N-linked glycosylation of the hemagglutinin protein influences virulence and antigenicity of the 1918 pandemic and seasonal H1N1 influenza A viruses

Journal of Virology

Volumn 87, Issue 15, 2013, Pages 8756-8766

  Sun, Xiangjie ^a   Jayaraman, Akila ^c   Maniprasad, Pavithra ^c   Raman, Raman ^c   Houser, Kathrine ^a,b   Pappas, Claudia ^a   Zeng, Hui ^a   Sasisekharan, Ram ^c   Katz, Jacqueline ^a   Tumpey, Terrence M ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b EMORY UNIVERSITY   (United States)

^c Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VIRUS HEMAGGLUTININ;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTIGENICITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; CROSS REACTION; EMBRYO; FEMALE; HEMAGGLUTINATION INHIBITION; HUMAN; HUMAN CELL; INFLUENZA VIRUS A H1N1; MDCK CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN TRANSPORT; RECEPTOR BINDING; SEASONAL INFLUENZA; SITE DIRECTED MUTAGENESIS; SPANISH INFLUENZA; STRAIN IDENTIFICATION; STRUCTURE ANALYSIS; VIROGENESIS; VIRUS DETECTION; VIRUS HEMAGGLUTINATION; VIRUS NEUTRALIZATION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE; WEIGHT REDUCTION;

ANIMALS; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CROSS REACTIONS; DISEASE MODELS, ANIMAL; DNA MUTATIONAL ANALYSIS; FEMALE; GLYCOSYLATION; HEMAGGLUTINATION INHIBITION TESTS; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; ORTHOMYXOVIRIDAE INFECTIONS; VIRULENCE FACTORS;

EID: 84880260784     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00593-13     Document Type: Article

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