The cortisol paradox of trauma-related disorders: Lower phasic responses but higher tonic levels of cortisol are associated with sexual abuse in childhood

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Schalinski, Inga ^a   Elbert, Thomas ^a   Steudte Schmiedgen, Susann ^b   Kirschbaum, Clemens ^b  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE;

ADOLESCENT; ADULT; ARTICLE; BLOOD PRESSURE; CHILD SEXUAL ABUSE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; HAIR LEVEL; HEART RATE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LIFE STRESS; MENTAL DISEASE; POSTTRAUMATIC STRESS DISORDER; SALIVA LEVEL; CHEMISTRY; CHILD; COMPARATIVE STUDY; ETHNOLOGY; GERMANY; HAIR; MENTAL STRESS; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; PSYCHOLOGICAL INTERVIEW; PSYCHOLOGY; SALIVA; STANDARDS; YOUNG ADULT;

ADOLESCENT; ADULT; BLOOD PRESSURE; CHILD; CHILD ABUSE, SEXUAL; FEMALE; GERMANY; HAIR; HEART RATE; HUMANS; HYDROCORTISONE; INTERVIEW, PSYCHOLOGICAL; MIDDLE AGED; SALIVA; STRESS, PSYCHOLOGICAL; YOUNG ADULT;

EID: 84943279701     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136921     Document Type: Article

References (55)

1. Shea A, Walsh C, Macmillan H, Steiner M. Child maltreatment and HPA axis dysregulation: relationship to major depressive disorder and post traumatic stress disorder in females. Psychoneuroendocrinology. 2005;30:162-178. PMID: 15471614
2. Meewisse ML, Reitsma JB, De Vries GJ, Gersons BP, Olff M. Cortisol and post-traumatic stress disorder in adults Systematic review and meta-analysis. Brit J Psychiatry. 2007;191:387-392.
3. Miller GE, Chen E, Zhou ES. If it goes up, must it come down? Chronic stress and the hypothalamicpituitaryadrenocortical axis in humans. Psychol Bull. 2007;133:25-45. PMID: 17201569
4. Frodl T, O'Keane V. How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiol Dis. 2013;52:24-37. doi: 10.1016/j.nbd.2012.03.012 PMID: 22426398
5. de Kloet CS, Vermetten E, Geuze E, Kavelaars A, Heijnen CJ, Westenberg HGM. Assessment of HPAaxis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J Psychiat Res. 2006;40:550-567. PMID: 16214171
6. Dickerson SS, Kemeny ME. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol Bull. 2004;130:355-391. PMID: 15122924
7. Eckart C, Engler H, Riether C, Kolassa S, Elbert T, Kolassa IT. No PTSD-related differences in diurnal cortisol profiles of genocide survivors. Psychoneuroendocrinology. 2009;34:523-531. doi: 10.1016/j. psyneuen. 2008.10.012 PMID: 19054622
8. Stalder T, Kirschbaum C. Analysis of cortisol in hair-State of the art and future directions. Brain Behav Immun. 2012;26:1019-1029. doi: 10.1016/j.bbi.2012.02.002 PMID: 22366690
9. Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA. 2000;284:592-597. PMID: 10918705
10. Korte SM, Koolhaas JM, Wingfield JC, McEwen BS. The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. Neurosci Biobehav Rev. 2005;29:3-38. PMID: 15652252
11. Meaney MJ, Szyf M. Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues Clin Neurosci. 2005;7:103-123. PMID: 16262207
12. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonté B, Szyf M, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci. 2009;12:342-348. doi: 10.1038/nn. 2270 PMID: 19234457
13. Bremner JD, Vythilingam M, Vermetten E, Adil J, Khan S, Nazeer A, et al. Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology. 2003;28:733-750. PMID: 12812861
14. Elzinga BM, Schmahl CG, Vermetten E, van Dyck R, Bremner JD. Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology. 2003;28:1656-1665. PMID: 12838270
15. Carpenter LL, Shattuck TT, Tyrka AR, Geracioti TD, Price LH. Effect of childhood physical abuse on cortisol stress response. J Psychopharmacol. 2011;214:367-375.
16. Zaba M, Kirmeier T, Ionescu IA, Wollweber B, Buell DR, Gall-Kleebach DJ, et al. Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients. Psychoneuroendocrinology. 2015;55:102-115. doi: 10.1016/j.psyneuen. 2015.02.005 PMID: 25745955
17. Lovallo WR, Farag NH, Sorocco KH, Cohoon AJ, Vincent AS. Lifetime adversity leads to blunted stress axis reactivity: studies from the Oklahoma Family Health Patterns Project. Biol Psychiatry. 2012;71:344-349. doi: 10.1016/j.biopsych.2011.10.018 PMID: 22112928
18. Steudte S, Kirschbaum C, Gao W, Alexander N, Schönfeld S, Hoyer J, et al. Hair cortisol as a biomarker of traumatization in healthy individuals and posttraumatic stress disorder patients. Biol Psychiatry. 2013;74:639-646. doi: 10.1016/j.biopsych.2013.03.011 PMID: 23623187
19. Hinkelmann K, Muhtz C, Dettenborn L, Agorastos A, Wingenfeld K, Spitzer C, et al. Association between childhood trauma and low hair cortisol in depressed patients and healthy control subjects. Biol Psychiatry. 2013;74:e15-7. doi: 10.1016/j.biopsych.2013.04.021 PMID: 23726317
20. Steudte S, Kolassa IT, Stalder T, Pfeiffer A, Kirschbaum C, Elbert T. Increased cortisol concentrations in hair of severely traumatized Ugandan individuals with PTSD. Psychoneuroendocrinology. 2011;36:1193-1200. doi: 10.1016/j.psyneuen. 2011.02.012 PMID: 21411229
21. Steudte-Schmiedgen S, Stalder T, Schönfeld S, Wittchen HU, Trautmann S, Alexander N. Hair cortisol concentrations and cortisol stress reactivity predict PTSD symptom increase after trauma exposure during military deployment. Psychoneuroendocrinology. 2015;59:123-133. doi: 10.1016/j.psyneuen. 2015.05.007 PMID: 26072152
22. De Bellis MD, Chrousos GP, Dorn LD, Burke L, Helmers K, Kling MA, et al. Hypothalamic-pituitaryadrenal axis dysregulation in sexually abused girls. J Clin Endocrinol Metab. 1994;78:249-255. PMID: 8106608
23. Lang PJ, Davis M, Öhman A. Fear and anxiety: animal models and human cognitive psychophysiology. J Affect Disord. 2000;61:137-159. PMID: 11163418
24. Schauer M, Elbert T. Dissociation following traumatic stress: etiology and treatment. J Psychol. 2010;218:109-127.
25. Griffin MG, Resick PA, Mechanic MB. Objective assessment of peritraumatic dissociation: psychophysiological indicators. Am J Psych. 1997;154:1081-1088.
26. Fagundes CP, Glaser R, Kiecolt-Glaser JK. Stressful early life experiences and immune dysregulation across the lifespan. Brain Behav Immun. 2013;27:8-12. doi: 10.1016/j.bbi.2012.06.014 PMID: 22771426
27. Slopen N, McLaughlin KA, Dunn EC, Koenen KC. Childhood adversity and cell-mediated immunity in young adulthood: Does type and timing matter?. Brain Behav Immun. 2013;28:63-71. doi: 10.1016/j. bbi.2012.10.018 PMID: 23108062
28. Gola H, Engler H, Schauer M, Adenauer H, Riether C, Kolassa S, et al. Victims of rape show increased cortisol responses to trauma reminders: A study in individuals with war- and torture-related PTSD. Psychoneuroendocrinology. 2012;37:213-220. doi: 10.1016/j.psyneuen. 2011.06.005 PMID: 21723669
29. Heidt JM, Marx BP, Forsyth JP. Tonic immobility and childhood sexual abuse: a preliminary report evaluating the sequela of rape-induced paralysis. Behav Res Ther. 2005;43:1157-1171. PMID: 16005703
30. Lang PJ. The cognitive psychophysiology of emotion: Fear and anxiety. In: Tuma A, Maser J, editors. Anxiety and the anxiety disorders, Hillsdale, NJ: Erlbaum; 1985. pp. 131-170.
31. Schalinski I, Schauer M, Elbert T. The Shutdown dissociation scale (Shut-D). Eur J Psychotraumatol. 2015;6.
32. Gray MJ, Litz BT, Hsu JL, Lombardo TW. Psychometric properties of the life events checklist. Assessment. 2004;11:330-341. PMID: 15486169
33. Heim C. Deutsche Version des Early Trauma Inventory: Inventar zur Erfassung früher traumatischer Lebensereignisse (IFTL). Unpublished Manuscript, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta. GA, USA. 2000.
34. Wingenfeld K, Driessen M, Mensebach C, Rullkoetter N, Schaffrath C, Spitzer C, et al. Die deutsche Version des "Early Trauma Inventory" (ETI). Diagnostica. 2011;57:27-38.
35. Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, et al. The development of a clinician-administered PTSD scale. J Trauma Stress. 1995;8:75-90. PMID: 7712061
36. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. The Mini-International Neuropsychiatric Interview (M. I. N. I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59:22-33.
37. Williams JB. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry. 1998;45:742-747.
38. Miller R, Plessow F, Kirschbaum C, Stalder T. Classification criteria for distinguishing cortisol responders from nonresponders to psychosocial stress: evaluation of salivary cortisol pulse detection in panel designs. Psychosom Med. 2013;75:832-840. doi: 10.1097/PSY.0000000000000002 PMID: 24184845
39. Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology. 2003;28:916-931. PMID: 12892658
40. Wosu AC, Gelaye B, Valdimarsdóttir U, Kirschbaum C, Stalder T, Shields AE, et al. Hair cortisol in relation to sociodemographic and lifestyle characteristics in a multiethnic US sample. Ann Epidemiol. 2014;25:90-95. doi: 10.1016/j.annepidem.2014.11.022 PMID: 25534254
41. Loussouarn G. African hair growth parameters. Br J Dermatol. 2001;145:294-297. PMID: 11531795
42. Hamel AF, Meyer JS, Henchey E, Dettmer AM, Suomi SJ, Novak MA. Effects of shampoo and water washing on hair cortisol concentrations. Clin Chim Acta. 2011;412:382-385. doi: 10.1016/j.cca.2010. 10.019 PMID: 21034727
43. Pole N. The psychophysiology of posttraumatic stress disorder: a meta-analysis. Psychol Bull. 2007;133:725-746. PMID: 17723027
44. Lanius RA, Bluhm R, Lanius U, Pain C. A review of neuroimaging studies in PTSD: heterogeneity of response to symptom provocation. J Psychiat Res. 2006;40:709-729. PMID: 16214172
45. Kolassa IT, Eckart C, Ruf M, Neuner F, De Quervain DJ, Elbert T. Lack of cortisol response in patients with posttraumatic stress disorder (PTSD) undergoing a diagnostic interview. BMC Psychiatry. 2007;7:54. PMID: 17916253
46. Roth TL, Lubin FD, Funk AJ, Sweatt JD. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry. 2009;65:760-769. doi: 10.1016/j.biopsych.2008.11.028 PMID: 19150054
47. Szyf M. The early life environment and the epigenome. Biochim Biophys Acta. 2009;1790:878-885. doi: 10.1016/j.bbagen. 2009.01.009 PMID: 19364482
48. Coid J, Petruckevitch A, Feder G, Chung WS, Richardson J, Moorey S. Relation between childhood sexual and physical abuse and risk of revictimisation in women: a cross-sectional survey. Lancet. 2001;358:450-454. PMID: 11513908
49. Dettenborn L, Muhtz C, Skoluda N, Stalder T, Steudte S, Hinkelmann K, et al. Introducing a novel method to assess cumulative steroid concentrations: Increased hair cortisol concentrations over 6 months in medicated patients with depression. Stress. 2012;15:348-353. doi: 10.3109/10253890. 2011.619239 PMID: 22043813
50. Bosch NM, Riese H, Reijneveld SA, Bakker MP, Verhulst FC, Ormel J, et al. Timing matters: Long term effects of adversities from prenatal period up to adolescence on adolescents' cortisol stress response. The TRAILS study. Psychoneuroendocrinology. 2012;37:1439-1447. doi: 10.1016/j.psyneuen. 2012. 01.013 PMID: 22365483
51. Teicher MH, Andersen SL, Polcari A, Anderson CM, Navalta CP, Kim DM. The neurobiological consequences of early stress and childhood maltreatment. Neurosci Biobehav Rev. 2003;27:33-44. PMID: 12732221
52. Andersen SL, Teicher MH. Stress, sensitive periods and maturational events in adolescent depression. Trends Neurosci. 2008;31:183-191. doi: 10.1016/j.tins.2008.01.004 PMID: 18329735
53. Koopman C, Sephton S, Abercrombie HC, Classen C, Butler LD, Gore-Felton C, et al. Dissociative symptoms and cortisol responses to recounting traumatic experiences among childhood sexual abuse survivors with PTSD. J Trauma Dissociation. 2003;4:29-46.
54. Radtke KM, Ruf M, Gunter HM, Dohrmann K, Schauer M, Meyer A, et al. Transgenerational impact of intimate partner violence on methylation in the promoter of the glucocorticoid receptor. Transl Psychiatry. 2011;1:e21. doi: 10.1038/tp. 2011.21 PMID: 22832523
55. Kirschbaum C, Pirke KM, Hellhammer DH. The 'Trier Social Stress Test'-a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology. 1993;28:76-81. PMID: 8255414