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Volumn 234, Issue 2, 2005, Pages 431-437

Delivery of systemic chemotherapeutic agent to tumors by using focused ultrasound: Study in a murine model

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN;

EID: 12344335066     PISSN: 00338419     EISSN: None     Source Type: Journal    
DOI: 10.1148/radiol.2342030889     Document Type: Article
Times cited : (123)

References (50)
  • 1
    • 0029983156 scopus 로고    scopus 로고
    • Delivery of molecular medicine to solid tumors
    • Jain RK. Delivery of molecular medicine to solid tumors. Science 1996; 271:1079-1080.
    • (1996) Science , vol.271 , pp. 1079-1080
    • Jain, R.K.1
  • 2
    • 0028845764 scopus 로고
    • Monoclonal antibodies at age 20: Promise at last?
    • Hall SS. Monoclonal antibodies at age 20: promise at last? Science 1995; 270:915-916.
    • (1995) Science , vol.270 , pp. 915-916
    • Hall, S.S.1
  • 3
    • 0028470454 scopus 로고
    • Barriers to drug delivery in solid tumors
    • Jain RK. Barriers to drug delivery in solid tumors. Sci Am 1994; 271:58-65.
    • (1994) Sci Am , vol.271 , pp. 58-65
    • Jain, R.K.1
  • 4
    • 0032872567 scopus 로고    scopus 로고
    • Monoclonal antibody drug conjugates in the treatment of cancer
    • Trail P, Bianchi AB. Monoclonal antibody drug conjugates in the treatment of cancer. Curr Opin Immunol 1999; 11:584-588.
    • (1999) Curr Opin Immunol , vol.11 , pp. 584-588
    • Trail, P.1    Bianchi, A.B.2
  • 5
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 6
    • 1642536758 scopus 로고
    • Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice
    • Torres Filho IP, Leunig M, Yuan F, Intaglietta M, Jain RK. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proc Natl Acad Sci U S A 1994; 91: 2081-2085.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 2081-2085
    • Torres Filho, I.P.1    Leunig, M.2    Yuan, F.3    Intaglietta, M.4    Jain, R.K.5
  • 7
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • Helmlinger G, Yuan F, Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med 1997; 3:177-182.
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 8
    • 0032781104 scopus 로고    scopus 로고
    • Doxorubicin gradients in human breast cancer
    • Lankelma J, Dekker H, Luque RF, et al. Doxorubicin gradients in human breast cancer. Clin Cancer Res 1999; 5:1703-1707.
    • (1999) Clin Cancer Res , vol.5 , pp. 1703-1707
    • Lankelma, J.1    Dekker, H.2    Luque, R.F.3
  • 9
    • 13044292648 scopus 로고    scopus 로고
    • Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules
    • Netti PA, Hamberg LM, Babich JW, et al. Enhancement of fluid filtration across tumor vessels: implication for delivery of macromolecules. Proc Natl Acad Sci U S A 1999; 96:3137-3143.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3137-3143
    • Netti, P.A.1    Hamberg, L.M.2    Babich, J.W.3
  • 10
    • 0035139492 scopus 로고    scopus 로고
    • Caelyx (stealth liposomal doxorubicin) in the treatment of advanced breast cancer
    • Ranson MR, Cheeseman S, White S, Margison J. Caelyx (stealth liposomal doxorubicin) in the treatment of advanced breast cancer. Crit Rev Oncol Hematol 2001; 37:115-120.
    • (2001) Crit Rev Oncol Hematol , vol.37 , pp. 115-120
    • Ranson, M.R.1    Cheeseman, S.2    White, S.3    Margison, J.4
  • 11
    • 0031887949 scopus 로고    scopus 로고
    • Comparative study of the antitumor activity of free doxorubicin and polyethylene glycol-coated liposomal doxorubicin in a mouse lymphoma model
    • Cabanes A, Tzemach D, Goren D, Horowitz AT, Gabizon A. Comparative study of the antitumor activity of free doxorubicin and polyethylene glycol-coated liposomal doxorubicin in a mouse lymphoma model. Clin Cancer Res 1998; 4:499-505.
    • (1998) Clin Cancer Res , vol.4 , pp. 499-505
    • Cabanes, A.1    Tzemach, D.2    Goren, D.3    Horowitz, A.T.4    Gabizon, A.5
  • 12
    • 0033368732 scopus 로고    scopus 로고
    • Antitumor activity of Herceptin in combination with STEALTH liposomal cisplatin or nonliposomal cisplatin in a HER2 positive human breast cancer model
    • Colbern GT, Hiller AJ, Musterer RS, Working PK, Henderson IC. Antitumor activity of Herceptin in combination with STEALTH liposomal cisplatin or nonliposomal cisplatin in a HER2 positive human breast cancer model. J Inorg Biochem 1999; 77(1-2):117-120.
    • (1999) J Inorg Biochem , vol.77 , Issue.1-2 , pp. 117-120
    • Colbern, G.T.1    Hiller, A.J.2    Musterer, R.S.3    Working, P.K.4    Henderson, I.C.5
  • 13
    • 0034913822 scopus 로고    scopus 로고
    • Factors affecting the accelerated blood clearance of poly-ethylene- glycol-liposomes upon repeated injection
    • Laverman P, Carstens MG, Boerman OC, et al. Factors affecting the accelerated blood clearance of poly-ethylene-glycol-liposomes upon repeated injection. J Pharmacol Exp Ther 2001; 298:607-612.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 607-612
    • Laverman, P.1    Carstens, M.G.2    Boerman, O.C.3
  • 14
    • 0035300546 scopus 로고    scopus 로고
    • Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature
    • Kong G, Braun RD, Dewhirst MW. Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature. Cancer Res 2001; 61:3027-3032.
    • (2001) Cancer Res , vol.61 , pp. 3027-3032
    • Kong, G.1    Braun, R.D.2    Dewhirst, M.W.3
  • 15
    • 0034671219 scopus 로고    scopus 로고
    • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: Importance of triggered drug release
    • Kong G, Anyarambhatla G, Petros WP, et al. Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. Cancer Res 2000; 60:6950-6957.
    • (2000) Cancer Res , vol.60 , pp. 6950-6957
    • Kong, G.1    Anyarambhatla, G.2    Petros, W.P.3
  • 16
    • 0034161921 scopus 로고    scopus 로고
    • A new temperature-sensitive liposome for use with mild hyperthermia: Characterization and testing in a human tumor xenograft model
    • Needham D, Anyarambhatla G, Kong G, Dewhirst MD. A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. Cancer Res 2000; 60:1197-1201.
    • (2000) Cancer Res , vol.60 , pp. 1197-1201
    • Needham, D.1    Anyarambhatla, G.2    Kong, G.3    Dewhirst, M.D.4
  • 17
    • 0031469244 scopus 로고    scopus 로고
    • Hyperthermic treatment of malignant diseases: Current status and a view toward the future
    • Dewhirst MW, Prosnitz L, Thrall D, et al. Hyperthermic treatment of malignant diseases: current status and a view toward the future. Semin Oncol 1997; 24:616-625.
    • (1997) Semin Oncol , vol.24 , pp. 616-625
    • Dewhirst, M.W.1    Prosnitz, L.2    Thrall, D.3
  • 18
    • 0034234266 scopus 로고    scopus 로고
    • Heat-induced gene expression as a novel targeted cancer gene therapy strategy
    • Huang Q, Hu JK, Lohr F, et al. Heat-induced gene expression as a novel targeted cancer gene therapy strategy. Cancer Res 2000; 60:3435-3439.
    • (2000) Cancer Res , vol.60 , pp. 3435-3439
    • Huang, Q.1    Hu, J.K.2    Lohr, F.3
  • 19
    • 0036188362 scopus 로고    scopus 로고
    • Transrectal high-intensity focused ultrasound for treatment of patients with stage T1b-2n0m0 localized prostate can - A preliminary report
    • Uchida T, Sanghvi NT, Gardner TA, et al. Transrectal high-intensity focused ultrasound for treatment of patients with stage T1b-2n0m0 localized prostate can-a preliminary report. Urology 2002; 59:394-399.
    • (2002) Urology , vol.59 , pp. 394-399
    • Uchida, T.1    Sanghvi, N.T.2    Gardner, T.A.3
  • 20
    • 0036281005 scopus 로고    scopus 로고
    • Tumor vessel destruction resulting from high-intensity focused ultrasound in patients with solid malignancies
    • Wu F, Chen WZ, Bai J, et al. Tumor vessel destruction resulting from high-intensity focused ultrasound in patients with solid malignancies. Ultrasound Med Biol 2002; 28:535-542.
    • (2002) Ultrasound Med Biol , vol.28 , pp. 535-542
    • Wu, F.1    Chen, W.Z.2    Bai, J.3
  • 21
    • 0032826256 scopus 로고    scopus 로고
    • Local control of prostate cancer by transrectal high intensity focused ultrasound therapy: Preliminary results
    • Gelet A, Chapelon JY, Bouvier R, Pangaud C, Lasne Y. Local control of prostate cancer by transrectal high intensity focused ultrasound therapy: preliminary results. J Urol 1999; 161:156-162.
    • (1999) J Urol , vol.161 , pp. 156-162
    • Gelet, A.1    Chapelon, J.Y.2    Bouvier, R.3    Pangaud, C.4    Lasne, Y.5
  • 22
    • 0036093264 scopus 로고    scopus 로고
    • High intensity focused ultrasound as noninvasive therapy for multilocal renal cell carcinoma: Case study and review of the literature
    • Köhrmann KU, Michel MS, Gaa J, Marlinghaus E, Alken P. High intensity focused ultrasound as noninvasive therapy for multilocal renal cell carcinoma: case study and review of the literature. J Urol 2002; 167:2397-2403.
    • (2002) J Urol , vol.167 , pp. 2397-2403
    • Köhrmann, K.U.1    Michel, M.S.2    Gaa, J.3    Marlinghaus, E.4    Alken, P.5
  • 23
    • 0037372845 scopus 로고    scopus 로고
    • MR imaging-guided focused ultrasound surgery of uterine leiomyomas: A feasibility study
    • Tempany CM, Stewart EA, McDannold N, Jolesz FA, Hynynen K. MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study. Radiology 2003; 226:897-905.
    • (2003) Radiology , vol.226 , pp. 897-905
    • Tempany, C.M.1    Stewart, E.A.2    McDannold, N.3    Jolesz, F.A.4    Hynynen, K.5
  • 24
    • 0032470386 scopus 로고    scopus 로고
    • Acoustically active lipospheres containing paclitaxel: A new therapeutic ultrasound contrast agent
    • Unger EC, McCreery TP, Sweitzer RH, Caldwell VE, Wu Y. Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest Radiol 1998; 33:886-892.
    • (1998) Invest Radiol , vol.33 , pp. 886-892
    • Unger, E.C.1    McCreery, T.P.2    Sweitzer, R.H.3    Caldwell, V.E.4    Wu, Y.5
  • 25
    • 0034749976 scopus 로고    scopus 로고
    • Intracellular drug delivery using low-frequency ultrasound: Quantification of molecular uptake and cell viability
    • Keyhani K, Guzmán HR, Parsons A, Lewis TN, Prausnitz MR. Intracellular drug delivery using low-frequency ultrasound: quantification of molecular uptake and cell viability. Pharm Res 2001; 18:1514-1520.
    • (2001) Pharm Res , vol.18 , pp. 1514-1520
    • Keyhani, K.1    Guzmán, H.R.2    Parsons, A.3    Lewis, T.N.4    Prausnitz, M.R.5
  • 26
    • 0035838377 scopus 로고    scopus 로고
    • Mechanism of ultrasonic activation of micellar drug delivery
    • Marin A, Muniruzzaman M, Rapoport N. Mechanism of ultrasonic activation of micellar drug delivery. J Control Release 2001; 75:69-81.
    • (2001) J Control Release , vol.75 , pp. 69-81
    • Marin, A.1    Muniruzzaman, M.2    Rapoport, N.3
  • 27
    • 0037020522 scopus 로고    scopus 로고
    • Ultrasonic release of doxorubicin from pluronic p105 micelles stabilized with an interpreting network of N,N-diethylacrylamide
    • Husseini GA, Christensen DA, Rapoport NY, Pitt WG. Ultrasonic release of doxorubicin from pluronic p105 micelles stabilized with an interpreting network of N,N-diethylacrylamide. J Control Release 2002; 83:303-305.
    • (2002) J Control Release , vol.83 , pp. 303-305
    • Husseini, G.A.1    Christensen, D.A.2    Rapoport, N.Y.3    Pitt, W.G.4
  • 28
    • 3042838725 scopus 로고    scopus 로고
    • Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
    • Husseini GA, Runyan CM, Pitt WG. Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles. BMC Cancer 2002; 2:20. Available at: www.biomedcentral-.com/1471-2407/2/20.
    • (2002) BMC Cancer , vol.2 , pp. 20
    • Husseini, G.A.1    Runyan, C.M.2    Pitt, W.G.3
  • 29
    • 0033693268 scopus 로고    scopus 로고
    • Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration
    • Anwer K, Kao G, Proctor B, et al. Ultrasound enhancement of cationic lipid-mediated gene transfer to primary tumors following systemic administration. Gene Ther 2000; 7:1833-1839.
    • (2000) Gene Ther , vol.7 , pp. 1833-1839
    • Anwer, K.1    Kao, G.2    Proctor, B.3
  • 30
    • 0034209640 scopus 로고    scopus 로고
    • Ultrasound enhancement of liposome-mediated cell transfection is caused by cavitation effects
    • Koch S, Pohl P, Cobet U, Rainov NG. Ultrasound enhancement of liposome-mediated cell transfection is caused by cavitation effects. Ultrasound Med Biol 2000; 26:897-903.
    • (2000) Ultrasound Med Biol , vol.26 , pp. 897-903
    • Koch, S.1    Pohl, P.2    Cobet, U.3    Rainov, N.G.4
  • 31
    • 0037115420 scopus 로고    scopus 로고
    • Ultrasonically activated chemotherapeutic drug delivery in a rat model
    • Nelson JL, Roeder BL, Carmen JC, Roloff F, Pitt WG. Ultrasonically activated chemotherapeutic drug delivery in a rat model. Cancer Res 2002; 62:7280-7283.
    • (2002) Cancer Res , vol.62 , pp. 7280-7283
    • Nelson, J.L.1    Roeder, B.L.2    Carmen, J.C.3    Roloff, F.4    Pitt, W.G.5
  • 32
    • 0030923714 scopus 로고    scopus 로고
    • In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound
    • Bednarski MD, Lee JW, Callstrom MR, Li KC. In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound. Radiology 1997; 204: 263-268.
    • (1997) Radiology , vol.204 , pp. 263-268
    • Bednarski, M.D.1    Lee, J.W.2    Callstrom, M.R.3    Li, K.C.4
  • 33
    • 17744406409 scopus 로고    scopus 로고
    • Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala
    • Arenberg DA, Keane MP, DiGiovine B, et al. Bidirectional modulation of GABA release by presynaptic glutamate receptor 5 kainate receptors in the basolateral amygdala. J Clin Invest 1998; 102:465-472.
    • (1998) J Clin Invest , vol.102 , pp. 465-472
    • Arenberg, D.A.1    Keane, M.P.2    DiGiovine, B.3
  • 34
    • 12344256144 scopus 로고
    • A versatile schlieren system for beam and waveform visualization with quantitative real-time profiling capability
    • Evans JA, ed. York, United Kingdom: Institute of Physical Sciences in Medicine
    • Follett DH. A versatile schlieren system for beam and waveform visualization with quantitative real-time profiling capability. In: Evans JA, ed. Physics in medical ultrasound. IPSM Report no. 47. York, United Kingdom: Institute of Physical Sciences in Medicine, 1986; 85-93.
    • (1986) Physics in Medical Ultrasound. IPSM Report No. 47 , pp. 85-93
    • Follett, D.H.1
  • 35
    • 0022915868 scopus 로고
    • Tumor size: Effect on monoclonal antibody uptake in tumor models
    • Hagan PL, Halpern SE, Dillman RO, et al. Tumor size: effect on monoclonal antibody uptake in tumor models. J Nucl Med 1986; 27:422-427.
    • (1986) J Nucl Med , vol.27 , pp. 422-427
    • Hagan, P.L.1    Halpern, S.E.2    Dillman, R.O.3
  • 36
    • 0032851960 scopus 로고    scopus 로고
    • An overview of monoclonal antibody therapy of cancer
    • Weiner LM. An overview of monoclonal antibody therapy of cancer. Semin Oncol 1999; 26(4 suppl 12):41-50.
    • (1999) Semin Oncol , vol.26 , Issue.4 SUPPL. 12 , pp. 41-50
    • Weiner, L.M.1
  • 37
    • 0030579707 scopus 로고    scopus 로고
    • Doxorubicin in sterically stabilized liposomes
    • Lasic DD. Doxorubicin in sterically stabilized liposomes. Nature 1996; 380:561-562.
    • (1996) Nature , vol.380 , pp. 561-562
    • Lasic, D.D.1
  • 38
  • 39
    • 0036814395 scopus 로고    scopus 로고
    • Lithotripter shock waves with cavitation nucleation agents produce tumor growth reduction and gene transfer in vivo
    • Miller DL, Song J. Lithotripter shock waves with cavitation nucleation agents produce tumor growth reduction and gene transfer in vivo. Ultrasound Med Biol 2002; 28:1343-1348.
    • (2002) Ultrasound Med Biol , vol.28 , pp. 1343-1348
    • Miller, D.L.1    Song, J.2
  • 40
    • 0028795849 scopus 로고
    • On the mechanisms of in vitro and in vivo phonophoresis
    • Simonin JP. On the mechanisms of in vitro and in vivo phonophoresis. J Control Release 1995; 33:125-141.
    • (1995) J Control Release , vol.33 , pp. 125-141
    • Simonin, J.P.1
  • 41
    • 18744420416 scopus 로고    scopus 로고
    • WFUMB Symposium on Safety of Ultrasound in Medicine: Conclusions and recommendations on thermal and non-thermal mechanisms for biological effects of ultrasound, Kloster-Banz, Germany, April 14-19, 1996
    • World Federation for Ultrasound in Medicine and Biology
    • WFUMB Symposium on Safety of Ultrasound in Medicine: conclusions and recommendations on thermal and non-thermal mechanisms for biological effects of ultrasound, Kloster-Banz, Germany, April 14-19, 1996. World Federation for Ultrasound in Medicine and Biology. Ultrasound Med Biol 1998; 24(suppl 1):i-xvi, S1-S58.
    • (1998) Ultrasound Med Biol , vol.24 , Issue.SUPPL. 1
  • 42
    • 0038048071 scopus 로고    scopus 로고
    • Tumor growth reduction and DNA transfer by cavitation-enhanced high intensity focused ultrasound in vivo
    • Miller DL, Song J. Tumor growth reduction and DNA transfer by cavitation-enhanced high intensity focused ultrasound in vivo. Ultrasound Med Biol 2003; 29:887-893.
    • (2003) Ultrasound Med Biol , vol.29 , pp. 887-893
    • Miller, D.L.1    Song, J.2
  • 43
    • 0036657984 scopus 로고    scopus 로고
    • Endothelial cell injury in venule and capillary induced by contrast ultrasonography
    • Kobayashi N, Yasu T, Yamada S, et al. Endothelial cell injury in venule and capillary induced by contrast ultrasonography. Ultrasound Med Biol 2002; 28:949-956.
    • (2002) Ultrasound Med Biol , vol.28 , pp. 949-956
    • Kobayashi, N.1    Yasu, T.2    Yamada, S.3
  • 44
    • 12344312498 scopus 로고    scopus 로고
    • Pulsed-HIFU facilitated local gene delivery with systemically injected naked DNA in a mouse squamous cell carcinoma model: Initial experience
    • in press
    • Dittmar K, Xie J, Hunter F, et al. Pulsed-HIFU facilitated local gene delivery with systemically injected naked DNA in a mouse squamous cell carcinoma model: initial experience. Radiology (in press).
    • Radiology
    • Dittmar, K.1    Xie, J.2    Hunter, F.3
  • 45
    • 0036218695 scopus 로고    scopus 로고
    • Acoustic radiation force impulse imaging: In vivo demonstration of clinical feasibility
    • Nightingale K, Soo MS, Nightingale R, Trahey G. Acoustic radiation force impulse imaging: in vivo demonstration of clinical feasibility. Ultrasound Med Biol 2002; 28:227-235.
    • (2002) Ultrasound Med Biol , vol.28 , pp. 227-235
    • Nightingale, K.1    Soo, M.S.2    Nightingale, R.3    Trahey, G.4
  • 46
    • 0344413025 scopus 로고    scopus 로고
    • Radiation-force technique to monitor lesions during ultrasonic therapy
    • Lizzi FL, Muratore R, Deng CX, et al. Radiation-force technique to monitor lesions during ultrasonic therapy. Ultrasound Med Biol 2003; 11:1593-1605.
    • (2003) Ultrasound Med Biol , vol.11 , pp. 1593-1605
    • Lizzi, F.L.1    Muratore, R.2    Deng, C.X.3
  • 48
    • 0029125922 scopus 로고
    • Ultrasound-mediated transdermal protein delivery
    • Mitragotri S, Blankschtein D, Langer R. Ultrasound-mediated transdermal protein delivery. Science 1995; 269:850-853.
    • (1995) Science , vol.269 , pp. 850-853
    • Mitragotri, S.1    Blankschtein, D.2    Langer, R.3
  • 49
    • 0034083378 scopus 로고    scopus 로고
    • Ultrasound-induced intercellular space widening in fish epidermis
    • Frenkel V, Kimmel E, Iger Y. Ultrasound-induced intercellular space widening in fish epidermis. Ultrasound Med Biol 2000; 26:473-480.
    • (2000) Ultrasound Med Biol , vol.26 , pp. 473-480
    • Frenkel, V.1    Kimmel, E.2    Iger, Y.3
  • 50
    • 0034632949 scopus 로고    scopus 로고
    • Ultrasound-facilitated transport of silver chloride (AgCl) particles in fish skin
    • Frenkel V, Kimmel E, Iger Y. Ultrasound-facilitated transport of silver chloride (AgCl) particles in fish skin. J Control Release 2000; 68:251-261.
    • (2000) J Control Release , vol.68 , pp. 251-261
    • Frenkel, V.1    Kimmel, E.2    Iger, Y.3


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