Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients

Psychoneuroendocrinology

Volumn 55, Issue , 2015, Pages 102-115

  Zaba, Monika ^a   Kirmeier, Thomas ^a   Ionescu, Irina A ^a   Wollweber, Bastian ^a   Buell, Dominik R ^a   Gall Kleebach, Dominique J ^a   Schubert, Christine F ^a   Novak, Bozidar ^a   Huber, Christine ^a   Köhler, Katharina ^a   Holsboer, Florian ^a   Pütz, Benno ^a   Müller Myhsok, Bertram ^a   Höhne, Nina ^a   Uhr, Manfred ^a   Ising, Marcus ^a   Herrmann, Leonie ^a   Schmidt, Ulrike ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

FKBP5; Gene expression; Posttraumatic stress disorder; PTSD; PTSD subtypes; Stress reactivity; Trier Social Stress Test

Indexed keywords

FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 51; MINERALOCORTICOID RECEPTOR; UNCLASSIFIED DRUG; CORTICOTROPIN; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MESSENGER RNA; NR3C1 PROTEIN, HUMAN; NR3C2 PROTEIN, HUMAN; TACROLIMUS BINDING PROTEIN 4; TACROLIMUS BINDING PROTEIN 5; TRANSCRIPTOME;

ADULT; ARTICLE; CARDIOVASCULAR PARAMETERS; CLINICAL ARTICLE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; ENDOCRINE PARAMETERS; ENDOPHENOTYPE; FEMALE; GENE EXPRESSION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MEDICAL PARAMETERS; PATIENT ASSESSMENT; POSTTRAUMATIC STRESS DISORDER; PREVALENCE; PRIORITY JOURNAL; PSYCHOLOGIC TEST; PSYCHOLOGICAL PARAMETERS; TRIER SOCIAL STRESS TEST; YOUNG ADULT; CASE CONTROL STUDY; CHILDHOOD TRAUMA SURVIVOR; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MENTAL STRESS; METABOLISM; MIDDLE AGED; PSYCHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADRENOCORTICOTROPIC HORMONE; ADULT; ADULT SURVIVORS OF CHILD ADVERSE EVENTS; CASE-CONTROL STUDIES; COHORT STUDIES; ENDOPHENOTYPES; FEMALE; HUMANS; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MIDDLE AGED; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS DISORDERS, POST-TRAUMATIC; STRESS, PSYCHOLOGICAL; TACROLIMUS BINDING PROTEINS; TRANSCRIPTOME;

EID: 84925829118     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2015.02.005     Document Type: Article

References (58)

1. American Psychiatric Association Diagnostic and Statistical Manual of Mental Health Disorders (4th editor) 1994, Author, Washington, DC.
2. Anacker C., Zunszain P.A., Carvalho L.A., Pariante C.M. The glucocorticoid receptor: pivot of depression and of antidepressant treatment?. Psychoneuroendocrinology 2011, 36:415-425. 10.1016/j.psyneuen.2010.03.007.
3. Berger W., Mendlowicz M.V., Marques-Portella C., Kinrys G., Fontenelle L.F., Marmar C.R., Figueira I. Pharmacologic alternatives to antidepressants in posttraumatic stress disorder: a systematic review. Prog. Neuropsychopharmacol. Biol. Psychiatry 2009, 33:169-180. 10.1016/j.pnpbp.2008.12.004.
4. Bremner J.D., Vythilingam M., Vermetten E., Adil J., Khan S., Nazeer A., Afzal N., McGlashan T., Elzinga B., Anderson G.M., Heninger G., Southwick S.M., Charney D.S. Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse. Psychoneuroendocrinology 2003, 28:733-750.
5. Clohessy S., Ehlers A. PTSD symptoms, response to intrusive memories and coping in ambulance service workers. Br. J. Clin. Psychol. Br. Psychol. Soc. 1999, 38(Pt 3):251-265.
6. Dackis M.N., Rogosch F.A., Oshri A., Cicchetti D. The role of limbic system irritability in linking history of childhood maltreatment and psychiatric outcomes in low-income, high-risk women: moderation by FK506 binding protein 5 haplotype. Dev. Psychopathol. 2012, 24:1237-1252. 10.1017/S0954579412000673.
7. de Kleine R.A., Rothbaum B.O., van Minnen A. Pharmacological enhancement of exposure-based treatment in PTSD: a qualitative review. Eur. J. Psychotraumatol. 2013, 4. 10.3402/ejpt.v4i0.21626.
8. de Kloet C., Vermetten E., Lentjes E., Geuze E., van Pelt J., Manuel R., Heijnen C., Westenberg H. Differences in the response to the combined DEX-CRH test between PTSD patients with and without co-morbid depressive disorder. Psychoneuroendocrinology 2008, 33:313-320. 10.1016/j.psyneuen.2007.11.016.
9. Dunmore E., Clark D.M., Ehlers A. Cognitive factors involved in the onset and maintenance of posttraumatic stress disorder (PTSD) after physical or sexual assault. Behav. Res. Ther. 1999, 37:809-829. 10.1016/S0005-7967(98)00181-8.
10. Ehlers A. Posttraumatische Belastungsstörung 1999, Hogrefe, Göttingen.
11. Elzinga B.M., Roelofs K., Tollenaar M.S., Bakvis P., van Pelt J., Spinhoven P. Diminished cortisol responses to psychosocial stress associated with lifetime adverse events a study among healthy young subjects. Psychoneuroendocrinology 2008, 33:227-237. 10.1016/j.psyneuen.2007.11.004.
12. Elzinga B.M., Schmahl C.G., Vermetten E., van Dyck R., Bremner J.D. Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol. 2003, 28:1656-1665. 10.1038/sj.npp.1300226.
13. Erdmann G., Janke W. SVF-Stressverarbeitungsfragebogen 2008, Hogrefe, Göttingen.
14. Erhardt A., Ising M., Unschuld P.G., Kern N., Lucae S., Pütz B., Uhr M., Binder E.B., Holsboer F., Keck M.E. Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder. Neuropsychopharmacology 2006, 31:2515-2522. 10.1038/sj.npp.1301168.
15. Fani N., King T.Z., Jovanovic T., Glover E.M., Bradley B., Choi K., Ely T., Gutman D.A., Ressler K.J. White matter integrity in highly traumatized adults with and without post-traumatic stress disorder. Neuropsychopharmacology 2012, 37:2740-2746. 10.1038/npp.2012.146.
16. Frodl T., O'Keane V. How does the brain deal with cumulative stress?. A review with focus on developmental stress, HPA axis function and hippocampal structure in humans. Neurobiol. Dis. 2013, 52:24-37. 10.1016/j.nbd.2012.03.012.
17. Gola H., Engler H., Schauer M., Adenauer H., Riether C., Kolassa S., Elbert T., Kolassa I.-T. Victims of rape show increased cortisol responses to trauma reminders: a study in individuals with war- and torture-related PTSD. Psychoneuroendocrinology 2012, 37:213-220. 10.1016/j.psyneuen.2011.06.005.
18. Guest P.C., Martins-de-Souza D., Vanattou-Saifoudine N., Harris L.W., Bahn S. Abnormalities in metabolism and hypothalamic-pituitary-adrenal axis function in schizophrenia. Int. Rev. Neurobiol. 2011, 101:145-168. 10.1016/B978-0-12-387718-5.00006-7.
19. Hautzinger M., Bailer M., Worall H., Keller F. BDI Beck-Depressions-Inventar Testhandbuch 2. überarbeitete Auflage 1995, Verlag Hans Huber, Bern.
20. Hensel-Dittmann D., Schauer M., Ruf M., Catani C., Odenwald M., Elbert T., Neuner F. Treatment of traumatized victims of war and torture: a randomized controlled comparison of narrative exposure therapy and stress inoculation training. Psychother. Psychosom. 2011, 80:345-352. 10.1159/000327253.
21. Herrmann L., Ionescu I.A., Henes K., Golub Y., Wang N.X.R., Buell D.R., Holsboer F., Wotjak C.T., Schmidt U. Long-lasting hippocampal synaptic protein loss in a mouse model of posttraumatic stress disorder. PLoS ONE 2012, 7:e42603. 10.1371/journal.pone.0042603.
22. Kessler R.C., Sonnega A., Bromet E., Hughes M., Nelson C.B. Posttraumatic stress disorder in the National Comorbidity Survey. Arch. Gen. Psychiatry 1995, 52:1048-1060.
23. Kirschbaum C., Pirke K.M., Hellhammer D.H. The "Trier Social Stress Test"-a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology 1993, 28:76-81. DOI 119004.
24. Klaassens E.R., Giltay E.J., Cuijpers P., van Veen T., Zitman F.G. Adulthood trauma and HPA-axis functioning in healthy subjects and PTSD patients: a meta-analysis. Psychoneuroendocrinology 2012, 37:317-331. 10.1016/j.psyneuen.2011.07.003.
25. Klengel T., Mehta D., Anacker C., Rex-Haffner M., Pruessner J.C., Pariante C.M., Pace T.W.W., Mercer K.B., Mayberg H.S., Bradley B., Nemeroff C.B., Holsboer F., Heim C.M., Ressler K.J., Rein T., Binder E.B. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat. Neurosci. 2013, 16:33-41. 10.1038/nn.3275.
26. Koenen K.C., Saxe G., Purcell S., Smoller J.W., Bartholomew D., Miller A., Hall E., Kaplow J., Bosquet M., Moulton S., Baldwin C. Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol. Psychiatry 2005, 10:1058-1059. 10.1038/sj.mp.4001727.
27. Laux L., Glanzmann P., Schaffner P., Spielberger C.D. Das State-Trait-Angstinventar. Theoretische Grundlagen und Handanweisung 1981, Belz Test GmbH, Weinheim.
28. Levy-Gigi E., Szabó C., Kelemen O., Kéri S. Association among clinical response, hippocampal volume, and FKBP5 gene expression in individuals with posttraumatic stress disorder receiving cognitive behavioral therapy. Biol. Psychiatry 2013, 74:793-800. 10.1016/j.biopsych.2013.05.017.
29. Lipov E., Kelzenberg B. Sympathetic system modulation to treat post-traumatic stress disorder (PTSD): a review of clinical evidence and neurobiology. J. Affect. Disord. 2012, 142:1-5. 10.1016/j.jad.2012.04.011.
30. Lovallo W.R., Farag N.H., Sorocco K.H., Cohoon A.J., Vincent A.S. Lifetime adversity leads to blunted stress axis reactivity: studies from the Oklahoma Family Health Patterns Project. Biol. Psychiatry 2012, 71:344-349. 10.1016/j.biopsych.2011.10.018.
31. MacMillan H.L., Georgiades K., Duku E.K., Shea A., Steiner M., Niec A., Tanaka M., Gensey S., Spree S., Vella E., Walsh C.A., De Bellis M.D., Van der Meulen J., Boyle M.H., Schmidt L.A. Cortisol response to stress in female youths exposed to childhood maltreatment: results of the youth mood project. Biol. Psychiatry 2009, 66:62-68. 10.1016/j.biopsych.2008.12.014.
32. Matić G., Vojnović Milutinović D., Nestorov J., Elaković I., Manitašević Jovanović S., Elzaedi Y.M., Perišić T., Dund{stroke}erski J., Damjanović S., Knežević G., Špirić Ž., Vermetten E., Savić D. Mineralocorticoid receptor and heat shock protein expression levels in peripheral lymphocytes from war trauma-exposed men with and without PTSD. Psychiatry Res. 2014, 215:379-385. 10.1016/j.psychres.2013.11.022.
33. Miller R., Plessow F., Kirschbaum C., Stalder T. Classification criteria for distinguishing cortisol responders from nonresponders to psychosocial stress: evaluation of salivary cortisol pulse detection in panel designs. Psychosom. Med. 2013, 75:832-840. 10.1097/PSY.0000000000000002.
34. Morris M.C., Compas B.E., Garber J. Relations among posttraumatic stress disorder, comorbid major depression, and HPA function: a systematic review and meta-analysis. Clin. Psychol. Rev. 2012, 32:301-315. 10.1016/j.cpr.2012.02.002.
35. Ostrowski S.A., Delahanty D.L. Prospects for the pharmacological prevention of post-traumatic stress in vulnerable individuals. CNS Drugs 2014, 28:195-203. 10.1007/s40263-014-0145-7.
36. Pérez-Edgar K., Bar-Haim Y., McDermott J.M., Gorodetsky E., Hodgkinson C.A., Goldman D., Ernst M., Pine D.S., Fox N.A. Variations in the serotonin-transporter gene are associated with attention bias patterns to positive and negative emotion faces. Biol. Psychol. 2010, 83:269-271. 10.1016/j.biopsycho.2009.08.009.
37. Pierrehumbert B., Torrisi R., Glatz N., Dimitrova N., Heinrichs M., Halfon O. The influence of attachment on perceived stress and cortisol response to acute stress in women sexually abused in childhood or adolescence. Psychoneuroendocrinology 2009, 34:924-938. 10.1016/j.psyneuen.2009.01.006.
38. Pitman R.K., Rasmusson A.M., Koenen K.C., Shin L.M., Orr S.P., Gilbertson M.W., Milad M.R., Liberzon I. Biological studies of post-traumatic stress disorder. Nat. Rev. Neurosci. 2012, 13:769-787. 10.1038/nrn3339.
39. Roelofs K., van Peer J., Berretty E., Jong P.de., Spinhoven P., Elzinga B.M. Hypothalamus-pituitary-adrenal axis hyperresponsiveness is associated with increased social avoidance behavior in social phobia. Biol. Psychiatry 2009, 65:336-343. 10.1016/j.biopsych.2008.08.022.
40. Schmahl C., Berne K., Krause A., Kleindienst N., Valerius G., Vermetten E., Bohus M. Hippocampus and amygdala volumes in patients with borderline personality disorder with or without posttraumatic stress disorder. J. Psychiatry Neurosci. JPN 2009, 34:289-295.
41. Schmidt U., Buell D.R., Ionescu I.A., Gassen N.C., Holsboer F., Cox M.B., Novak B., Huber C., Hartmann J., Schmidt M.V., Touma C., Rein T., Herrmann L. A role for synapsin in FKBP51 modulation of stress responsiveness: convergent evidence from animal and human studies. Psychoneuroendocrinology 2014, 52C:43-58. 10.1016/j.psyneuen.2014.11.005.
42. Schmidt U., Gall-Kleebach D. Psychotraumatherapy of soldiers and veterans-a report of experiences. Psychotherapie 2010, 15:317-321. [Article in German].
43. Schmidt U., Herrmann L., Hagl K., Novak B., Huber C., Holsboer F., Wotjak C.T., Buell D.R. Therapeutic action of fluoxetine is associated with a reduction in prefrontal cortical miR-1971 expression levels in a mouse model of posttraumatic stress disorder. Front. Psychiatry 2013, 4:66. 10.3389/fpsyt.2013.00066.
44. Schmidt U., Kaltwasser S.F., Wotjak C.T. Biomarkers in posttraumatic stress disorder: overview and implications for future research. Dis. Markers 2013, 35:43-54. 10.1155/2013/835876.
45. Schmidt U., Willmund G.-D., Holsboer F., Wotjak C.T., Gallinat J., Kowalski J.T., Zimmermann P. Searching for non-genetic molecular and imaging PTSD risk and resilience markers: systematic review of literature and design of the German Armed Forces PTSD biomarker study. Psychoneuroendocrinology 2014, 10.1016/j.psyneuen.2014.08.020.
46. Schnyder U., Moergeli H. German version of Clinician-Administered PTSD scale. J. Trauma Stress 2002, 15:487-492. 10.1023/A:1020922023090.
47. Schroeder A., Mueller O., Stocker S., Salowsky R., Leiber M., Gassmann M., Lightfoot S., Menzel W., Granzow M., Ragg T. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol. Biol. 2006, 7:3. 10.1186/1471-2199-7-3.
48. Simeon D., Knutelska M., Yehuda R., Putnam F., Schmeidler J., Smith L.M. Hypothalamic-pituitary-adrenal axis function in dissociative disorders, post-traumatic stress disorder, and healthy volunteers. Biol. Psychiatry 2007, 61:966-973. 10.1016/j.biopsych.2006.07.030.
49. Smyth J., Ockenfels M.C., Porter L., Kirschbaum C., Hellhammer D.H., Stone A.A. Stressors and mood measured on a momentary basis are associated with salivary cortisol secretion. Psychoneuroendocrinology 1998, 23:353-370.
50. Spitzer C., Stieglitz R.-F., Freyberger H.J. FDS. Fragebogen zu Dissoziativen Symptomen 2005, Verlag Hans Huber, Bern.
51. Stiglmayr C.E., Braakmann D., Haaf B., Stieglitz R.-F., Bohus M. Entwicklung und psychometrische Charakteristika der Dissoziations-Spannungs-Skala akut (DSS-akut). PPmP-Psychother. Psychosom. Med. Psychol. 2003, 53:287-294. 10.1055/s-2003-40495.
52. Stoppelbein L., Greening L., Fite P. The role of cortisol in PTSD among women exposed to a trauma-related stressor. J. Anxiety Disord. 2012, 26:352-358. 10.1016/j.janxdis.2011.12.004.
53. Touma C., Gassen N.C., Herrmann L., Cheung-Flynn J., Büll D.R., Ionescu I.A., Heinzmann J.-M., Knapman A., Siebertz A., Depping A.-M., Hartmann J., Hausch F., Schmidt M.V., Holsboer F., Ising M., Cox M.B., Schmidt U., Rein T. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biol. Psychiatry 2011, 70:928-936. 10.1016/j.biopsych.2011.07.023.
54. Trickett P.K., Gordis E., Peckins M.K., Susman E.J. Stress reactivity in maltreated and comparison male and female young adolescents. Child Maltreat. 2014, 19:27-37. 10.1177/1077559513520466.
55. von Zerssen D. Die Befindlichkeits-Skala 1976, Belz Test GmbH, Weinheim.
56. Wittchen H.-U., Pfister H. DIA-X Interviews: Manual für Screening-Verfahren und Interview; Interviewheft Längstschnittuntersuchung (DIA-X-Lifetime); Ergänzungsheft (DIA-X-Lifetime); Interview Querschnittuntersuchung (DIA-X-12 Monate); Ergänzungsheft (DIA-X-12 Monate); PC-Programm zur Durchführung des Interviews (Längs- und Querschnittuntersuchung); Auswertungsprogramm 1997, Swets & Zeitlinger, Frankfurt.
57. Wochnik G.M., Rüegg J., Abel G.A., Schmidt U., Holsboer F., Rein T. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J. Biol. Chem. 2005, 280:4609-4616. 10.1074/jbc.M407498200.
58. Yehuda R., Bierer L.M., Sarapas C., Makotkine I., Andrew R., Seckl J.R. Cortisol metabolic predictors of response to psychotherapy for symptoms of PTSD in survivors of the World Trade Center attacks on September 11, 2001. Psychoneuroendocrinology 2009, 34:1304-1313. 10.1016/j.psyneuen.2009.03.018.