Hair cortisol concentrations and cortisol stress reactivity predict PTSD symptom increase after trauma exposure during military deployment

Psychoneuroendocrinology

Volumn 59, Issue , 2015, Pages 123-133

  Steudte Schmiedgen, Susann ^a   Stalder, Tobias ^a   Schönfeld, Sabine ^a   Wittchen, Hans Ulrich ^a   Trautmann, Sebastian ^a   Alexander, Nina ^a   Miller, Robert ^a   Kirschbaum, Clemens ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Cortisol; Hair; Posttraumatic stress disorder; Saliva; Traumatization; Trier social stress test

Indexed keywords

HYDROCORTISONE;

ADULT; AFGHANISTAN; ARTICLE; CONTROLLED STUDY; HAIR LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; INJURY; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; MILITARY DEPLOYMENT; POSTTRAUMATIC STRESS DISORDER; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SOCIAL STRESS; SOLDIER; STRESS; SYMPTOMATOLOGY; CHEMISTRY; HAIR; LIFE EVENT; MENTAL STRESS; METABOLISM; PSYCHOLOGY; PSYCHOMETRY; RISK FACTOR; SALIVA; STRESS DISORDERS, POST-TRAUMATIC; WAR;

ADULT; AFGHAN CAMPAIGN 2001-; HAIR; HUMANS; HYDROCORTISONE; LIFE CHANGE EVENTS; LONGITUDINAL STUDIES; MALE; MILITARY PERSONNEL; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; PSYCHOMETRICS; RISK FACTORS; SALIVA; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; WOUNDS AND INJURIES;

EID: 84937396669     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2015.05.007     Document Type: Article

References (50)

1. Allen A.P., Kennedy P.J., Cryan J.F., Dinan T.G., Clarke G. Biological and psychological markers of stress in humans: focus on the Trier Social Stress Test. Neurosci. Biobehav. Rev. 2014, 38:94-124.
2. Bomyea J., Risbrough V., Lang A.J. A consideration of select pre-trauma factors as key vulnerabilities in PTSD. Clin. Psychol. Rev. 2012, 32:630-641.
3. Bremner J.D., Vythilingam M., Vermetten E., Adil J., Khan S., Nazeer A., Afzal N., McGlashan T., Elzinga B., Anderson G.M., Heninger G., Southwick S.M., Charney D.S. Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology 2003, 28:733-750.
4. Breslau N. The epidemiology of trauma, PTSD, and other posttrauma disorders. Trauma Violence Abuse 2009, 10:198-210.
5. Delahanty D.L., Raimonde A.J., Spoonster E. Initial posttraumatic urinary cortisol levels predict subsequent PTSD symptoms in motor vehicle accident victims. Biol. Psychiatry 2000, 48:940-947.
6. Delahanty D.L., Raimonde A.J., Spoonster E., Cullado M. Injury severity, prior trauma history, urinary cortisol levels, and acute PTSD in motor vehicle accident victims. J. Anxiety Disord. 2003, 17:149-164.
7. Elzinga B.M., Roelofs K., Tollenaar M.S., Bakvis P., van Pelt J., Spinhoven P. Diminished cortisol responses to psychosocial stress associated with lifetime adverse events a study among healthy young subjects. Psychoneuroendocrinology 2008, 33:227-237.
8. Elzinga B.M., Schmahl C.G., Vermetten E., van Dyck R., Bremner J.D. Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD. Neuropsychopharmacology 2003, 28:1656-1665.
9. Foley P., Kirschbaum C. Human hypothalamus-pituitary-adrenal axis responses to acute psychosocial stress in laboratory settings. Neurosci. Biobehav. Rev. 2010, 35:91-96.
10. Gao W., Stalder T., Foley P., Rauh M., Deng H., Kirschbaum C. Quantitative analysis of steroid hormones in human hair using a column-switching LC-APCI-MS/MS assay. J. Chromatogr., B 2013, 928:1-8.
11. Heinrichs M., Wagner D., Schoch W., Soravia L.M., Hellhammer D.H., Ehlert U. Predicting posttraumatic stress symptoms from pretraumatic risk factors: a 2-year prospective follow-up study in firefighters. Am. J. Psychiatry 2005, 162:2276-2286.
12. Holz E., Lass-Hennemann J., Streb M., Pfaltz M., Michael T. Effects of acute cortisol administration on perceptual priming of trauma-related material. PLoS ONE 2014, 9:e104864.
13. Hruska B., Cullen P.K., Delahanty D.L. Pharmacological modulation of acute trauma memories to prevent PTSD: considerations from a developmental perspective. Neurobiol. Learn. Mem. 2014, 112:122-129.
14. Kirschbaum C., Pirke K.M., Hellhammer D.H. The 'Trier Social Stress Test'-a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 1993, 28:76-81.
15. Kolassa I.T., Elbert T. Structural and functional neuroplasticity in relation to traumatic stress. Curr. Dir. Psychol. Sci. 2007, 16:321-325.
16. Lovallo W.R., Farag N.H., Sorocco K.H., Cohoon A.J., Vincent A.S. Lifetime adversity leads to blunted stress axis reactivity: studies from the Oklahoma family health patterns project. Biol. Psychiatry 2012, 71:344-349.
17. Lukaschek K., Kruse J., Emeny R.T., Lacruz M.E., von Eisenhart Rothe A., Ladwig K.H. Lifetime traumatic experiences and their impact on PTSD: a general population study. Soc. Psychiatry Psychiatr. Epidemiol. 2013, 48:525-532.
18. Luo H., Hu X., Liu X., Ma X., Guo W., Qiu C., Wang Y., Wang Q., Zhang X., Zhang W., Hannum G., Zhang K., Liu X., Li T. Hair cortisol level as a biomarker for altered hypothalamic-pituitary-adrenal activity in female adolescents with posttraumatic stress disorder after the 2008 Wenchuan earthquake. Biol. Psychiatry 2012, 72:65-69.
19. Meewisse M.L., Reitsma J.B., de Vries G.J., Gersons B.P., Olff M. Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis. Br. J. Psychiatry 2007, 191:387-392.
20. Miller G.E., Chen E., Zhou E.S. If it goes up, must it come down? Chronic stress and the hypothalamic-pituitary-adrenocortical axis in humans. Psychol. Bull. 2007, 133:25-45.
21. Morris M.C., Compas B.E., Garber J. Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis. Clin. Psychol. Rev. 2012, 32:301-315.
22. Mouthaan J., Sijbrandij M., Luitse J.S., Goslings J.C., Gersons B.P., Olff M. The role of acute cortisol and DHEAS in predicting acute and chronic PTSD symptoms. Psychoneuroendocrinology 2014, 45:179-186.
23. Neuner F., Schauer M., Karunakara U., Klaschik C., Robert C., Elbert T. Psychological trauma and evidence for enhanced vulnerability for posttraumatic stress disorder through previous trauma among West Nile refugees. BMC Psychiatry 2004, 4:34.
24. Pruessner J.C., Kirschbaum C., Meinlschmid G., Hellhammer D.H. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 2003, 28:916-931.
25. Rohleder N., Joksimovic L., Wolf J.M., Kirschbaum C. Hypocortisolism and increased glucocorticoid sensitivity of pro-inflammatory cytokine production in Bosnian war refugees with posttraumatic stress disorder. Biol. Psychiatry 2004, 55:745-751.
26. Simeon D., Knutelska M., Yehuda R., Putnam F., Schmeidler J., Smith L.M. Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers. Biol. Psychiatry 2007, 61:966-973.
27. Smid G.E., van Zuiden M., Geuze E., Kavelaars A., Heijnen C.J., Vermetten E. Cytokine production as a putative biological mechanism underlying stress sensitization in high combat exposed soldiers. Psychoneuroendocrinology 2015, 51:534-546.
28. Stalder T., Evans P., Hucklebridge F., Clow A. Associations between psychosocial state variables and the cortisol awakening response in a single case study. Psychoneuroendocrinology 2010, 35:209-214.
29. Stalder T., Kirschbaum C. Analysis of cortisol in hair-state of the art and future directions. Brain Behav. Immun. 2012, 26:1019-1029.
30. Staufenbiel S.M., Penninx B.W., Spijker A.T., Elzinga B.M., van Rossum E.F. Hair cortisol, stress exposure, and mental health in humans: a systematic review. Psychoneuroendocrinology 2013, 38:1220-1235.
31. Steudte S., Kirschbaum C., Gao W., Alexander N., Schonfeld S., Hoyer J., Stalder T. Hair cortisol as a biomarker of traumatization in healthy individuals and posttraumatic stress disorder patients. Biol. Psychiatry 2013, 74:639-646.
32. Steudte S., Kolassa I.T., Stalder T., Pfeiffer A., Kirschbaum C., Elbert T. Increased cortisol concentrations in hair of severely traumatized Ugandan individuals with PTSD. Psychoneuroendocrinology 2011, 36:1193-1200.
33. Trautmann S., Schönfeld S., Behrendt S., Heinrich A., Höfler M., Siegel S., Zimmermann P., Wittchen H.-U. Predictors of changes in daily alcohol consumption in the aftermath of military deployment. Drug Alcohol Depend. 2015, 147:175-182.
34. Trickett P.K., Noll J.G., Susman E.J., Shenk C.E., Putnam F.W. Attenuation of cortisol across development for victims of sexual abuse. Dev. Psychopathol. 2010, 22:165-175.
35. van Zuiden M., Geuze E., Willemen H.L., Vermetten E., Maas M., Amarouchi K., Kavelaars A., Heijnen C.J. Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study. Biol. Psychiatry 2012, 71:309-316.
36. van Zuiden M., Geuze E., Willemen H.L., Vermetten E., Maas M., Heijnen C.J., Kavelaars A. Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment. Am. J. Psychiatry 2011, 168:89-96.
37. van Zuiden M., Heijnen C.J., Maas M., Amarouchi K., Vermetten E., Geuze E., Kavelaars A. Glucocorticoid sensitivity of leukocytes predicts PTSD, depressive and fatigue symptoms after military deployment: a prospective study. Psychoneuroendocrinology 2012, 37:1822-1836.
38. van Zuiden M., Kavelaars A., Rademaker A.R., Vermetten E., Heijnen C.J., Geuze E. A prospective study on personality and the cortisol awakening response to predict posttraumatic stress symptoms in response to military deployment. J. Psychiatr. Res. 2011, 45:713-719.
39. Walsh K., Nugent N.R., Kotte A., Amstadter A.B., Wang S., Guille C., Acierno R., Kilpatrick D.G., Resnick H.S. Cortisol at the emergency room rape visit as a predictor of PTSD and depression symptoms over time. Psychoneuroendocrinology 2013, 38:2520-2528.
40. Weathers F., Litz B.T., Huska J., Keane T.M. PTSD-Checklist for DSM-IV (PCL-C) 1997, National Center for PTSD, Boston, MA.
41. Wingenfeld K., Spitzer C., Mensebach C., Grabe H.J., Hill A., Gast U., Schlosser N., Hopp H., Beblo T., Driessen M. The German version of the Childhood Trauma Questionnaire (CTQ): preliminary psychometric properties. Psychother. Psychosom. Med. Psychol. 2010, 60:442-450.
42. Wittchen H.U., Pfister H. DIA-X-Interviews: Manual für Screening-Verfahrenund Interview; Interviewheft Längsschnittuntersuchung (DIA-X-Lifetime); Ergänzungsheft (DIA-X-Lifetime); Interviewheft Querschnittuntersuchung (DIA-X-12Monate); Ergänzungsheft (DIA-X-12 Monate); PC-Programm zur Durchführung des Interviews (Längs- und Querschnittuntersuchung); Auswertungsprogramm 1997, Swets and Zeitlinger, Frankfurt.
43. Wittchen H.-U., Schönfeld S. CIDI-Military Version (MI) 2009, Technische Universität Dresden, Dresden, (unpublished manual and computer-assisted personal interview).
44. Wittchen H.-U., Schönfeld S., Kirschbaum C., Thurau C., Trautmann S., Steudte S., Klotsche J., Hofler M., Hauffa R., Zimmermann P. Traumatic experiences and posttraumatic stress disorder in soldiers following deployment abroad: how big is the hidden problem?. Dtsch. Arztebl. Int. 2012, 109:559-568.
45. Wittchen H.-U., Schönfeld S., Kirschbaum C., Trautmann S., Thurau C., Siegert J., Höfler M., Hauffa R., Zimmermann P. Rates of mental disorders among German soldiers deployed to Afghanistan: increased risk of PTSD or of mental disorders in general?. J. Depress. Anxiety 2013, 2:1-7.
46. Wittchen H.-U., Schönfeld S., Thurau C., Trautmann S., Galle M., Mark K., Hauffa R., Zimmermann P., Schaefer J., Steudte S., Siegert J., Hofler M., Kirschbaum C. Prevalence, incidence and determinants of PTSD and other mental disorders: design and methods of the PID-PTSD+3 study. Int. J. Method Psychtr. 2012, 21:98-116.
47. Yehuda R. Status of glucocorticoid alterations in post-traumatic stress disorder. Ann. N.Y. Acad. Sci. 2009, 1179:56-69.
48. Yehuda R., Lowy M.T., Southwick S.M., Shaffer D., Giller E.L. Lymphocyte glucocorticoid receptor number in posttraumatic stress disorder. Am. J. Psychiatry 1991, 148:499-504.
49. Yirmiya R., Goshen I. Immune modulation of learning, memory, neural plasticity and neurogenesis. Brain. Behav. Immun. 2011, 25:181-213.
50. Zoladz P.R., Diamond D.M. Current status on behavioral and biological markers of PTSD: a search for clarity in a conflicting literature. Neurosci. Biobehav. Rev. 2013, 37:860-895.