Synthesis and biological evaluation of novel ocotillol-type triterpenoid derivatives as antibacterial agents

European Journal of Medicinal Chemistry

Volumn 68, Issue , 2013, Pages 444-453

  Zhou, Zhiwen ^a   Ma, Cong ^b   Zhang, Hengyuan ^a   Bi, Yi ^a   Chen, Xia ^a   Tian, Hua ^a   Xie, Xiaoni ^a   Meng, Qingguo ^c   Lewis, Peter John ^b   Xu, Jinyi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c YANTAI UNIVERSITY   (China)

Author keywords

Antibacterial activity; Cytotoxicity; Ocotillol; Synergistic effect; Triterpenoid

Indexed keywords

23 HYDROXYBETULINIC ACID; ANTIINFECTIVE AGENT; BETULIC ACID; CHLORAMPHENICOL; EPOXY 12BETA O (2 CARBOXY BENZOYL)DAMMARANE 3BETA,25 DIOL; EPOXY 12BETA O ACETYL DAMMARANE 3BETA,25 DIOL; EPOXY 12BETA O CINNAMOYL DAMMARANE 3BETA,25 DIOL; EPOXY 12BETA,25 DIHYDROXY DAMMARANE 3 ONE; EPOXY 25 HYDROXY DAMMARANE 3,12 DIONE; EPOXY 3BETA,25 DIHYDROXY DAMMARANE 12 ONE; EPOXY DAMMARANE 3BETA,12BETA,25 TRIOL; KANAMYCIN; PROTOPANAXADIOL; TRITERPENOID; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL; BACTERIAL STRAIN; BIOLOGICAL ACTIVITY; CELL ASSAY; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENTIATION; DRUG SYNTHESIS; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ANTIBACTERIAL ACTIVITY; CYTOTOXICITY; OCOTILLOL; SYNERGISTIC EFFECT; TRITERPENOID;

ANTI-BACTERIAL AGENTS; BACTERIA; CELL SURVIVAL; GINSENOSIDES; HEK293 CELLS; HELA CELLS; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84883061765     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.07.041     Document Type: Article

References (31)

1. R.E.H. Hancock Lancet Infect. Dis. 5 2005 209 218
2. R. Laxminarayan, A. Malani, D. Howard, and D.L. Smith Extending the Cure: Policy Responses to the Growing Threat of Antibiotic Resistance 2007 Resources for the Future Washington, DC
3. J.L. Raygada, and D.P. Levine Infect. Med. 26 2009 49 58
4. B.P. Howden, J.K. Davies, P.D. Johnson, T.P. Stinear, and M.L. Grayson Clin. Microbiol. Rev. 23 2010 99 139
5. D.J. Newman, and G.M. Cragg J. Nat. Prod. 70 2007 461 477
6. A.L. Harvey Drug Discovery Today 13 2008 19 20
7. B. Wilkinson, and J. Micklefield Nat. Chem. Biol. 3 2007 379 386
8. R. Xu, Z.C. Fazio, and S.P.T. Matsuda Phytochemistry 65 2004 261 291
9. M.A. Collins, and H.P. Charles Food Microbiol. 4 1987 311 315
10. S. Wechesser, K. Engel, B. Simon-Haarhaus, A. Wittmer, K. Pelz, and C.M. Schempp Phytomedicine 14 2007 508 516
11. J.C.P. Steele, D.C. Warhurst, G.C. Kirby, and M.S.J. Simmonds Phytother. Res. 13 1999 115 119
12. A. Nick, A.D. Wright, T. Rali, and O. Sticher Phytochemistry 40 1995 1691 1695
13. K. Horiuchi, S. Shiota, T. Hatana, T. Yoshida, T. Kuroda, and T. Tsuchiya Biol. Pharm. Bull. 30 2007 1147 1149
14. S. Fontanay, M. Grare, J. Mayer, C. Finance, and R.E. Duval J. Ethnopharmacol. 120 2008 272 276
15. M.S. Butler, and A.D. Buss Biochem. Pharmacol. 71 2006 919 929
16. E.W. Warnhoff, and C.M.M. Halls Can. J. Chem. 43 1965 3311 3321
17. O. Tanaka, and S. Yahara Phytochemistry 17 1978 1353 1358
18. A.S. Attele, J.A. Wu, and C.S. Yuan Biochem. Pharmacol. 58 1999 1685 1693
19. A.B. Wang, C.Z. Wang, J.A. Wu, J. Osinski, and C.S. Yuan Phytochem. Anal. 16 2005 272 277
20. J.M. Augustin, V. Kuzina, S.B. Andersen, and S. Bak Phytochemistry 72 2011 435 457
21. M.F. Melzig, G. Bader, and R. Loose Planta Med. 67 2001 43 48
22. J. Liu, J. Shiono, K. Shimizu, H. Yu, C. Zhang, F. Jin, and R. Kondo Bioorg. Med. Chem. Lett. 19 2009 3320 3323
23. D. Lu, J. Liu, W. Zhao, and P. Li J. Ethnopharmacol. 144 2012 656 663
24. Y. Bi, J.W. Tian, L. Wang, F.L. Zhao, J.F. Zhang, N. Wang, H.J. Sun, and Q.G. Meng J. Med. Plants Res. 5 2011 2424 2429
25. F. Seiji, K. Ryoji, O. Kazuhiro, Y. Kazuo, M.H. Chiu, R.L. Nie, and T. Osamu Phytochemistry 39 1995 591 602
26. C.L. Maree, R.S. Daum, S. Boyle-Vavra, K. Matayoshi, and L.G. Miller Emerg. Infect. Dis. 13 2007 236 242
27. J.L. Burns, P.M. Mendelman, J. Levy, T.L. Stull, and A.L. Smith Antimicrob. Agents Chemother. 27 1985 46 54
28. B.C.L. Chan, M. Ip, H. Gong, S.L. Lui, and R.H. See Phytomedicine 20 2013 611 614
29. A.H. Delcour Biochim. Biophys. Acta 1794 2009 808 816
30. P.G. Mortimer, and L.J. Piddock J. Antimicrob. Chemother. 32 1993 195 213
31. G.J. Du, Q. Dai, S. Williams, C.Z. Wang, and C.S. Yuan Anticancer Drugs 22 2011 35 45