Riboswitch-mediated Attenuation of Transgene Cytotoxicity Increases Adeno-associated Virus Vector Yields in HEK-293 Cells

Molecular Therapy

Volumn 23, Issue 10, 2015, Pages 1582-1591

  Strobel, Benjamin ^a   Klauser, Benedikt ^b   Hartig, Jörg S ^b   Lamla, Thorsten ^a   Gantner, Florian ^a   Kreuz, Sebastian ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE; TRANSCRIPTION FACTOR; VIRUS VECTOR; LIGAND; RIBOSWITCH;

ADENO ASSOCIATED VIRUS; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; ATTENUATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION; GENE FUNCTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNODETECTION; IN VIVO STUDY; LIGAND BINDING; LUNG FIBROSIS; MAMMAL CELL; ONCOLYTIC VIROTHERAPY; PROMOTER REGION; RIBOSWITCH; TRANSGENE; UNTRANSLATED REGION; VIRUS REPLICATION; ANIMAL; DEPENDOPARVOVIRUS; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENE ORDER; GENE VECTOR; GENETIC TRANSDUCTION; GENETICS; METABOLISM; MOUSE; REPORTER GENE;

ANIMALS; DEPENDOVIRUS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE ORDER; GENES, REPORTER; GENETIC VECTORS; GUANINE; HEK293 CELLS; HUMANS; LIGANDS; MICE; RIBOSWITCH; TRANSDUCTION, GENETIC; TRANSGENES; VIRUS REPLICATION;

EID: 84943581450     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2015.123     Document Type: Article

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