Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents

Oncotarget

Volumn 6, Issue 27, 2015, Pages 24277-24290

  Zhang, Yun Kai ^a   Zhang, Hengyuan ^b   Zhang, Guan Nan ^a   Wang, Yi Jun ^a   Kathawala, Rishil J ^a   Si, Rui ^a   Patel, Bhargav A ^a   Xu, Jinyi ^b   Chen, Zhe Sheng ^a  

^a ST JOHN'S UNIVERSITY   (United States)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

ABC transporter; ABCB1; Ginsenoside; Multidrug resistance; Ocotillol type triterpenoid derivatives

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AMINE; EPOXY 12BETA, 25 DIHYDROXYDOMMARANE 3BETA AMINE; MULTIDRUG RESISTANCE PROTEIN 1; OCOTILLOL DERIVATIVE; PACLITAXEL; UNCLASSIFIED DRUG; VERAPAMIL; VINCRISTINE; ABC TRANSPORTER; ABCB1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 3A; GINSENOSIDE; MULTIDRUG RESISTANCE PROTEIN; OCOTILLOL;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ANTAGONISM; ENZYME ACTIVITY; EPIMER; GENE FUNCTION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MOLECULAR DOCKING; ONCOGENE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; HEK293 CELL LINE; METABOLISM; MOLECULAR MODEL; MULTIDRUG RESISTANCE; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATASES; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; COMPUTER SIMULATION; CYTOCHROME P-450 CYP3A; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GINSENOSIDES; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; P-GLYCOPROTEINS; PACLITAXEL; VINCRISTINE;

EID: 84943376704     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4493     Document Type: Article

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