High throughput screening methods for assessing antibiofilm and immunomodulatory activities of synthetic peptides

Peptides

Volumn 71, Issue , 2015, Pages 276-285

  Haney, Evan F ^a   Mansour, Sarah C ^a   Hilchie, Ashley L ^a   De La Fuente Núñez, César ^a   Hancock, Robert E W ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Antibiofilm peptide; Bacterial biofilms; Immunomodulatory peptide; Peptide optimization

Indexed keywords

CELLULOSE; IDR 1002; IDR 2009; IDR 2010; IDR 2011; IDR 2012; IDR 2013; IDR HH2; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; CCL2 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; IMMUNOLOGIC FACTOR; MONOCYTE CHEMOTACTIC PROTEIN 1;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBACTERIAL ACTIVITY; ARTICLE; BIOFILM; CELL MEMBRANE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOMODULATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PSEUDOMONAS AERUGINOSA; CHEMISTRY; DRUG EFFECTS; IMMUNOLOGY; MONONUCLEAR CELL; PHYSIOLOGY; PRECLINICAL STUDY; SYNTHESIS;

ANTIMICROBIAL CATIONIC PEPTIDES; BIOFILMS; CHEMOKINE CCL2; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-1BETA; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PSEUDOMONAS AERUGINOSA;

EID: 84942991136     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2015.03.015     Document Type: Article

References (49)

1. P. Zanger, J. Holzer, R. Schleucher, H. Steffen, B. Schittek, and S. Gabrysch Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin J Infect Dis 200 2009 1907 1915 10.1086/648408
2. M. Otto Staphylococcus colonization of the skin and antimicrobial peptides Expert Rev Dermatol 5 2010 183 195 10.1586/edm.10.6
3. R. Dantes, Y. Mu, R. Belflower, D. Aragon, G. Dumyati, L.H. Harrison, and et al. National burden of invasive methicillin-resistant Staphylococcus aureus infections, United States, 2011 JAMA Intern Med 173 2013 1970 1978 10.1001/jamainternmed.2013.10423
4. G.A. Filice, J.A. Nyman, C. Lexau, C.H. Lees, L.A. Bockstedt, K. Como-Sabetti, and et al. Excess costs and utilization associated with methicillin resistance for patients with Staphylococcus aureus infection Infect Control Hosp Epidemiol 31 2010 365 373 10.1086/651094
5. L.M. Weigel, D.B. Clewell, S.R. Gill, N.C. Clark, L.K. McDougal, S.E. Flannagan, and et al. Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus Science 302 2003 1569 1571 10.1126/science.1090956
6. F. Rossi, L. Diaz, A. Wollam, D. Panesso, Y. Zhou, S. Rincon, and et al. Transferable vancomycin resistance in a community-associated MRSA lineage N Engl J Med 370 2014 1524 1531 10.1056/NEJMoa1303359
7. S.C. Mansour, O.M. Pena, and R.E.W. Hancock Host defense peptides: front-line immunomodulators Trends Immunol 35 2014 443 450 10.1016/j.it.2014.07.004
8. L.T. Nguyen, E.F. Haney, and H.J. Vogel The expanding scope of antimicrobial peptide structures and their modes of action Trends Biotechnol 29 2011 464 472 10.1016/j.tibtech.2011.05.001
9. R.E.W. Hancock, and G. Diamond The role of cationic antimicrobial peptides in innate host defences Trends Microbiol 8 2000 402 410
10. R.E.W. Hancock, and H.G. Sahl Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies Nat Biotechnol 24 2006 1551 1557
11. R. Ommori, N. Ouji, F. Mizuno, E. Kita, Y. Ikada, and H. Asada Selective induction of antimicrobial peptides from keratinocytes by staphylococcal bacteria Microb Pathog 56 2013 35 39 10.1016/j.micpath.2012.11.005
12. V. Sass, T. Schneider, M. Wilmes, C. Körner, A. Tossi, N. Novikova, and et al. Human beta-defensin 3 inhibits cell wall biosynthesis in Staphylococci Infect Immun 78 2010 2793 2800 10.1128/IAI.00688-09
13. P.Y. Ong, T. Ohtake, C. Brandt, I. Strickland, M. Boguniewicz, T. Ganz, and et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis N Engl J Med 347 2002 1151 1160 10.1056/NEJMoa021481
14. P. Zanger, D. Nurjadi, B. Vath, and P.G. Kremsner Persistent nasal carriage of Staphylococcus aureus is associated with deficient induction of human β-defensin 3 after sterile wounding of healthy skin in vivo Infect Immun 79 2011 2658 2662 10.1128/IAI.00101-11
15. E.F. Haney, and R.B.E.W. Hancock Peptide design for antimicrobial and immunomodulatory applications Biopolymers 100 2013 572 583 10.1002/bip.22250
16. E.M. Haisma, A. de Breij, H. Chan, J.T. van Dissel, J.W. Drijfhout, P.S. Hiemstra, and et al. LL-37-derived peptides eradicate multidrug-resistant Staphylococcus aureus from thermally wounded human skin equivalents Antimicrob Agents Chemother 58 2014 4411 4419 10.1128/AAC.02554-14
17. C. Björn, J. Håkansson, E. Myhrman, V. Sjöstrand, T. Haug, K. Lindgren, and et al. Anti-infectious and anti-inflammatory effects of peptide fragments sequentially derived from the antimicrobial peptide centrocin 1 isolated from the green sea urchin, Strongylocentrotus droebachiensis AMB Express 2 2012 67 10.1186/2191-0855-2-67
18. D. Lopez, H. Vlamakis, and R. Kolter Biofilms Cold Spring Harb Perspect Biol 2 2010 a000398
19. S.C. Davis, C. Ricotti, A. Cazzaniga, E. Welsh, W.H. Eaglstein, and P.M. Mertz Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo Wound Repair Regen 16 2008 23 29 10.1111/j.1524-475X.2007.00303.x
20. S.L. Percival, K.E. Hill, D.W. Williams, S.J. Hooper, D.W. Thomas, and J.W. Costerton A review of the scientific evidence for biofilms in wounds Wound Repair Regen 20 2012 647 657 10.1111/j.1524-475X.2012.00836.x
21. C. De la Fuente-Núñez, F. Reffuveille, L. Fernández, and R.E. Hancock Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies Curr Opin Microbiol 16 2013 580 589 10.1016/j.mib.2013.06.013
22. J.W. Costerton, P.S. Stewart, and E.P. Greenberg Bacterial biofilms: a common cause of persistent infections Science 284 1999 1318 1322
23. J. Overhage, A. Campisano, M. Bains, E.C. Torfs, B.H. Rehm, and R.E.W. Hancock Human host defense peptide LL-37 prevents bacterial biofilm formation Infect Immun 76 2008 4176 4182
24. C. De la Fuente-Nunez, V. Korolik, M. Bains, U. Nguyen, E.B. Breidenstein, S. Horsman, and et al. Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide Antimicrob Agents Chemother 56 2012 2696 2704
25. C. De la Fuente-Núñez, F. Reffuveille, E.F. Haney, S.K. Straus, and R.E.W. Hancock Broad-spectrum anti-biofilm peptide that targets a cellular stress response PLoS Pathog 10 2014 e1004152 10.1371/journal.ppat.1004152
26. D.M. Bowdish, D.J. Davidson, Y.E. Lau, K. Lee, M.G. Scott, and R.E.W. Hancock Impact of LL-37 on anti-infective immunity J Leukoc Biol 77 2005 451 459
27. A.L. Hilchie, K. Wuerth, and R.E.W. Hancock Immune modulation by multifaceted cationic host defense (antimicrobial) peptides Nat Chem Biol 9 2013 761 768 10.1038/nchembio.1393
28. M. Wieczorek, H. Jenssen, J. Kindrachuk, W.R. Scott, M. Elliott, K. Hilpert, and et al. Structural studies of a peptide with immune modulating and direct antimicrobial activity Chem Biol 17 2010 970 980
29. L. Steinstraesser, T. Hirsch, M. Schulte, M. Kueckelhaus, F. Jacobsen, E.A. Mersch, and et al. Innate defense regulator peptide 1018 in wound healing and wound infection PLOS ONE 7 2012 e39373
30. A. Nijnik, L. Madera, S. Ma, M. Waldbrook, M.R. Elliott, D.M. Easton, and et al. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment J Immunol 184 2010 2539 2550
31. E. Turner-Brannen, K.Y. Choi, D.N. Lippert, J.P. Cortens, R.E.W. Hancock, H. El-Gabalawy, and et al. Modulation of interleukin-1beta-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts Arthritis Res Ther 13 2011 R129
32. L. Madera, and R.E.W. Hancock Synthetic immunomodulatory peptide IDR-1002 enhances monocyte migration and adhesion on fibronectin J Innate Immun 4 2012 553 568
33. B. Rivas-Santiago, J.E. Castañeda-Delgado, C.E. Rivas Santiago, M. Waldbrook, I. González-Curiel, J.C. León-Contreras, and et al. Ability of innate defence regulator peptides IDR-1002, IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal models PLOS ONE 8 2013 e59119 10.1371/journal.pone.0059119
34. T.H.T. Brown, J. David, E. Acosta-Ramirez, J.M. Moore, S. Lee, G. Zhong, and et al. Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection Vaccine 30 2012 350 360 10.1016/j.vaccine.2011.10.086
35. J. Kindrachuk, H. Jenssen, M. Elliott, R. Townsend, A. Nijnik, S.F. Lee, and et al. A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity Vaccine 27 2009 4662 4671
36. R. Frank The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports - principles and applications J Immunol Methods 267 2002 13 26
37. K. Hilpert, D.F. Winkler, and R.E.W. Hancock Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion Nat Protoc 2 2007 1333 1349
38. D.F. Winkler, K. Hilpert, O. Brandt, and R.E.W. Hancock Synthesis of peptide arrays using SPOT-technology and the CelluSpots-method Methods Mol Biol 570 2009 157 174
39. B. Pitts, M.A. Hamilton, N. Zelver, and P.S. Stewart A microtiter-plate screening method for biofilm disinfection and removal J Microbiol Methods 54 2003 269 276
40. R.D. Jahnsen, E.F. Haney, H. Franzyk, and R.E.W. Hancock Characterization of a proteolytically stable multifunctional host defense peptidomimetic Chem Biol 20 2013 1286 1295 10.1016/j.chembiol.2013.09.007
41. B.A. Wallace, and R.W. Janes An introduction to circular dichroism and synchrotron radiation circular dichroism spectroscopy P.I. Haris, Mod. Tech. Circ. Dichroism Synchrotron Radiat. Circ. Dichroism Spectrosc 2009 IOS Press Amsterdam 1 18
42. S.L. Gellatly, and R.E.W. Hancock Pseudomonas aeruginosa: new insights into pathogenesis and host defenses Pathog Dis 67 2013 159 173 10.1111/2049-632X.12033
43. K. Gjødsbøl, J.J. Christensen, T. Karlsmark, B. Jørgensen, B.M. Klein, and K.A. Krogfelt Multiple bacterial species reside in chronic wounds: a longitudinal study Int Wound J 3 2006 225 231 10.1111/j.1742-481X.2006.00159.x
44. K. Kirketerp-Møller, P. Jensen, M. Fazli, K.G. Madsen, J. Pedersen, C. Moser, and et al. Distribution, organization, and ecology of bacteria in chronic wounds J Clin Microbiol 46 2008 2717 2722 10.1128/JCM.00501-08
45. K. Hilpert, R. Volkmer-Engert, T. Walter, and R.E.W. Hancock High-throughput generation of small antibacterial peptides with improved activity Nat Biotechnol 23 2005 1008 1012
46. A. Cherkasov, K. Hilpert, H. Jenssen, C.D. Fjell, M. Waldbrook, S.C. Mullaly, and et al. Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs ACS Chem Biol 4 2009 65 74
47. D.W. Hoskin, and A. Ramamoorthy Studies on anticancer activities of antimicrobial peptides Biochim Biophys Acta 1778 2008 357 375 10.1016/j.bbamem.2007.11.008
48. P.G. Barlow, E.G. Findlay, S.M. Currie, and D.J. Davidson Antiviral potential of cathelicidins Future Microbiol 9 2014 55 73 10.2217/fmb.13.135
49. N.-Q. Shi, X.-R. Qi, B. Xiang, and Y. Zhang A survey on "Trojan Horse" peptides: opportunities, issues and controlled entry to "Troy" J Control Release 194C 2014 53 70 10.1016/j.jconrel.2014.08.014