Addition of N-glycosylation sites on the globular head of the H5 hemagglutinin induces the escape of highly pathogenic avian influenza A H5N1 viruses from vaccine-induced immunity

Virology

Volumn 486, Issue , 2015, Pages 134-145

  Hervé, Pierre Louis ^a,b,c,e   Lorin, Valérie ^a,b,c,d   Jouvion, Grégory ^d   Da Costa, Bruno ^e   Escriou, Nicolas ^a,b,c,d  

^a Sorbonne Paris Cité   (France)

^b Institut Pasteur   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d INSTITUT PASTEUR   (France)

^e INRA Institut National de la Recherche Agronomique   (France)

Author keywords

Antigenic drift; Hemagglutinin H5; Highly pathogenic Influenza A H5N1; N glycosylation; Neutralizing antibodies

Indexed keywords

INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; NEUTRALIZING ANTIBODY; HEMAGGLUTININ, AVIAN INFLUENZA A VIRUS; VIRUS ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; FEMALE; GLYCOSYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA A (H5N1); INFLUENZA A VIRUS (H3N2); INFLUENZA A VIRUS (H5N1); MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; VIRUS ESCAPE; VIRUS IMMUNITY; VIRUS MUTANT; VIRUS NEUTRALIZATION; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; EPITOPE MAPPING; GENETICS; IMMUNOLOGY; INFLUENZA; METABOLISM; PROTEIN MOTIF; SERODIAGNOSIS; VIROLOGY;

AMINO ACID MOTIFS; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; EPITOPE MAPPING; FEMALE; GLYCOSYLATION; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA VACCINES; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; NEUTRALIZATION TESTS;

EID: 84943411448     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2015.08.033     Document Type: Article

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