The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments

Chemical Biology and Drug Design

Volumn 86, Issue 2, 2015, Pages 190-199

  Churchill, Cassandra D M ^a   Klobukowski, Mariusz ^a   Tuszynski, Jack A ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

drug discovery; molecular modeling; natural product; receptor and ligands

Indexed keywords

ALPHA TUBULIN; BETA TUBULIN; LAULIMALIDE; ANTINEOPLASTIC AGENT; MACROLIDE; TUBULIN; TUBULIN MODULATOR;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG PROTEIN BINDING; ENTROPY; HYDROGEN BOND; MICROTUBULE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; METABOLISM; PROCEDURES; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

ANTINEOPLASTIC AGENTS; BINDING SITES; DRUG DISCOVERY; MACROLIDES; MICROTUBULES; MOLECULAR DYNAMICS SIMULATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TUBULIN; TUBULIN MODULATORS;

EID: 84943245401     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12475     Document Type: Article

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