Transplantation of adipose tissue mesenchymal cells conjugated with VEGF-releasing microcarriers promotes repair in murine myocardial infarction

Cardiovascular Research

Volumn 108, Issue 1, 2015, Pages 39-49

  Madonna, Rosalinda ^a   Petrov, Lyubomir ^b   Teberino, Maria Anna ^a   Manzoli, Lamberto ^a   Karam, Jean Pierre ^c   Renna, Francesca Vera ^a   Ferdinandy, Peter ^d   Montero Menei, Claudia N ^c   Ylä Herttuala, Seppo ^b   De Caterina, Raffaele ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c UNIVERSITÉ D'ANGERS   (France)

^d SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Adipose tissue derived mesenchymal stromal cells; Microspheres; Myocardial infarction

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; KI 67 ANTIGEN; MICROSPHERE; POLYGLACTIN; VASCULOTROPIN; VASCULOTROPIN A;

ACUTE HEART INFARCTION; ADIPOSE TISSUE MESENCHYMAL STROMAL CELL TRANSPLANTATION; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELL THERAPY; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOFLUORESCENCE; MALE; MESENCHYMAL STROMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING; ADIPOSE TISSUE; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; MESENCHYMAL STEM CELL TRANSPLANTATION; MYOCARDIAL INFARCTION; SECRETION (PROCESS);

ADIPOSE TISSUE; ANIMALS; CELLS, CULTURED; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MICE; MICE, INBRED C57BL; MICROSPHERES; MYOCARDIAL INFARCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84943368819     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvv197     Document Type: Article

References (16)

1. MERIT-HF Study Group. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet 1999; 353: 2001-2007
2. Marban E. Big cells, little cells, stem cells: agents of cardiac plasticity. Circ Res 2007; 100: 445-446
3. Delcroix GJ, Garbayo E, Sindji L, Thomas O, Vanpouille-Box C, Schiller PC, Montero-Menei CN. The therapeutic potential of human multipotent mesenchymal stromal cells combined with pharmacologically active microcarriers transplanted in hemi-parkinsonian rats. Biomaterials 2011; 32: 1560-1573
4. Madonna R, De Caterina R. Stem cells and growth factor delivery systems for cardiovascular disease. J Biotechnol 2011; 154: 291-297
5. Madonna R, Taylor DA, Geng YJ, De Caterina R, Shelat H, Perin EC, Willerson JT. Transplantation of mesenchymal cells rejuvenated by the overexpression of telomerase and myocardin promotes revascularization and tissue repair in a murine model of hindlimb ischemia. Circ Res 2013; 113: 902-914
6. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25: 581-611
7. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001; 7: 211-228
8. Penna C, Perrelli MG, Karam JP, Angotti C, Muscari C, Montero-Menei CN, Pagliaro P. Pharmacologically active microcarriers influence VEGF-A effects on mesenchymal stem cell survival. J Cell Mol Med 2013; 17: 192-204
9. Karam JP, Muscari C, Sindji L, Bastiat G, Bonafe F, Venier-Julienne MC, Montero-Menei NC. Pharmacologically active microcarriers associated with thermosensitive hydrogel as a growth factor releasing biomimetic 3D scaffold for cardiac tissue-engineering. J Control Release 2014; 192: 82-94
10. Madonna R, Delli Pizzi S, Di Donato L, Mariotti A, Di Carlo L, DUgo E, Teberino MA, Merla A, Tartaro A, De Caterina R. Non-invasive in vivo detection of peripheral limb ischemia improvement in the rat after adipose tissue-derived stromal cell transplantation. Circ J 2013; 76: 1517-1525
11. Wu KH, Mo XM, Han ZC, Zhou B. Stem cell engraftment and survival in the ischemic heart. Ann Thorac Surg 2011; 92: 1917-1925
12. Gnecchi M, He H, Liang OD, Melo LG, Morello F, Mu H, Noiseux N, Zhang L, Pratt RE, Ingwall JS, Dzau VJ. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 2005; 11: 367-368
13. Lee WY, Wei HJ, Wang JJ, Lin KJ, Lin WW, Chen DY, Huang CC, Lee TY, Ma HY, Hwang SM, Chang Y, Sung HW. Vascularization and restoration of heart function in rat myocardial infarction using transplantation of human cbMSC/HUVEC core-shell bodies. Biomaterials 2012; 33: 2127-2136
14. Madonna R, Rokosh G, De Caterina R, Bolli R. Hepatocyte growth factor/Met gene transfer in cardiac stem cells-potential for cardiac repair. Basic Res Cardiol 2010; 105: 443-452
15. Xie Y, Ibrahim A, Cheng K, Wu Z, Liang W, Malliaras K, Sun B, Liu W, Shen D, Cho HC, Li T, Lu L, Lu G, Marban E. Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells. Stem Cells 2014; 32: 2397-2406
16. Menei P, Montero-Menei C, Venier MC, Benoit JP. Drug delivery into the brain using poly(lactide-co-glycolide) microspheres. Expert Opin Drug Deliv 2005; 2: 363-376