Synthesis of alkylsulfonyl and substituted benzenesulfonyl curcumin mimics as dual antagonist of L-type Ca2+ channel and endothelin A/B2 receptor

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 20, 2015, Pages 6673-6682

  Park, Chong Bin ^a   Ahn, Chan Mug ^b   Oh, Sangtae ^c   Kwon, Daeho ^c   Cho, Won Chul ^a   Shin, Woon Seob ^c   Cui, Yuan ^c   Um, Ye Sol ^c   Park, Byong Gon ^c   Lee, Seokjoon ^c  

^a University of Ulsan College of Medicine   (South Korea)

^b Yonsei University Wonju College of Medicine   (South Korea)

^c Kwandong University College of Medicine   (South Korea)

Author keywords

Curcumin; Curcumin mimic; Endothelin A B2 receptor antagonist; Endotheline 1; High potassium ion; L type Ca2+ channel blocker; Vasodilatation

Indexed keywords

1 (3 AMINOPHENYL) 3 (4 HYDROXY 3 METHOXYPHENYL)PROPENONE; 3 ACETYLANILINE; ALKYLSULFONYL GROUP; ALKYLSULFONYLAMIDE CURCUMIN DERIVATIVE; ARYLSULFONYLAMIDE CURCUMIN DERIVATIVE; BENZENESULFONYLCURCUMIN; CALCIUM CHANNEL L TYPE; CURCUMIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN B2 RECEPTOR; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENYL] 2,4 DICHLOROBENZENESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENYL] 2,6 DICHLOROBENZENESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENYL] 4 FLUOROBENZENESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENYL] 4 METHYLBENZENESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENYL] 4 NITROBENZENESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENYL] 4 TRIFLUOROMETHOXYBENZENESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENY] 4 METHOXYBENZENESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENY] 4 TRIFLUOROMETHYLBENZENESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENY]BENZENESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENY]ETHANESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENY]ISOPROPANESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENY]METHANESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENY]PROPANESULFONAMIDE; N [3 [3 (4 HYDROXY 3 METHOXYPHENYL)ACRYLOYL]PHENY]TRIFLUOROMETHANESULFONAMIDE; SULFONYLCURCUMINOID DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLIN; VASODILATOR AGENT; CALCIUM CHANNEL BLOCKING AGENT; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR ANTAGONIST;

ADDITION REACTION; ALDOL REACTION; ANIMAL CELL; ANIMAL TISSUE; ARTERY CONSTRICTION; ARTICLE; BASILAR ARTERY; BLOOD VESSEL TONE; CONCENTRATION RESPONSE; DEPOLARIZATION; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; EC50; HYPERTENSION; MALE; NONHUMAN; PROTEIN EXPRESSION; RABBIT; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SYNTHESIS; VASCULAR SMOOTH MUSCLE CELL; VASODILATATION; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN A RECEPTOR ANTAGONISTS; ENDOTHELIN B RECEPTOR ANTAGONISTS; MALE; MOLECULAR STRUCTURE; RABBITS; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84943585964     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.09.004     Document Type: Article

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