Protein kinase A-dependent phosphorylation of Dock180 at serine residue 1250 is important for glioma growth and invasion stimulated by platelet derived-growth factor receptor α

Neuro-Oncology

Volumn 17, Issue 6, 2015, Pages 832-842

  Feng, Haizhong ^a,b   Li, Yanxin ^a   Yin, Yuhua ^c   Zhang, Weiwei ^a   Hou, Yanli ^a   Zhang, Lei ^a   Li, Zuoqing ^a   Xie, Baoshu ^c   Gao, Wei Qiang ^a   Sarkaria, Jann N ^d   Raizer, Jeffery J ^b   James, C David ^b   Parsa, Andrew T ^b   Hu, Bo ^b   Cheng, Shi Yuan ^a,b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b NORTHWESTERN UNIVERSITY   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d MAYO CLINIC   (United States)

Author keywords

Dock180; Glioblastomas; PDGFR ; Phosphorylation; PKA

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; DEDICATOR OF CYTOKINESIS 1 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; KT 5720; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN KINASE B; RAC1 PROTEIN; SERINE; UNCLASSIFIED DRUG; CARBAZOLE DERIVATIVE; DOCK1 PROTEIN, HUMAN; ISOQUINOLINE DERIVATIVE; N-(2-(4-BROMOCINNAMYLAMINO)ETHYL)-5-ISOQUINOLINESULFONAMIDE; PLATELET DERIVED GROWTH FACTOR; PLATELET-DERIVED GROWTH FACTOR A; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE; RAC PROTEIN; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; CANCER GROWTH; CARCINOGENESIS; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; GENE EXPRESSION; GLIOBLASTOMA; GLIOBLASTOMA CELL LINE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TUMOR ENGRAFTMENT; TUMOR INVASION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN TUMOR; CELL MOTION; CELL SURVIVAL; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE;

ANIMALS; BRAIN NEOPLASMS; CARBAZOLES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CYCLIC AMP-DEPENDENT PROTEIN KINASES; FEMALE; GLIOBLASTOMA; HEK293 CELLS; HUMANS; ISOQUINOLINES; MICE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE INHIBITORS; PYRROLES; RAC GTP-BINDING PROTEINS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA; SIGNAL TRANSDUCTION; SULFONAMIDES;

EID: 84943181994     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/nou323     Document Type: Article

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