Kaempferol Identified by Zebrafish Assay and Fine Fractionations Strategy from Dysosma versipellis Inhibits Angiogenesis through VEGF and FGF Pathways

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Liang, Fang ^a   Han, Yuxiang ^a   Gao, Hao ^b   Xin, Shengchang ^a   Chen, Shaodan ^b   Wang, Nan ^a   Qin, Wei ^a   Zhong, Hanbing ^c   Lin, Shuo ^a,d   Yao, Xinsheng ^b   Li, Song ^a  

^a PEKING UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; FIBROBLAST GROWTH FACTOR; KAEMPFEROL; KAEMPFEROL DERIVATIVE; KDR PROTEIN, ZEBRAFISH; MOLECULAR LIBRARY; PLANT EXTRACT; VASCULOTROPIN RECEPTOR 2; ZEBRAFISH PROTEIN;

ANGIOGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; BERBERIDACEAE; BIOASSAY; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; CHINESE MEDICINE; DRUG EFFECTS; FRACTIONATION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MEDICINAL PLANT; METABOLISM; MOLECULAR LIBRARY; NONMAMMALIAN EMBRYO; PHARMACOLOGY; PROCEDURES; TRANSGENIC ANIMAL; UMBILICAL VEIN ENDOTHELIAL CELL; ZEBRA FISH;

ANGIOGENESIS INHIBITORS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BERBERIDACEAE; BIOLOGICAL ASSAY; CELL MOVEMENT; CELL PROLIFERATION; CHEMICAL FRACTIONATION; EMBRYO, NONMAMMALIAN; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; KAEMPFEROLS; MEDICINE, CHINESE TRADITIONAL; NEOVASCULARIZATION, PHYSIOLOGIC; PLANT EXTRACTS; PLANTS, MEDICINAL; SMALL MOLECULE LIBRARIES; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 84943593751     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep14468     Document Type: Article

References (35)

1. Koehn, F. E. & Carter, G. T. The evolving role of natural products in drug discovery. Nat Rev Drug Discov 4, 206-20 (2005)
2. Newman, D. J. & Cragg, G. M. Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010. Journal of Natural Products 75, 311-335 (2012)
3. Cragg, G. M., Grothaus, P. G. & Newman, D. J. Impact of Natural Products on Developing New Anti-Cancer Agents. Chemical Reviews 109, 3012-3043 (2009)
4. Zhong, H., Liu, N. & Lin, S. Zebrafish Models for Human Diseases and Drug Discovery. in Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools (eds. Ekins, S. & Xu, J. J.) 115-133 (John Wiley & Sons, Inc., Hoboken, NJ, USA, 2009)
5. Zon, L. I. & Peterson, R. T. In vivo drug discovery in the zebrafish. Nat Rev Drug Discov 4, 35-44 (2005)
6. Crawford, A. D. et al. Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East african medicinal plants. PLoS One 6, e14694 (2011)
7. Garkavtsev, I. et al. Dehydro-alpha-lapachone, a plant product with antivascular activity. Proc Natl Acad Sci USA 108, 11596-601 (2011)
8. Isogai, S., Horiguchi, M. & Weinstein, B. M. The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development. Dev Biol 230, 278-301 (2001)
9. Childs, S., Chen, J. N., Garrity, D. M. & Fishman, M. C. Patterning of angiogenesis in the zebrafish embryo. Development 129, 973-82 (2002)
10. Cross, L. M., Cook, M. A., Lin, S., Chen, J. N. & Rubinstein, A. L. Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay. Arterioscler Thromb Vasc Biol 23, 911-2 (2003)
11. Cooney, M. M., van Heeckeren, W., Bhakta, S., Ortiz, J. & Remick, S. C. Drug Insight: vascular disrupting agents and angiogenesis-novel approaches for drug delivery. Nature Clinical Practice Oncology 3, 682-692 (2006)
12. Tran, T. C. et al. Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Research 67, 11386-11392 (2007)
13. Ferrara, N. & Kerbel, R. S. Angiogenesis as a therapeutic target. Nature 438, 967-974 (2005)
14. Folkman, J., Ingber, D. & Vlodavsky, I. The role of angiogenesis in tumor-growth. Investigational New Drugs 5, 103-103 (1987)
15. Ferrara, N. Vascular endothelial growth factor as a target for anticancer therapy. Oncologist 9, 2-10 (2004)
16. Liang, G., Liu, Z., Wu, J., Cai, Y. & Li, X. Anticancer molecules targeting fibroblast growth factor receptors. Trends in Pharmacological Sciences 33, 531-541 (2012)
17. Meadows, K. N., Bryant, P. & Pumiglia, K. Vascular endothelial growth factor induction of the angiogenic phenotype requires Ras activation. Journal of Biological Chemistry 276, 49289-49298 (2001)
18. China, E.C.o.Z.H.B.C.o.S.A.o.T.C.M.o.P.s.R.o. (ed.) Zhong Hua Ben Cao. 304-308 (Shanghai Scientific and Technical Publishers, Shanghai, 1999)
19. Hsiao, W. L. & Liu, L. The role of traditional Chinese herbal medicines in cancer therapy-from TCM theory to mechanistic insights. Planta Med 76, 1118-31 (2010)
20. McChesney, J. D., Venkataraman, S. K. & Henri, J. T. Plant natural products: Back to the future or into extinction? Phytochemistry 68, 2015-2022 (2007)
21. Hakkinen, S. H., Karenlampi, S. O., Heinonen, I. M., Mykkanen, H. M. & Torronen, A. R. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J Agric Food Chem 47, 2274-9 (1999)
22. Park, J. S., Rho, H. S., Kim, D. H. & Chang, I. S. Enzymatic preparation of kaempferol from green tea seed and its antioxidant activity. J Agric Food Chem 54, 2951-6 (2006)
23. Luo, H. et al. Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutr Cancer 61, 554-63 (2009)
24. Sen, P., Mukherjee, S., Ray, D. & Raha, S. Involvement of the Akt/PKB signaling pathway with disease processes. Molecular and Cellular Biochemistry 253, 241-246 (2003)
25. Holmes, K., Roberts, O. L., Thomas, A. M. & Cross, M. J. Vascular endothelial growth factor receptor-2: Structure, function, intracellular signalling and therapeutic inhibition. Cellular Signalling 19, 2003-2012 (2007)
26. Nillesen, S. T. M. et al. Increased angiogenesis and blood vessel maturation in acellular collagen-heparin scaffolds containing both FGF2 and VEGF. Biomaterials 28, 1123-1131 (2007)
27. Rousseau, S. et al. Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase. Journal of Biological Chemistry 275, 10661-10672 (2000)
28. Zhou, Y. et al. Chemical Fingerprinting of Medicinal Plants "Gui-jiu" by LC-ESI Multiple-Stage MS. Chromatographia 68, 781-789 (2008)
29. Canel, C., Moraes, R. M., Dayan, F. E. & Ferreira, D. Podophyllotoxin. Phytochemistry 54, 115-120 (2000)
30. Mojzis, J., Varinska, L., Mojzisova, G., Kostova, I. & Mirossay, L. Antiangiogenic effects of flavonoids and chalcones. Pharmacological Research 57, 259-265 (2008)
31. Cross, M. J. & Claesson-Welsh, L. FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends in Pharmacological Sciences 22, 201-207 (2001)
32. Lee, H. S. et al. Mechanisms underlying apoptosis-inducing effects of Kaempferol in HT-29 human colon cancer cells. International journal of molecular sciences 15, 2722-37 (2014)
33. Luo, H., Rankin, G. O., Juliano, N., Jiang, B. H. & Chen, Y. C. Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NF kappa B-cMyc-p21 pathway. Food Chemistry 130, 321-328 (2012)
34. Murakami, M. et al. FGF-dependent regulation of VEGF receptor 2 expression in mice. Journal of Clinical Investigation 121, 2668-2678 (2011)
35. Kimmel, C. B., Ballard, W. W., Kimmel, S. R., Ullmann, B. & Schilling, T. F. Stages of embryonic development of the zebrafish. Dev Dyn 203, 253-310 (1995)