for the human metabolome Nucleic Acids Res. 37 2009 603 610
21. M. Kanehisa, and S. Goto KEGG: kyoto encyclopedia of genes and genomes Nucleic Acids Res. 28 2000 27 30
22. J. Xia, and D.S. Wishart Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst Nat. Protoc. 6 2011 743 760
23. J. Xia, N. Psychogios, N. Young, and D.S. Wishart MetaboAnalyst: a web server for metabolomic data analysis and interpretation Nucleic Acids Res. 37 2009 652 660
24. E.C. Laiakis, K. Strassburg, R. Bogumil, S. Lai, R.J. Vreeken, T. Hankemeier, J. Langridge, R.S. Plumb, A.J. Fornace, and G. Astarita Metabolic phenotyping reveals a lipid mediator response to ionizing radiation J. Proteome Res. 13 2014 4143 4154
25. R. Goodacre, S. Vaidyanathan, W.B. Dunn, G.G. Harrigan, and D.B. Kell Metabolomics by numbers: acquiring and understanding global metabolite data Trends Biotechnol. 22 2004 245 252
26. S. Wiklund, E. Johansson, L. Sjostrom, E.J. Mellerowicz, U. Edlund, J.P. Shockcor, J. Gottfries, T. Moritz, and J. Trygg Visualization of GC/TOF-MS-based metabolomics data for identification of biochemically interesting compounds using OPLS class models Anal. Chem. 80 2008 115 122
27. C.P. Reynolds, B.J. Maurer, and R.N. Kolesnick Ceramide synthesis and metabolism as a target for cancer therapy Cancer Lett. 206 2004 169 180
28. Y.A. Hannun, and L.M. Obeid Many ceramides J. Biol. Chem. 286 2011 27855 27862
29. C. Cui, H. Chen, S. Su, B.B. Xia, W.W. Gong, P.X. Xu, and M. Xue Identification of key genes related to hypoxia preconditioning by gene-chip and network analysis Acta Pharmacol. Sin. 34 2013 S148
30. T. Kolter A view on sphingolipids and disease Chem.Phys. Lipids 164 2011 590 600
31. S.N. Pinto, L.C. Silva, A.H. Futerman, and M. Prieto Effect of ceramide structure on membrane biophysical properties: the role of acyl chain length and unsaturation BBA Biomembr. 1808 2011 2753 2760
32. Y. Yu, L. Vidalino, A. Anesi, P. Macchi, and G. Guella A lipidomics investigation of the induced hypoxia stress on HeLa cells by using MS and NMR techniques Mol. Biosyst. 10 2014 878
33. J. Liu, I. Ginis, M. Spatz, and J.M. Hallenbeck Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide Am. J. Physiol. Cell Physiol. 278 2000 C144 C153
34. Y. Chen, I. Ginis, and J.M. Hallenbeck The protective effect of ceramide in immature rat brain hypoxia-ischemia involves up-regulation of bcl-2 and reduction of Tunel-positive cells J. Cereb. Blood F. Metab. 21 2001 34 40
35. M.I. Bhuiyan, M.N. Islam, S.Y. Jung, H.H. Yoo, Y.S. Lee, and C. Jin Involvement of ceramide in ischemic tolerance induced by preconditioning with sublethal oxygen-glucose deprivation in primary cultured cortical neurons of rats Biol. Pharm. Bull. 33 2010 11 17
36. I. Becker, L. Wang-Eckhardt, A. Yaghootfam, V. Gieselmann, and M. Eckhardt Differential expression of (dihydro) ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2 Histochem. Cell Biol. 129 2008 233 241
37. S.C. Phillips, G. Triola, G. Fabrias, F.M. Goñi, and M.C. Yappert cis-versus trans-ceramides: effects of the double bond on conformation and H-bonding interactions J. Phys. Chem. B 113 2009 15249 15255
38. S. Grösch, S. Schiffmann, and G. Geisslinger Chain length-specific properties of ceramides Prog. Lipid Res. 51 2012 50 62
39. S.S. Raza, A.C. Dumaual, D. LoCassio, R.A. Siddiqui, and W. Stillwell Acyl chain unsaturation in PEs modulates phase separation from lipid raft molecules Biochem. Biophys. Res. Commun. 311 2003 793 796
40. Y. Pewzner-Jung, S. Ben-Dor, and A.H. Futerman When do lasses (longevity assurance genes) become CerS (ceramide synthases) J. Biol. Chem. 281 2006 25001 25005
41. M.L. Allende, and R.L. Proia Simplifying complexity: genetically resculpting glycosphingolipid synthesis pathways in mice to reveal function Glycoconj. J. 31 2014 613 622
42. N. Bartke, and Y.A. Hannun Bioactive sphingolipids: metabolism and function J. Lipid Res. 50 2009 S91 S96