Importance of cell-cell contact in the therapeutic benefits of cardiosphere-derived cells

Stem Cells

Volumn 32, Issue 9, 2014, Pages 2397-2406

  Xie, Yucai ^a,b   Ibrahim, Ahmed ^a   Cheng, Ke ^a   Wu, Zhijun ^b   Liang, Wenbin ^a   Malliaras, Konstantinos ^a   Sun, Baiming ^a   Liu, Weixin ^a   Shen, Deliang ^a,c   Cheol Cho, Hee ^a   Li, Taosheng ^a   Lu, Lin ^b   Lu, Guoping ^b   Marban E ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

Cardiomyocyte; Cardiosphere derived cells; Cell cell communication; Paracrine factors; Proliferation; 1 integrin

Indexed keywords

BETA1 INTEGRIN; BROXURIDINE; KI 67 ANTIGEN; NEUTRALIZING ANTIBODY; PROTEIN INHIBITOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOSPHERE DERIVED CELL; CELL COMMUNICATION; CELL CULTURE; CELL GROWTH; CELL INTERACTION; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CELL TRANSPLANTATION; CELL TYPE; COCULTURE; CONTROLLED STUDY; CYCLING; HEART INFARCTION; HEART MUSCLE CELL; HEART VENTRICLE FUNCTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; MUSCLE CELL; NONHUMAN; PARACRINE SIGNALING; PUMP; RAT; SCID MOUSE; SIGNAL TRANSDUCTION; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; HEART MUSCLE; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD29; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; HUMANS; MALE; MICE; MICE, SCID; MYOCARDIUM; MYOCYTES, CARDIAC; RATS;

EID: 84906278987     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.1736     Document Type: Article

References (39)

1. Bergmann O, Bhardwaj RD, Bernard S, et al. Evidence for cardiomyocyte renewal in humans. Science 2009; 324: 98-102.
2. Malliaras K, Zhang Y, Seinfeld J, et al. Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart. EMBO Mol Med 2013; 5: 191-209.
3. Senyo SE, Steinhauser ML, Pizzimenti CL, et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 2013; 493: 433-436.
4. Robey TE, Saiget MK, Reinecke H, Murry CE,. Systems approaches to preventing transplanted cell death in cardiac repair. J Mol Cell Cardiol 2008; 45: 567-581.
5. Loffredo FS, Steinhauser ML, Gannon J, et al. Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell 2011; 8: 389-398.
6. Hatzistergos KE, Quevedo H, Oskouei BN, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res 2010; 107: 913-922.
7. Bersell K, Arab S, Haring B, et al. Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 2009; 138: 257-270.
8. Kuhn B, del Monte F, Hajjar RJ, et al. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat Med 2007; 13: 962-969.
9. Cheng K, Shen D, Smith J, et al. Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction. Biomaterials 2012; 33: 2872-2879.
10. Malliaras K, Li TS, Luthringer D, et al. Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells. Circulation 2012; 125: 100-112.
11. Makkar RR, Smith RR, Cheng K, et al. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): A prospective, randomised phase 1 trial. Lancet 2012; 379: 895-904.
12. Liu J, Narsinh KH, Lan F, et al. Early stem cell engraftment predicts late cardiac functional recovery: Preclinical insights from molecular imaging. Circ Cardiovasc Imaging 2012; 5: 481-490.
13. Smith RR, Barile L, Cho HC, et al. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 2007; 115: 896-908.
14. Kapoor N, Galang G, Marban E, Cho HC,. Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes. J Biol Chem 2011; 286: 14073-14079.
15. Ieda M, Tsuchihashi T, Ivey KN, et al. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell 2009; 16: 233-244.
16. Liang W, Oudit GY, Patel MM, et al. Role of phosphoinositide 3-kinase {alpha}, protein kinase C, and L-type Ca2+ channels in mediating the complex actions of angiotensin II on mouse cardiac contractility. Hypertension 2010; 56: 422-429.
17. Ashikaga H, Mickelsen SR, Ennis DB, et al. Electromechanical analysis of infarct border zone in chronic myocardial infarction. Am J Physiol Heart Circ Physiol 2005; 289: H1099-1105.
18. Tseliou E, Pollan S, Malliaras K, et al. Allogeneic cardiospheres safely boost cardiac function and attenuate adverse remodeling after myocardial infarction in immunologically mismatched rat strains. J Am Coll Cardiol 2013; 61: 1108-1119.
19. Xie Y, Yin T, Wiegraebe W, et al. Detection of functional haematopoietic stem cell niche using real-time imaging. Nature 2009; 457: 97-101.
20. Streuli CH, Akhtar N,. Signal co-operation between integrins and other receptor systems. Biochem J 2009; 418: 491-506.
21. Shai SY, Harpf AE, Babbitt CJ, et al. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. Circ Res 2002; 90: 458-464.
22. Guo W, Giancotti FG,. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004; 5: 816-826.
23. Li TS, Cheng K, Malliaras K, et al. Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol 2012; 59: 942-953.
24. Chimenti I, Smith RR, Li TS, et al. Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res 2010; 106: 971-980.
25. Burt RK, Chen YH, Verda L, et al. Mitotically inactivated embryonic stem cells can be used as an in vivo feeder layer to nurse damaged myocardium after acute myocardial infarction: A preclinical study. Circ Res 2012; 111: 1286-1296.
26. Jing D, Fonseca AV, Alakel N, et al. Hematopoietic stem cells in co-culture with mesenchymal stromal cells-Modeling the niche compartments in vitro. Haematologica 2010; 95: 542-550.
27. Schreiber TD, Steinl C, Essl M, et al. The integrin alpha9beta1 on hematopoietic stem and progenitor cells: Involvement in cell adhesion, proliferation and differentiation. Haematologica 2009; 94: 1493-1501.
28. Rowland TJ, Miller LM, Blaschke AJ, et al. Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin. Stem Cells Dev 2010; 19: 1231-1240.
29. Li TS, Cheng K, Lee ST, et al. Cardiospheres recapitulate a niche-like microenvironment rich in stemness and cell-matrix interactions, rationalizing their enhanced functional potency for myocardial repair. Stem Cells 2010; 28: 2088-2098.
30. Cheng K, Li TS, Malliaras K, et al. Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction. Circ Res 2010; 106: 1570-1581.
31. White AJ, Smith RR, Matsushita S, et al. Intrinsic cardiac origin of human cardiosphere-derived cells. Eur Heart J 2013; 34: 68-75.
32. Davis DR, Kizana E, Terrovitis J, et al. Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol 2010; 49: 312-321.
33. Davis DR, Zhang Y, Smith RR, et al. Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One 2009; 4: e7195.
34. Smart N, Bollini S, Dube KN, et al. De novo cardiomyocytes from within the activated adult heart after injury. Nature 2011; 474: 640-644.
35. Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003; 114: 763-776.
36. Zhang Y, Li TS, Lee ST, et al. Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One 2010; 5: e12559.
37. Stastna M, Chimenti I, Marban E, et al. Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Proteomics 2010; 10: 245-253.
38. Malliaras K, Ibrahim A, Tseliou E, et al. Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction. EMBO Mol Med 2014 May 5. pii: emmm.201303626v1. doi: 10.1002/emmm.201303626. [Epub ahead of print]
39. Ibrahim AG, Cheng K, Marbán E., Exosomes as critical agents of cardiac regeneration triggered by cell therapy. Stem Cell Reports 2014; 2: 606-619.