Transsclera drug delivery by pulsed High-Intensity Focused Ultrasound (HIFU): An ex vivo study

Current Eye Research

Volumn 40, Issue 11, 2015, Pages 1172-1180

  Murugappan, Suresh Kanna ^a   Zhou, Yufeng ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

Fluorescence; high intensity focused ultrasound; penetration; pulse duration; transsclera drug delivery

Indexed keywords

ACID; BICINCHONINIC ACID; REAGENT; RHODAMINE; UNCLASSIFIED DRUG; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; FLUORESCENT DYE; QUINOLINE DERIVATIVE; RHODAMINE 6G;

ACOUSTICS; AMPLIFIER; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA STROMA; DRUG DELIVERY SYSTEM; DRUG DIFFUSION; ELECTRON MICROSCOPY; EX VIVO STUDY; FEASIBILITY STUDY; FLUORESCENCE; FLUORESCENCE MICROSCOPY; HIGH INTENSITY FOCUSED ULTRASOUND; HIGH INTENSITY FOCUSED ULTRASOUND DEVICE; NONHUMAN; PIG; PRIORITY JOURNAL; PULSE GENERATOR; SCANNING ELECTRON MICROSCOPY; SCLERA; SURFACE ELECTRON MICROSCOPY; SURFACE PROPERTY; TOPICAL DRUG ADMINISTRATION; ULTRASOUND TRANSDUCER; ANIMAL; BODY TEMPERATURE; DRUG EFFECTS; PROCEDURES; TRANSDUCER; ULTRASTRUCTURE;

ANIMALS; BODY TEMPERATURE; DRUG DELIVERY SYSTEMS; FEASIBILITY STUDIES; FLUORESCENT DYES; HIGH-INTENSITY FOCUSED ULTRASOUND ABLATION; INDICATORS AND REAGENTS; MICROSCOPY, ELECTRON, SCANNING; QUINOLINES; RHODAMINES; SCLERA; SWINE; TRANSDUCERS;

EID: 84943587623     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2014.980006     Document Type: Article

References (32)

1. Geroski DH, Edelhauser, HF. Transscleral drug delivery. In: Kompella UB, Edelhauser HF., editors. Drug product development for the back of the eye. Boston: Springer; 2011. pp. 159-171
2. Cheung ACY, Yu Y, Tay D, Wong HS, Ellis-Behnke R, Chau Y. Ultrasound-enhanced intraclera delivery of protein. Int J Pharmaceut 2010; 401: 16-24
3. Nomoto H, Shiraga F, Kuno N, Kimura E, Fujii S, Shinomiya K, et al. Pharmacokinetics of bevacizumab after topical, subconjunctival, and intravitreal administration in rabbits. Invest Ophthalmol Vis Sci 2009; 50: 4807-4813
4. Urtti A. Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv Drug Deliver Rev 2006; 58: 1131-1135
5. Ambati J, Adamis AP. Transscleral drug delivery to the retina and choroid. Prog Retin Eye Res 2002; 21: 145-151
6. del Amo EM, Urtti A. Current and future ophthalmic drug delivery systems: a shift to the posterior segment. Drug Discov Today 2008; 13: 135-143
7. Naik R, Mukhopadhyay A, Ganguli M. Gene delivery to the retina: focus on non-viral approaches. Drug Discov Today 2009; 14: 306-315
8. Geroski DH, Edelhauser HF. Transscleral drug delivery for posterior segment disease. Adv Drug Deliver Rev 2001; 52: 37-48
9. Olsen TW, Edelhauser HF, Lim JI, Geroski DH. Human scleral permeability: effects of age, cryotherapy, transscleral diode laser, and surgical thinning. Invest Ophthalmol Vis Sci 1995; 36: 1893-1903
10. Eljarrat-Binstock E, Domb AJ. Iontophoresis: a non-invasive ocular drug delivery. J Control Release 2006; 110: 479-489
11. Myles ME, Neumann DM, Hill JM. Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis. Adv Drug Deliver Rev 2005; 57: 2063-2079
12. Behar-Cohen FF, Halhal M, BenEzra D, Chauvaud D, Renard G. Reversal of corneal graft reject by iontophoresis of methylprednisolone. Invest Ophthalmol Vis Sci 2002; 43: 2214
13. Sarraf D, Lee DA. The role of iontophoresis in ocular drug delivery. J Ocul Pharmacol 1994; 10: 69-81
14. Barza M. Transscleral iontophoresis of cefazolin, cicarcillin, and gentamicin in the rabbit. Ophthalmology 1986; 93: 133-139
15. Barza M, Peckman C, Baum J. Transscleral iontophoresis of cefazolin, cicarcillin, and gentamicin in the rabbit. Ophthalmology 1986; 93: 133-139
16. Zhou YF. Ultrasound-mediated drug/gene delivery in solid tumor treatment. J Healthc Eng 2013; 4: 223-254
17. Rao R, Nanda S. Sonophoresis: recent advancements and future trends. J Pharm Pharmacol 2010; 61: 689-705
18. Zderic V, Vaezy S, Martin RW, Clark JI. Ocular drug delivery using 20-kHz ultrasound. Ultrasound Med Biol 2002; 28: 823-829
19. Zhou YF. High intensity focused ultrasound in clinical tumor ablation. World J Clin Oncol 2011; 2: 8-27
20. Yuh EL, Shulman SG, Mehta S, Xie J, Chen L, Frenkel V, et al. Delivery of systemic chemotherapeutic agent to tumors by using focused ultrasound: study in a murine model. Radiology 2005; 234: 431-437
21. Zhou YF, Zhai L, Simmons R, Zhong P. Measurement of high intensity focused ultrasound fields by a fiber optic probe hydrophone. J Acoust Soc Am 2006; 120: 676-685
22. Noble JE, Knight AE, Reason AJ, Di Matola A, Bailey MJA. A comparison of protein quantitation assays for biopharmaceutical applications. Mol Biotechnol 2007; 37: 99-111
23. Xu Z, Ludomirsky A, Eun LY, Hall TL, Tran BC, Fowlkes JB, et al. Controlled ultrasound tissue erosion. IEEE Trans Ultrason Ferroelectr Freq Control 2004; 51: 726-736
24. Maxwell A, Sapozhnikov O, Bailey M, Crum L, Xu Z, Fowlkes B, et al. Disintegration of tissue using high intensity focused ultrasound: two approaches that utilize shock waves. Acoustics Today 2012; 8: 24-37
25. Zhang L, Zhu H, Jin C, Zhou K, Li K, Su H, et al. High-intensity focused ultrasound (HIFU): effective and safe therapy for hepatocellular carcinoma adjacent to major hepatic veins. Eur Radiol 2009; 19: 437-445
26. Arvanitis CD, Bazan-Peregrino M, Rifai B, Seymour LW, Coussios C-C. Cavitation-enhanced extravasation for drug delivery. Ultrasound Med Biol 2011; 37: 1838-1852
27. Byl NN. The use of ultrasound as an enhancer for transcutaneous drug delivery: phonophoresis. Phys Ther 1995; 75: 529-553
28. Hernot S, Klibanov AL. Microbubbles in ultrasound-Triggered drug and gene delivery. Adv Drug Deliver Rev 2008; 60: 1153-1166
29. Liu Y, Miyoshi H, Nakamura M. Encapsulated ultrasound microbubbles: therapeutic application in drug/gene delivery. J Control Release 2006; 114: 89-99
30. Leong-Poi H, Kuliszewski MA, Lekas M, Sibbald M, Teichert-Kuliszewska K, Klibanov AL, et al. Therapeutic arteriogenesis by ultrasound-mediated VEGF 165 plasmid gene delivery to chronically ischemic skeletal muscle. Cir Res 2007; 101: 295-303
31. Balachandran RK, Barocas VH. Computer modeling of drug delivery to the posteior eye: effect of active transport and loss to choroidal blood flow. Pharm Res 2008; 25: 2685-2696
32. Kim H, Robinson MR, Lizak MJ, Tansey G, Lutz RJ, Yuan P, et al. Controlled drug release from an ocular implant: an evaluation using dynamic three-dimensional magnetic resonance imaging. Invest Ophthalmol Vis Sci 2004; 45: 2722-2731