Endothelin-1 induces interleukin-6 release via activation of the transcription factor NF-κB in human vascular smooth muscle cells

Basic Research in Cardiology

Volumn 95, Issue 2, 2000, Pages 98-105

  Browatzki, Michael ^a   Schmidt, Joachim ^a   Kübler, Wolfgang ^a   Kranzhöfer, Roger ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Atherosclerosis; Cytokines; Endothelins; Free radicals; Inflammation

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; INTERLEUKIN 6; MESSENGER RNA; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; NUCLEAR FACTOR; OXYGEN RADICAL; PYRROLIDINE DITHIOCARBAMATE;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG INHIBITION; HUMAN; HUMAN CELL; INFLAMMATION; VASCULAR SMOOTH MUSCLE;

ANTIOXIDANTS; CELLS, CULTURED; ENDOTHELIN-1; HUMANS; INTERLEUKIN-6; MUSCLE, SMOOTH, VASCULAR; NF-KAPPA B; RECEPTOR, ENDOTHELIN A; RECEPTORS, ENDOTHELIN;

EID: 0034055227     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950050170     Document Type: Article

References (41)

1. Alexander RW (1994) Inflammation and coronary artery disease. N Engl J Med 331: 468-469
2. Bacon CR, Cary NRB, Davenport AP (1995) Distribution of endothelin receptors in atherosclerotic human coronary arteries. J Cardiovasc Pharmacol 26 (suppl 3): S439-S441
3. Baeuerle PA, Henkel T (1994) Function and activation of NF-κB in the immune system. Annu Rev Immunol 12: 141-179
4. Biasucci LM, Vitelli A, Liuzzo G, Altamura S, Caligiuri G, Monaco C, Rebuzzi AG, Ciliberto G, Maseri A (1996) Elevated levels of interleukin-6 in unstable angina. Circulation 94: 874-877
5. Chen XL, Tummala PE, Olbrych MT, Alexander RW, Medford RM (1998) Angiotensin II induces monocyte chemoattractant protein-1 gene expression in rat vascular smooth muscle cells. Circ Res 83: 952-959
6. A receptors pre-dominate in the human vasculature and mediate constriction. J Cardiovasc Pharmacol 26 (suppl 3): S265-S267
7. Ehrenreich H, Anderson RW, Fox CH, Rieckmann P, Hoffman GS, Travis WD, Coligan JE, Kehrl JH, Fauci AS (1990) Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J Exp Med 172: 1741-1748
8. Gallois C, Habib A, Tao J, Moulin S, Maclouf J, Mallat A, Lotersztajn S (1998) Role of NF-κB in the antiproliferative effect of endothelin-1 and tumor necrosis factor-α in human hepatic stellate cells. J Biol Chem 273: 23183-23190
9. Griendling KK, Minieri CA, Ollerenshaw JD, Alexander RW (1994) Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148
10. Haller H, Lindschau C, Erdmann B, Quass P, Luft FC (1996) Effects of intracellular angiotensin II in vascular smooth muscle cells. Circ Res 79: 765-772
11. Hirata Y, Takagi Y, Fukuda Y, Marumo F (1989) Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis 78:225-228
12. Komuro I, Kurihara H, Sugiyama T, Yoshizumi M, Takaku F, Yazaki Y (1988) Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells. FEBS Lett 238: 249-252
13. Kranzhöfer R, Clinton SK, Ishii K, Coughlin SR, Fenton JW, II, Libby P (1996) Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes. Circ Res 79: 286-294
14. Kranzhöfer R, Schmidt J, Pfeiffer CAH, Hagl S, Libby P, Kübler W (1999) Angiotensin induces inflammatory activation of human vascular smooth muscle cells. Arterioscler Thromb Vase Biol 19: 1623-1629
15. Krzesz R, Wagner AH, Cattaruzza M, Hecker M (1999) Cytokine-inducible CD40 gene expression in vascular smooth muscle cells is mediated by nuclear factor KB and signal transducer and activation of transcription-1. FEBS Lett 453: 191-196
16. Le JM, Vilcek J (1989) Interleukin 6: a multifunctional cytokine regulating immune reactions and the acute phase protein response. Lab Invest 61: 588-602
17. Lerman A, Edwards BS, Hallet JW, Heulbein DM, Sandberg SM, Burnett JC Jr (1991) Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis. N Engl J Med 325: 997-1001
18. Lerman A, Holmes DR. Bell MR, Garrat KN, Nishimura RA, Burnett JC Jr (1995) Endothelin in coronary endothelial dysfunction and early atherosclerosis in humans. Circulation 92: 2426-2431
19. Levin ER (1995) Endothelins. N Engl J Med 333: 356-363
20. Libby P (1995) Molecular bases of the acute coronary syndromes. Circulation 91: 2844-2850
21. Libby P, O'Brien KV (1983) Culture of quiescent arterial smooth muscle cells in a defined serum-free medium. J Cell Physiol 115: 217-223
22. Liberman TA, Baltimore D (1990) Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol 10: 2327-2334
23. Liuzzo G, Biasucci LM, Gallimore JR, Grillo RL, Rebuzzi AG, Pepys MB, Maseri A (1994) The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med 331: 417-424
24. Loppnow H, Libby P (1990) Proliferating or interleukin-1-activated human vascular smooth muscle cells secrete copious interleukin-6. J Clin Invest 85: 731-738
25. Matsuno M, Kozawa O, Suzuki A, Tokuda H, Kaida T, Matsuno H, Niwa M, Uematsu T (1998) Involvement of protein kinase C activation in endothelin-1-induced secretion of interleukin-6 in osteoblast-like cells. Cell Signal 10: 107-111
26. McKenna CJ, Burke SE, Opgenorth TJ, Padley RJ, Camrud LJ, Camrud AR, Johnson J, Carlson PJ, Lerman A, Holmes DR Jr, Schwartz RS (1998) Selective ETA receptor antagonism reduces neointimal hyperplasia in a porcine coronary stent model. Circulation 97: 2551-2556
27. Ohlstein EH, Arleth A, Bryan H, Elliott JD, Sung CP (1992) The selective endothelin ETA receptor antagonist BQ-123 antagonizes endothelin-1-mediated mitogenesis. Eur J Pharmacol 225: 347-350
28. Okada K, Nishida Y, Murakami H, Sugimoto I, Kosaka H, Morita H, Yamashita C, Okada M (1998) Role of endogenous endothelin in the development of graft arteriosclerosis in rat cardiac allografts. Antiproliferative effects of bosentan, a nonselective endothelin receptor antagonist. Circulation 97: 2346-2351
29. Perkins SL, Sarra JE, Kling SJ, Kohan DE (1997) Endothelin stimulates osteoblastic production of IL-6 but not macrophage colony-stimulating factor. Am J Physiol 272: E461-E468
30. Resink TJ, Hahn AW, Scott-Burden T, Powell J, Weber E, Bühler FR (1990) Inducible endothelin mRNA expression and peptide secretion in cultured human vascular smooth muscle cells. Biochem Biophys Res Commun 168: 1303-1310
31. Ross R (1999) Mechanisms of disease: atherosclerosis - an inflammatory disease. N Engl J Med 340: 115-126
32. Satriano JA, Shuldiner M, Hora K, Xing Y, Schlondorff D (1993) Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/ MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-α and immunoglobulin G. J Clin Invest 92: 1564-1571
33. Schiffrin EL (1995) Endothelin, potential role in hypertension and vascular hypertrophy. Hypertension 25: 1135-1143
34. Schreck R, Rieber P, Bauerle PA (1991) Reactive oxygen intermediates as widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J 10: 2247-2258
35. Speciale L, Roda K, Saresella M, Taramelli D, Ferrante P (1998) Different endothelins stimulate cytokine production by peritoneal macrophages and microglial cell line. Immunology 93: 109-114
36. Sumner MJ, Cannon TR, Mundin JW, White DG, Watts IS (1992) Endothelin ETA and ETB receptors mediate vascular smooth muscle contraction. Br J Pharmacol 107: 858-860
37. Tsukada T, McNutt MA, Ross R, Gown AM (1987) HHF35, a muscle actin-specinc monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues. Am J Pathol 127: 389-402
38. van der Wal AC, Becker AE, van der Loos CM, Das PK (1994) Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 89: 36-44
39. Wang Y, Rose PM, Webb ML, Dunn MJ (1994) Endothelins stimulate mitogen-activated protein kinase cascade through either ETA or ETB. Am J Physiol 267: C1130-C1135
40. Zeiher AM, Göber H, Schächinger V, Ihling C (1995) Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque: a clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina. Circulation 91: 941-947
41. Zeiher AM, Ihling C, Pistorius K, Schächinger V, Schäfer HE (1994) Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes. Lancet 344: 1405-1406